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Peer-reviewedCC BYPLOS One

A liquid- and capsule-compatible hydroxyurea electronic monitor to identify non-adherent youth with sickle cell disease

  • Anyssa Young1
  • Nate Goldfarb1
  • Patrick McGann2
  • Sherif M Badawy3,4
  • Sebastian Seiguer5
  • Savannah Winkler3
  • Erika Huerta3
  • Lisbel Gonzalez6
  • Saige Armistead5
  • Susan Creary1,7
7 affiliations
  1. 1Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio, United States of America.
  2. 2Hasbro Children's Hospital, Pediatric Hematology/Oncology, Lifespan Comprehensive Sickle Cell Center, Providence, Rhode Island, United States of America.
  3. 3Ann & Robert H. Lurie Children's Hospital of Chicago, Division of Hematology, Oncology, and Stem Cell Transplant, Chicago, Illinois, United States of America.
  4. 4Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America.
  5. 5Scene Health, Brooklandville, Maryland, United States of America.
  6. 6Brown University Health, Pediatric Hematology and Oncology, Providence, Rhode Island, United States of America.
  7. 7Department of Hematology, Oncology, and Bone Marrow Transplant, Nationwide Children's Hospital, Columbus, Ohio, United States of America.
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Abstract

Prescription and claims data indicate that hydroxyurea (HU) adherence is low among youth with sickle cell disease (SCD). Electronic monitors (EM) are a gold standard measure, yet existing models have significant drawbacks that limit their use in youth with SCD. We developed a small, cellular-connected EM that is compatible with both liquid and capsule HU formulation bottles. In testing this EM among a sample of adolescents and young adults and caregivers of young children with SCD, we found that the EM is feasible and acceptable among youth with SCD and caregivers of young children with SCD in the short-term. We also found that the EM are useful for determining HU adherence and gained user insights that may improve their use longer-term. Future studies should examine the EM ability to determine which youth with SCD could most benefit from HU adherence intervention and treatment escalation in those with optimized adherence.

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Cite

BibTeXRIS
BibTeX
@article{young2026liquid,
  title = {{A liquid- and capsule-compatible hydroxyurea electronic monitor to identify non-adherent youth with sickle cell disease}},
  author = {Anyssa Young and Nate Goldfarb and Patrick McGann and Sherif M Badawy and Sebastian Seiguer and Savannah Winkler and Erika Huerta and Lisbel Gonzalez and Saige Armistead and Susan Creary},
  journal = {PLOS One},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pone.0358450},
  url = {https://doi.org/10.1371/journal.pone.0358450},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - A liquid- and capsule-compatible hydroxyurea electronic monitor to identify non-adherent youth with sickle cell disease
AU  - Anyssa Young
AU  - Nate Goldfarb
AU  - Patrick McGann
AU  - Sherif M Badawy
AU  - Sebastian Seiguer
AU  - Savannah Winkler
AU  - Erika Huerta
AU  - Lisbel Gonzalez
AU  - Saige Armistead
AU  - Susan Creary
PY  - 2026
DA  - 2026/10/21
JO  - PLOS One
DO  - 10.1371/journal.pone.0358450
UR  - https://doi.org/10.1371/journal.pone.0358450
AB  - Prescription and claims data indicate that hydroxyurea (HU) adherence is low among youth with sickle cell disease (SCD). Electronic monitors (EM) are a gold standard measure, yet existing models have significant drawbacks that limit their use in youth with SCD. We developed a small, cellular-connected EM that is compatible with both liquid and capsule HU formulation bottles. In testing this EM among a sample of adolescents and young adults and caregivers of young children with SCD, we found that the EM is feasible and acceptable among youth with SCD and caregivers of young children with SCD in the short-term. We also found that the EM are useful for determining HU adherence and gained user insights that may improve their use longer-term. Future studies should examine the EM ability to determine which youth with SCD could most benefit from HU adherence intervention and treatment escalation in those with optimized adherence.
SN  - 1932-6203
ER  -