Personalized Nutrition for Immune Optimization: A Nutrigenetic Approach to the Peripheral Blood Mononuclear Cell Response
5 affiliations
- 1Laboratory of Pesticide and Environmental Toxicology, Department of Plant Pests and Diseases, Faculty of Agriculture, Universitas Padjadjaran, Jatinangor, West Java, Indonesia
- 2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, Indonesia
- 3Prodia Clinical Laboratory, Jakarta, Indonesia
- 4Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, Indonesia
- 5Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, Malaysia
Abstract
Akash Kishor Rokade,1 Anna Meiliana,2,3 Vesara Ardhe Gatera,4 Edmund Ui-Hang Sim51Laboratory of Pesticide and Environmental Toxicology, Department of Plant Pests and Diseases, Faculty of Agriculture, Universitas Padjadjaran, Jatinangor, West Java, Indonesia; 2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, Indonesia; 3Prodia Clinical Laboratory, Jakarta, Indonesia; 4Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, Indonesia; 5Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, MalaysiaCorrespondence: Anna Meiliana, Email [email protected]: Personalized nutrition, guided by nutrigenetic insights, is a promising strategy for optimizing immune function through targeted dietary interventions. Peripheral blood mononuclear cells (PBMCs), comprising lymphocytes and monocytes, serve as a dynamic model for investigating gene–diet interactions because of their sensitivity to nutritional and genetic influences. This review aimed to synthesize current reports on the interplay between genetic variation, dietary components, and PBMC molecular responses and evaluate the clinical applicability of the interaction in the development of individualized nutritional strategies for immune optimization. A structured and narrative-focused method was used to synthesize the literature, showing the relationship between molecular knowledge and practical solutions in personalized nutrition as well as immune system optimization, with a focus on PBMCs. A thorough search was performed on PubMed, Scopus, and Google Scholar, encompassing the years 2006 to 2025. Genetic polymorphisms in the vitamin D receptor (VDR), peroxisome proliferator-activated receptor (PPAR), superoxide dismutase 2 (SOD2), and Toll-like receptor 4 (TLR4) modulated the response of PBMCs to nutrients, including vitamin D, omega-3 fatty acids, antioxidants, and polyphenols. The discussion encompassed molecular pathways involving cytokine modulation, oxidative stress, and epigenetic alterations, highlighting PBMCs as indicators of immunological resistance and chronic disease susceptibility. The exploration of multiomics integration to achieve precision nutrition holds significant implications for clinical practice and public health. By using PBMC-based nutrigenetic profiling as a monitoring and stratification tool, future interventions may move toward more focused immune optimization and improved health outcomes, pending further validation in longitudinal and interventional studies.Keywords: nutrigenomics, genetic polymorphism, personalized nutrition, functional foods
Related
- Single-cell RNA sequencing delineates compositional and transcriptional changes of porcine peripheral blood mononuclear cell populations following Salmonella I 4,[5],12:i:- inoculation
- Novel human long noncoding RNA responses to Candida auris and its cell-wall components in peripheral blood mononuclear cells
- Peripheral blood mononuclear cells as a novel source for mitochondrial transplantation therapy in peripheral nerve injury repair
- Effect of bacteriophages on cytokine production by human peripheral blood mononuclear cells and their subpopulations
- Single-cell transcriptome sequencing analysis of peripheral blood mononuclear cells reveals immune signatures in patients with polymyalgia rheumatica
BibTeX
@article{rokade2026personalized,
title = {{Personalized Nutrition for Immune Optimization: A Nutrigenetic Approach to the Peripheral Blood Mononuclear Cell Response}},
author = {Akash Kishor Rokade and Anna Meiliana and Vesara Ardhe Gatera and Edmund Ui-Hang Sim},
journal = {Pharmacogenomics and Personalized Medicine},
year = {2026},
month = oct,
doi = {10.2147/pgpm.s636883},
url = {https://www.dovepress.com/personalized-nutrition-for-immune-optimization-a-nutrigenetic-approach-peer-reviewed-fulltext-article-PGPM},
note = {CC BY-NC 4.0},
}
RIS
TY - JOUR
TI - Personalized Nutrition for Immune Optimization: A Nutrigenetic Approach to the Peripheral Blood Mononuclear Cell Response
AU - Akash Kishor Rokade
AU - Anna Meiliana
AU - Vesara Ardhe Gatera
AU - Edmund Ui-Hang Sim
PY - 2026
DA - 2026/10/27
JO - Pharmacogenomics and Personalized Medicine
DO - 10.2147/pgpm.s636883
UR - https://www.dovepress.com/personalized-nutrition-for-immune-optimization-a-nutrigenetic-approach-peer-reviewed-fulltext-article-PGPM
AB - Akash Kishor Rokade,1 Anna Meiliana,2,3 Vesara Ardhe Gatera,4 Edmund Ui-Hang Sim51Laboratory of Pesticide and Environmental Toxicology, Department of Plant Pests and Diseases, Faculty of Agriculture, Universitas Padjadjaran, Jatinangor, West Java, Indonesia; 2Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, Indonesia; 3Prodia Clinical Laboratory, Jakarta, Indonesia; 4Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Jatinangor, West Java, Indonesia; 5Faculty of Resource Science and Technology, Universiti Malaysia Sarawak, Kota Samarahan, MalaysiaCorrespondence: Anna Meiliana, Email [email protected]: Personalized nutrition, guided by nutrigenetic insights, is a promising strategy for optimizing immune function through targeted dietary interventions. Peripheral blood mononuclear cells (PBMCs), comprising lymphocytes and monocytes, serve as a dynamic model for investigating gene–diet interactions because of their sensitivity to nutritional and genetic influences. This review aimed to synthesize current reports on the interplay between genetic variation, dietary components, and PBMC molecular responses and evaluate the clinical applicability of the interaction in the development of individualized nutritional strategies for immune optimization. A structured and narrative-focused method was used to synthesize the literature, showing the relationship between molecular knowledge and practical solutions in personalized nutrition as well as immune system optimization, with a focus on PBMCs. A thorough search was performed on PubMed, Scopus, and Google Scholar, encompassing the years 2006 to 2025. Genetic polymorphisms in the vitamin D receptor (VDR), peroxisome proliferator-activated receptor (PPAR), superoxide dismutase 2 (SOD2), and Toll-like receptor 4 (TLR4) modulated the response of PBMCs to nutrients, including vitamin D, omega-3 fatty acids, antioxidants, and polyphenols. The discussion encompassed molecular pathways involving cytokine modulation, oxidative stress, and epigenetic alterations, highlighting PBMCs as indicators of immunological resistance and chronic disease susceptibility. The exploration of multiomics integration to achieve precision nutrition holds significant implications for clinical practice and public health. By using PBMC-based nutrigenetic profiling as a monitoring and stratification tool, future interventions may move toward more focused immune optimization and improved health outcomes, pending further validation in longitudinal and interventional studies.Keywords: nutrigenomics, genetic polymorphism, personalized nutrition, functional foods
SN - 1178-7066
ER -