Salivary extracellular vesicles in precision periodontology: diagnostic biomarkers and therapeutic opportunities.
- 1Department of Periodontology, AB Shetty Memorial Institute of Dental Sciences (ABSMIDS), Nitte (Deemed to be University), Mangalore, India.
Abstract
Periodontitis is a chronic inflammatory disease in which clinical and radiographic assessments reflect the consequences of tissue destruction rather than ongoing biological activity. Salivary Extracellular Vesicles (EVs) have emerged as a promising source of minimally invasive biomarkers capable of reflecting real-time periodontal biology, owing to their stable, membrane-protected cargo of proteins, lipids, and regulatory nucleic acids. Current studies suggest that EVs-associated microRNAs and proteins may help distinguish periodontal health from disease and may reflect biological changes following periodontal therapy. This mini review discusses the biological origin and cargo of salivary EVs and examines their emerging relevance to precision periodontology. EVs derived from mesenchymal and periodontal ligament stem cells also show immunomodulatory, osteogenic, and regenerative effects in experimental models. Although diagnostic and therapeutic evidence is still emerging, growing findings support the potential of EVs-based approaches in periodontology. Further progress through standardised EVs isolation and characterisation, robust biomarker validation, and well-designed clinical studies will facilitate their translation into personalised periodontal care.
Related
- The Role of Neutrophil Extracellular Traps (NETosis) in Systemic Lupus Erythematosus: Molecular Mechanisms, Pathogenic Roles, Diagnostic Biomarkers, and Emerging Therapeutic Strategies
- Extracellular vesicles in the immune regulation of hematological malignancies: mechanisms, prognostic significance, and therapeutic opportunities
- Microbiota-Associated Metabolites as Biomarkers and Therapeutic Opportunities in Inflammatory Bowel Disease
- Extracellular Mitochondrial Components as Emerging Biomarkers and Therapeutic Targets in Human Diseases.
- Research progress of extracellular vesicles in PMOS: molecular mechanisms, diagnostic value, and therapeutic strategies
BibTeX
@article{vineela2026salivary,
title = {{Salivary extracellular vesicles in precision periodontology: diagnostic biomarkers and therapeutic opportunities.}},
author = {Amanchi Vineela and Amita Rao and Srilakshmi Mahadevan},
journal = {Frontiers in dental medicine},
year = {2026},
month = oct,
doi = {10.3389/fdmed.2026.1964471},
url = {https://europepmc.org/article/MED/42948552},
note = {CC BY},
}
RIS
TY - JOUR
TI - Salivary extracellular vesicles in precision periodontology: diagnostic biomarkers and therapeutic opportunities.
AU - Amanchi Vineela
AU - Amita Rao
AU - Srilakshmi Mahadevan
PY - 2026
DA - 2026/10/13
JO - Frontiers in dental medicine
DO - 10.3389/fdmed.2026.1964471
UR - https://europepmc.org/article/MED/42948552
AB - Periodontitis is a chronic inflammatory disease in which clinical and radiographic assessments reflect the consequences of tissue destruction rather than ongoing biological activity. Salivary Extracellular Vesicles (EVs) have emerged as a promising source of minimally invasive biomarkers capable of reflecting real-time periodontal biology, owing to their stable, membrane-protected cargo of proteins, lipids, and regulatory nucleic acids. Current studies suggest that EVs-associated microRNAs and proteins may help distinguish periodontal health from disease and may reflect biological changes following periodontal therapy. This mini review discusses the biological origin and cargo of salivary EVs and examines their emerging relevance to precision periodontology. EVs derived from mesenchymal and periodontal ligament stem cells also show immunomodulatory, osteogenic, and regenerative effects in experimental models. Although diagnostic and therapeutic evidence is still emerging, growing findings support the potential of EVs-based approaches in periodontology. Further progress through standardised EVs isolation and characterisation, robust biomarker validation, and well-designed clinical studies will facilitate their translation into personalised periodontal care.
SN - 2673-4915
ER -