MicroRNA cargo of extracellular vesicles as mediators of immune dysregulation in pediatric immune thrombocytopenia: from pathogenetic drivers to biomarkers.
- 1Department of Woman, Child and General and Specialist Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy.
- 2Department of Life Sciences, Health and Health Professions, Link Campus University, Rome, Italy.
Abstract
Pediatric immune thrombocytopenia (ITP) is an acquired autoimmune disorder, caused by the production of autoantibodies against platelets which leads to thrombocytopenia. It is characterized by profound alterations in both inflammatory and immune profiles. In this context, the role of microRNAs (miRNAs) as post-transcriptional regulators of immunity and the function of extracellular vesicles (EVs) as key mediators of intercellular communication are two fundamental aspects for understanding ITP pathophysiology. In ITP, altered miRNA expression disrupts immune tolerance, lymphocyte subtype differentiation and platelet production. miRNAs are incorporated into EVs and transferred to recipient cells, which confers greater stability to the miRNAs. To date, the interaction between miRNAs and EVs in pediatric ITP has been relatively understudied. In this review, we examine the landscape of dysregulated miRNAs in ITP, focusing in particular on their role in immune dysregulation and on the contribution of EVs as carriers of pathogenic miRNAs. The relationship between EVs and miRNAs could facilitate the development of non-invasive diagnostic tools and EV-based therapeutic strategies designed to reestablish immune homeostasis in pediatric ITP.
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BibTeX
@article{argenziano2026microrna,
title = {{MicroRNA cargo of extracellular vesicles as mediators of immune dysregulation in pediatric immune thrombocytopenia: from pathogenetic drivers to biomarkers.}},
author = {Lucia Argenziano and Maria Maddalena Marrapodi and Giuseppe Di Feo and Oriana Di Domenico and Francesca Rossi and Alessandra Di Paola},
journal = {Frontiers in genetics},
year = {2026},
month = oct,
doi = {10.3389/fgene.2026.1951187},
url = {https://europepmc.org/article/MED/42928941},
note = {CC BY},
}
RIS
TY - JOUR
TI - MicroRNA cargo of extracellular vesicles as mediators of immune dysregulation in pediatric immune thrombocytopenia: from pathogenetic drivers to biomarkers.
AU - Lucia Argenziano
AU - Maria Maddalena Marrapodi
AU - Giuseppe Di Feo
AU - Oriana Di Domenico
AU - Francesca Rossi
AU - Alessandra Di Paola
PY - 2026
DA - 2026/10/12
JO - Frontiers in genetics
DO - 10.3389/fgene.2026.1951187
UR - https://europepmc.org/article/MED/42928941
AB - Pediatric immune thrombocytopenia (ITP) is an acquired autoimmune disorder, caused by the production of autoantibodies against platelets which leads to thrombocytopenia. It is characterized by profound alterations in both inflammatory and immune profiles. In this context, the role of microRNAs (miRNAs) as post-transcriptional regulators of immunity and the function of extracellular vesicles (EVs) as key mediators of intercellular communication are two fundamental aspects for understanding ITP pathophysiology. In ITP, altered miRNA expression disrupts immune tolerance, lymphocyte subtype differentiation and platelet production. miRNAs are incorporated into EVs and transferred to recipient cells, which confers greater stability to the miRNAs. To date, the interaction between miRNAs and EVs in pediatric ITP has been relatively understudied. In this review, we examine the landscape of dysregulated miRNAs in ITP, focusing in particular on their role in immune dysregulation and on the contribution of EVs as carriers of pathogenic miRNAs. The relationship between EVs and miRNAs could facilitate the development of non-invasive diagnostic tools and EV-based therapeutic strategies designed to reestablish immune homeostasis in pediatric ITP.
SN - 1664-8021
ER -