Peer-reviewedCC BYJournal of cardiovascular and thoracic research30 Jun 2026

Association of Value of Fibrosis-4 Index with Long-Term Mortality in Patients with Heart Failure: A Comparison Study with Fibrosis-5 Index.

Halit Emre Yalvaç¹
Fatih Enes Durmaz²
Bektaş Murat¹
Selda Murat³

¹Department of Cardiology, Eskişehir City Hospital, Eskişehir, Turkey.
²Department of Cardiology, Muş State Hospital, Muş, Turkey.
³Department of Cardiology, Eskişehir Osmangazi University Hospital, Eskişehir, Turkey.

Abstract

Introduction

Fibrosis-4 (FIB-4) and fibrosis-5 (FIB-5) indices are non-invasive biomarkers originally developed for hepatic fibrosis but may reflect systemic pathophysiological changes related to adverse cardiovascular prognosis. We aimed to investigate whether baseline FIB-4 and FIB-5 values predict long-term mortality in patients with heart failure (HF).Methods

This retrospective observational study included 593 patients with HF who had available long-term mortality data. FIB-4 and FIB-5 indices were calculated at admission. Patients were followed for all-cause mortality, and outcomes were evaluated at 1-year, 3-year, and 5-year intervals. Clinical, laboratory, and echocardiographic parameters were compared between survivors and non-survivors.Results

During follow-up, 1-year, 3-year, and 5-year mortality rates were 24.6%, 39.0%, and 49.7%, respectively. Non-survivors had significantly higher FIB-4 and FIB-5 values compared with survivors (P<0.001 for both). ROC curve analyses demonstrated that both indices had significant predictive performance for long-term mortality. Optimal cut-off values showed good sensitivity and specificity for identifying high-risk patients.Conclusion

Higher FIB-4 and FIB-5 values are associated with greater long-term mortality risk in HF patients. These indices may serve as practical, cost-effective prognostic biomarkers for mortality risk stratification in routine clinical care.

Association of the Charlson Comorbidity Index and Age-Adjusted Charlson Comorbidity Index with Clinical Course and Mortality in Patients with Idiopathic Pulmonary Fibrosis
Tugba Onyilmaz, Gozde Oksuzler Kizilbay, Huseyin Kaya +4
Biomedicines25 Sep 2026Peer-reviewedCC BYFull textGeneral medicineEurope PMC
Association between fibrosis-4 index and 30-day all-cause mortality in critically ill patients hospitalised with acute heart failure: a retrospective cohort study from the MIMIC-IV database
Xiaotian Ren, Lei Li, Fei Liu +1
Postepy w kardiologii interwencyjnej = Advances in interventional cardiology30 Jul 2026Peer-reviewedCC BY-NC-SAFull textCardiovascular medicineEurope PMCPMC
Joint association of insulin resistance, fatty liver and fibrosis indices with MACE and mortality in individuals with Cardiovascular-Kidney-Metabolic syndrome stages 0-3.
Yanqiu Huang, Wen Gu, Yadan Xu +8
AIMS public health20 Jul 2026Peer-reviewedCC BYFull textEndocrinology & metabolismEurope PMC
Effect modification of gallbladder wall thickness on the association between fibrosis-4 index and high-risk colorectal adenoma in patients with gallbladder polyps: a retrospective cross-sectional study.
Wenting Xu, Shuang Chen, Lihong Wang
Frontiers in oncology7 Oct 2026Peer-reviewedCC BYFull textOncologyEurope PMCCrossref
Association between vitamin D deficiency and liver fibrosis assessed by transient elastography in patients with metabolic dysfunction-associated steatotic liver disease.
Justin Jose, Salman Muhammad Soomar, Ximena Fernandez Cristobal +1
BMC endocrine disorders31 Aug 2026Peer-reviewedCC BYFull textEpidemiology & public healthEurope PMCPMC

Cite

BibTeX RIS

BibTeX

@article{yalvac2026association,
  title = {{Association of Value of Fibrosis-4 Index with Long-Term Mortality in Patients with Heart Failure: A Comparison Study with Fibrosis-5 Index.}},
  author = {Halit Emre Yalvaç and Fatih Enes Durmaz and Bektaş Murat and Selda Murat},
  journal = {Journal of cardiovascular and thoracic research},
  year = {2026},
  month = jun,
  doi = {10.34172/jcvtr.33476},
  url = {https://europepmc.org/article/MED/42898407},
  note = {CC BY},
}

RIS

TY  - JOUR
TI  - Association of Value of Fibrosis-4 Index with Long-Term Mortality in Patients with Heart Failure: A Comparison Study with Fibrosis-5 Index.
AU  - Halit Emre Yalvaç
AU  - Fatih Enes Durmaz
AU  - Bektaş Murat
AU  - Selda Murat
PY  - 2026
DA  - 2026/06/30
JO  - Journal of cardiovascular and thoracic research
DO  - 10.34172/jcvtr.33476
UR  - https://europepmc.org/article/MED/42898407
AB  - Introduction  Fibrosis-4 (FIB-4) and fibrosis-5 (FIB-5) indices are non-invasive biomarkers originally developed for hepatic fibrosis but may reflect systemic pathophysiological changes related to adverse cardiovascular prognosis. We aimed to investigate whether baseline FIB-4 and FIB-5 values predict long-term mortality in patients with heart failure (HF).Methods  This retrospective observational study included 593 patients with HF who had available long-term mortality data. FIB-4 and FIB-5 indices were calculated at admission. Patients were followed for all-cause mortality, and outcomes were evaluated at 1-year, 3-year, and 5-year intervals. Clinical, laboratory, and echocardiographic parameters were compared between survivors and non-survivors.Results  During follow-up, 1-year, 3-year, and 5-year mortality rates were 24.6%, 39.0%, and 49.7%, respectively. Non-survivors had significantly higher FIB-4 and FIB-5 values compared with survivors (P<0.001 for both). ROC curve analyses demonstrated that both indices had significant predictive performance for long-term mortality. Optimal cut-off values showed good sensitivity and specificity for identifying high-risk patients.Conclusion  Higher FIB-4 and FIB-5 values are associated with greater long-term mortality risk in HF patients. These indices may serve as practical, cost-effective prognostic biomarkers for mortality risk stratification in routine clinical care.
SN  - 2008-5117
SN  - 2008-6830
ER  -

Abstract

Related

Cite