Polymorphism can extensively reshape the genome-wide crossover landscape in Arabidopsis thaliana
Abstract
Meiotic recombination, via the formation of crossovers (COs), re-assorts parental alleles and dictate which traits are inherited together, or not. The recombination rate is not homogeneous across the genome, and uncovering the causes of these fluctuations can inform our understanding of recombination and genome evolution. In this study we show that presence of sequence divergence (polymorphism) between homologous chromosomes can dictate where crossovers are formed in Arabidopsis thaliana. Indeed, presence of polymorphism increases the local recombination rate, turning cold regions of the genome hot. This relocation occurs at the expense of non-polymorphic regions, which become colder. This global overhaul of the CO landscape is dependent on the mismatch repair (MMR) machinery. This suggests that MMR has a pro-CO role, driving COs to regions of the genome where it could detect sequence differences between homologous chromosomes. Our study demonstrates that polymorphism can be a major recombination driver in A. thaliana.
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BibTeX
@misc{madec2026polymorphism,
title = {{Polymorphism can extensively reshape the genome-wide crossover landscape in Arabidopsis thaliana}},
author = {Benoît Madec and Maëla Sémery and Qichao Lian and Mohamad Yassine and Loïse Léonard-Moniot and Éric Espagne and Sophie Piquerez and Chloé Girard},
howpublished = {Nature Communications},
year = {2026},
month = aug,
doi = {10.1101/2025.09.19.677288},
url = {https://cnrs.hal.science/hal-05760223v1},
note = {CC BY-NC-SA 4.0},
}
RIS
TY - UNPB
TI - Polymorphism can extensively reshape the genome-wide crossover landscape in Arabidopsis thaliana
AU - Benoît Madec
AU - Maëla Sémery
AU - Qichao Lian
AU - Mohamad Yassine
AU - Loïse Léonard-Moniot
AU - Éric Espagne
AU - Sophie Piquerez
AU - Chloé Girard
PY - 2026
DA - 2026/08/01
PB - Nature Communications
DO - 10.1101/2025.09.19.677288
UR - https://cnrs.hal.science/hal-05760223v1
AB - Meiotic recombination, via the formation of crossovers (COs), re-assorts parental alleles and dictate which traits are inherited together, or not. The recombination rate is not homogeneous across the genome, and uncovering the causes of these fluctuations can inform our understanding of recombination and genome evolution. In this study we show that presence of sequence divergence (polymorphism) between homologous chromosomes can dictate where crossovers are formed in Arabidopsis thaliana. Indeed, presence of polymorphism increases the local recombination rate, turning cold regions of the genome hot. This relocation occurs at the expense of non-polymorphic regions, which become colder. This global overhaul of the CO landscape is dependent on the mismatch repair (MMR) machinery. This suggests that MMR has a pro-CO role, driving COs to regions of the genome where it could detect sequence differences between homologous chromosomes. Our study demonstrates that polymorphism can be a major recombination driver in A. thaliana.
SN - 2041-1723
SN - 2041-1723
ER -