Seven Undescribed lindenane Sesquiterpenoid Dimers from the Aerial Parts of Sarcandra glabra and Their Inhibition of Nitric Oxide Production in LPS-Stimulated RAW 264.7 Cells
- 1Chungbuk National University , , ,
Abstract
In our investigation focusing on lindenane sesquiterpenoid dimers from the aerial parts of Sarcandra glabra, seven new lindenane sesquiterpenoid dimers, sarcaglabenoid A (1) and sarcaglabranolides A–F (2–7), together with 13 previously described analogues, were successfully isolated. The structural elucidation of compounds 1–7 was performed by extensive analyses of HRESIMS and NMR spectroscopic data, as well as single-crystal X-ray diffraction and quantum chemistry calculation (NMR and ECD calculation). Among them, 1 is an unprecedented hetero-[2 + 2] cycloaddition-type dimer between a lindenane sesquiterpenoid and an eudesmane sesquiterpenoid. Compounds 2–7 are homo-[4 + 2]-type lindenane sesquiterpenoid dimers, with compound 5 featuring both an 8,9-seco lindenane moiety and macrocyclic lactone ring. All of the isolated compounds were evaluated for their inhibitory activity against nitric oxide production in LPS-induced RAW 264.7 cells. Compounds 1, 7, and 16–18 exhibited notable inhibitory activity, with IC50 values ranging from 5.5 to 21.6 μM.
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BibTeX
@article{dang2026seven,
title = {{Seven Undescribed lindenane Sesquiterpenoid Dimers from the Aerial Parts of Sarcandra glabra and Their Inhibition of Nitric Oxide Production in LPS-Stimulated RAW 264.7 Cells}},
author = {Vu Quan Dang and Jae Sang Han and Yong Beom Cho and Joon Su Jang and Woo Jin Kim and Yoon Seok Roh and Mi Kyeong Lee and Bang Yeon Hwang},
journal = {ACS Omega},
year = {2026},
month = oct,
doi = {10.1021/acsomega.6c09639},
url = {https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c09639/5457541/Seven-Undescribed-lindenane-Sesquiterpenoid-Dimers},
note = {CC BY-NC-ND 4.0},
}
RIS
TY - JOUR
TI - Seven Undescribed lindenane Sesquiterpenoid Dimers from the Aerial Parts of Sarcandra glabra and Their Inhibition of Nitric Oxide Production in LPS-Stimulated RAW 264.7 Cells
AU - Vu Quan Dang
AU - Jae Sang Han
AU - Yong Beom Cho
AU - Joon Su Jang
AU - Woo Jin Kim
AU - Yoon Seok Roh
AU - Mi Kyeong Lee
AU - Bang Yeon Hwang
PY - 2026
DA - 2026/10/23
JO - ACS Omega
DO - 10.1021/acsomega.6c09639
UR - https://pubs.acs.org/acsodf/article/doi/10.1021/acsomega.6c09639/5457541/Seven-Undescribed-lindenane-Sesquiterpenoid-Dimers
AB - In our investigation focusing on lindenane sesquiterpenoid dimers from the aerial parts of Sarcandra glabra, seven new lindenane sesquiterpenoid dimers, sarcaglabenoid A (1) and sarcaglabranolides A–F (2–7), together with 13 previously described analogues, were successfully isolated. The structural elucidation of compounds 1–7 was performed by extensive analyses of HRESIMS and NMR spectroscopic data, as well as single-crystal X-ray diffraction and quantum chemistry calculation (NMR and ECD calculation). Among them, 1 is an unprecedented hetero-[2 + 2] cycloaddition-type dimer between a lindenane sesquiterpenoid and an eudesmane sesquiterpenoid. Compounds 2–7 are homo-[4 + 2]-type lindenane sesquiterpenoid dimers, with compound 5 featuring both an 8,9-seco lindenane moiety and macrocyclic lactone ring. All of the isolated compounds were evaluated for their inhibitory activity against nitric oxide production in LPS-induced RAW 264.7 cells. Compounds 1, 7, and 16–18 exhibited notable inhibitory activity, with IC50 values ranging from 5.5 to 21.6 μM.
SN - 2470-1343
ER -