Skip to content
DraconiticResearch
Search Sources API
203,234 studies31 sourcesUpdated 28 min ago
Peer-reviewedCC BYAmerican journal of physiology. Gastrointestinal and liver physiology

Butyrate Triggers Neuronal Signaling via Release of Colonic Serotonin in a Microfluidic Model of Gut-Brain Axis

  • Awurama Ofori-Kwafo1
  • Hemaa Sree Kumar2,3,4
  • Emily B. Otmanowski3,4
  • Earshed Al Mamun1
  • Ajla Habibic-Beskovic4
  • Qiuhong Li5
  • Jasenka Zubcevic3,4
  • Yuan Tang1
5 affiliations
  1. 1Department of Bioengineering, College of Engineering, The University of Toledo, Toledo, Ohio, USA
  2. 2Department of Neurosciences, The University of Toledo, College of Medicine and Life Sciences, Toledo, Ohio, USA
  3. 3Center for Microbiome Research, Microbiomes Institute, University of South Florida, Tampa, FL, USA
  4. 4Department of Neurosurgery, Brain and Spine, Morsani College of Medicine, University of South Florida Tampa, FL, USA
  5. 5Department of Ophthalmology, College of Medicine, University of Florida, Gainesville, FL, USA
Read full textDOICite

Abstract

We present a compartmentalized microfluidic trichannel model of the gut-brain axis that reveals how microbial metabolites communicate with neurons. Using this model, we show that butyrate triggers colonic serotonin release, which activates neuronal signaling through calcium influx. This work highlights the power of microfluidic models to uncover mechanisms of gut-brain communication in a controlled, in vitro setting.

Related

  1. Prions Impair Bioaminergic Functions through Serotonin- or Catecholamine-derived Neurotoxins in Neuronal Cells
    Sophie Mouillet-Richard, Noriyuki Nishida, Elodie Pradines +7
    Journal of Biological ChemistryPeer-reviewedCC BYFull text33 citedMolecular biology & gene regulationHAL
  2. Clostridium butyricum and butyrate reprogram macrophages to alleviate obesity by disrupting the LPS-EGR1 axis and its associated PI3K-Akt signaling
    Wangchang Li, Wenxin Chen, Lu Wang +10
    MicrobiomePeer-reviewedCC BY-NC-ND 4.0Molecular biology & gene regulationCrossref
  3. Dietary butyrate alleviates high-fat diet-induced colonic mucosal impairment accompanied by increased gut-derived indole-3-acetic acid and enhanced PPARγ signaling
    Guoli Li, Sijing Dong, Chunhao Liu +5
    Frontiers in EndocrinologyPeer-reviewedCC BY 4.0Full textMolecular biology & gene regulationCrossrefEurope PMCPMC
  4. Intercellular GAS6-AXL signaling triggers podocyte cuproptosis in acute kidney injury upstream regulated by CEBPD
    Jingmei Liang, Yuyun Hu, Bing Liao
    PLOS OnePeer-reviewedCC BY 4.0Full textMolecular biology & gene regulationPhysiologyPLOS
  5. Folic acid polyglutamylation triggers MAP2K5 signaling to induce adipocyte lipid catabolism
    W. S. Kim, R. Danner, J. Cho +13
    bioRxivPreprintCC BY-NC-NDFull textGeneral biochemistrybioRxiv

Cite

BibTeXRIS
BibTeX
@article{oforikwafo2026butyrate,
  title = {{Butyrate Triggers Neuronal Signaling via Release of Colonic Serotonin in a Microfluidic Model of Gut-Brain Axis}},
  author = {Awurama Ofori-Kwafo and Hemaa Sree Kumar and Emily B. Otmanowski and Earshed Al Mamun and Ajla Habibic-Beskovic and Qiuhong Li and Jasenka Zubcevic and Yuan Tang},
  journal = {American journal of physiology. Gastrointestinal and liver physiology},
  year = {2026},
  month = sep,
  doi = {10.1152/ajpgi.00014.2026},
  url = {https://doi.org/10.1152/ajpgi.00014.2026},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Butyrate Triggers Neuronal Signaling via Release of Colonic Serotonin in a Microfluidic Model of Gut-Brain Axis
AU  - Awurama Ofori-Kwafo
AU  - Hemaa Sree Kumar
AU  - Emily B. Otmanowski
AU  - Earshed Al Mamun
AU  - Ajla Habibic-Beskovic
AU  - Qiuhong Li
AU  - Jasenka Zubcevic
AU  - Yuan Tang
PY  - 2026
DA  - 2026/09/30
JO  - American journal of physiology. Gastrointestinal and liver physiology
DO  - 10.1152/ajpgi.00014.2026
UR  - https://doi.org/10.1152/ajpgi.00014.2026
AB  - We present a compartmentalized microfluidic trichannel model of the gut-brain axis that reveals how microbial metabolites communicate with neurons. Using this model, we show that butyrate triggers colonic serotonin release, which activates neuronal signaling through calcium influx. This work highlights the power of microfluidic models to uncover mechanisms of gut-brain communication in a controlled, in vitro setting.
SN  - 0193-1857
SN  - 1522-1547
ER  -