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Peer-reviewedCC BY-NC 4.0BMJ Open

Effects of β-hydroxy-β-methylbutyrate (HMB) and/or 2-hydroxybenzylamine (2-HOBA) on markers of healthspan in older adults (H2AGE trial): study protocol of a randomised controlled trial at the Canadian Translational Geroscience Network

  • Guy Hajj-Boutros1,2
  • Sarah Birtulescu1
  • Sharmila Balram1
  • Andréa Faust1
  • Lucie Roussel3
  • Stephane Bernier3
  • Yichun Sun3
  • Laura Vaugeois3
  • Donald C Vinh3
  • José A Morais1,4
  • Tyler A Churchward-Venne1,5
  • Richard Kremer1
9 more authors
  • Giles Gouspillou6
  • Naji Abumrad2
  • John Rathmacher7
  • Darren Candow8
  • Jennifer Watt9
  • Alexandra Papaioannou10
  • Manuel Montero-Odasso11
  • Chris McGlory12
  • Gustavo Duque1,4
12 affiliations
  1. 1Bone, Muscle & Geroscience Group, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
  2. 2Department of Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA
  3. 3Meakins-Christie Laboratories, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada
  4. 4Division of Geriatric Medicine, McGill University, Montreal, Quebec, Canada
  5. 5Department of Kinesiology and Physical Education, McGill University, Montreal, Quebec, Canada
  6. 6Département des Sciences de l’Activité Physique, UQAM, Montreal, Quebec, Canada
  7. 7TSI Group Ltd, Ames, Iowa, USA
  8. 8Faculty of Kinesiology and Health Studies, University of Regina, Regina, Saskatchewan, Canada
  9. 9Medicine, University of Toronto, Toronto, Ontario, Canada
  10. 10Medicine, McMaster University, Hamilton, Ontario, Canada
  11. 11Medicine (Geriatrics) and Epidemiology and Biostatistics, Western University, London, Ontario, Canada
  12. 12School of Kinesiology and Health Studies, Queen’s University, Kingston, Ontario, Canada
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Cite

BibTeXRIS
BibTeX
@article{hajjboutros2026effects,
  title = {{Effects of β-hydroxy-β-methylbutyrate (HMB) and/or 2-hydroxybenzylamine (2-HOBA) on markers of healthspan in older adults (H2AGE trial): study protocol of a randomised controlled trial at the Canadian Translational Geroscience Network}},
  author = {Guy Hajj-Boutros and Sarah Birtulescu and Sharmila Balram and Andréa Faust and Lucie Roussel and Stephane Bernier and Yichun Sun and Laura Vaugeois and Donald C Vinh and José A Morais and Tyler A Churchward-Venne and Richard Kremer and Giles Gouspillou and Naji Abumrad and John Rathmacher and Darren Candow and Jennifer Watt and Alexandra Papaioannou and Manuel Montero-Odasso and Chris McGlory and Gustavo Duque},
  journal = {BMJ Open},
  year = {2026},
  month = oct,
  doi = {10.1136/bmjopen-2026-119962},
  url = {https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2026-119962},
  note = {CC BY-NC 4.0},
}
RIS
TY  - JOUR
TI  - Effects of β-hydroxy-β-methylbutyrate (HMB) and/or 2-hydroxybenzylamine (2-HOBA) on markers of healthspan in older adults (H2AGE trial): study protocol of a randomised controlled trial at the Canadian Translational Geroscience Network
AU  - Guy Hajj-Boutros
AU  - Sarah Birtulescu
AU  - Sharmila Balram
AU  - Andréa Faust
AU  - Lucie Roussel
AU  - Stephane Bernier
AU  - Yichun Sun
AU  - Laura Vaugeois
AU  - Donald C Vinh
AU  - José A Morais
AU  - Tyler A Churchward-Venne
AU  - Richard Kremer
AU  - Giles Gouspillou
AU  - Naji Abumrad
AU  - John Rathmacher
AU  - Darren Candow
AU  - Jennifer Watt
AU  - Alexandra Papaioannou
AU  - Manuel Montero-Odasso
AU  - Chris McGlory
AU  - Gustavo Duque
PY  - 2026
DA  - 2026/10/12
JO  - BMJ Open
DO  - 10.1136/bmjopen-2026-119962
UR  - https://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2026-119962
SN  - 2044-6055
SN  - 2044-6055
ER  -