Special AT-rich sequence-binding protein 2-positive primary small cell neuroendocrine carcinoma of the urinary bladder: A diagnostic pitfall.
- 1Department of Pathology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
Abstract
Special AT-rich sequence-binding protein 2 (SATB2) expression in conjunction with CK20 expression has been established as a specific marker for the detection of colorectal adenocarcinomas. Recently, its expression in foregut, midgut, and hindgut neuroendocrine neoplasms has been documented. SATB2 expression has been documented in neuroendocrine neoplasms from various primary sites; however, its expression in the urinary bladder has not been reported. A case of primary small cell neuroendocrine carcinoma of the urinary bladder (SmCCB) is presented, where strong SATB2 expression led to the suspicion of metastatic neuroendocrine carcinomatous deposits from the lower gastrointestinal tract. However, on positron emission tomography-computed tomography scan, no fluorodeoxyglucose-avid lesion elsewhere in the body was found, which established the diagnosis of primary SmCCB with SATB2 expression.
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BibTeX
@article{soni2026special,
title = {{Special AT-rich sequence-binding protein 2-positive primary small cell neuroendocrine carcinoma of the urinary bladder: A diagnostic pitfall.}},
author = {Ankita Soni and Aminder Singh and Harpreet Kaur},
journal = {Indian journal of urology : IJU : journal of the Urological Society of India},
year = {2026},
month = sep,
doi = {10.4103/iju.iju_354_26},
url = {https://europepmc.org/article/MED/42910386},
note = {CC BY-NC-SA},
}
RIS
TY - JOUR
TI - Special AT-rich sequence-binding protein 2-positive primary small cell neuroendocrine carcinoma of the urinary bladder: A diagnostic pitfall.
AU - Ankita Soni
AU - Aminder Singh
AU - Harpreet Kaur
PY - 2026
DA - 2026/09/29
JO - Indian journal of urology : IJU : journal of the Urological Society of India
DO - 10.4103/iju.iju_354_26
UR - https://europepmc.org/article/MED/42910386
AB - Special AT-rich sequence-binding protein 2 (SATB2) expression in conjunction with CK20 expression has been established as a specific marker for the detection of colorectal adenocarcinomas. Recently, its expression in foregut, midgut, and hindgut neuroendocrine neoplasms has been documented. SATB2 expression has been documented in neuroendocrine neoplasms from various primary sites; however, its expression in the urinary bladder has not been reported. A case of primary small cell neuroendocrine carcinoma of the urinary bladder (SmCCB) is presented, where strong SATB2 expression led to the suspicion of metastatic neuroendocrine carcinomatous deposits from the lower gastrointestinal tract. However, on positron emission tomography-computed tomography scan, no fluorodeoxyglucose-avid lesion elsewhere in the body was found, which established the diagnosis of primary SmCCB with SATB2 expression.
SN - 0970-1591
SN - 1998-3824
ER -