Bone Morphogenetic Protein-10 as a Predictor of Atrial Fibrillation Recurrence After Catheter Ablation: A Systematic Review and Meta-Analysis.
- 1Department of Internal Medicine, Geisinger Wyoming Valley Hospital, Wilkes-Barre, PA 18711, USA.
- 2Department of Cardiology, Geisinger Wyoming Valley Hospital, Wilkes-Barre, PA 18711, USA.
- 3Department of Sciences, University of Kashmir, Srinagar, India.
Abstract
Background
Biomarkers of atrial cardiomyopathy may improve the prediction of recurrence of atrial fibrillation (AF) after catheter ablation. Bone morphogenetic protein-10 (BMP10) is an atrial-specific cardiomyocyte protein and a potential biomarker, but evidence is limited and not comprehensively synthesized.Methods
We performed a systematic review and meta-analysis of prospective cohort studies to evaluate the association between circulating BMP10 concentrations with AF recurrence after catheter ablation. Pooled hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were computed using a random-effects model. The primary analysis used unadjusted HRs per continuous BMP10 levels from all included studies. Secondary analyses were conducted based on the adjusted HRs of studies with continuous BMP10 and all studies, including one study that reported adjusted HRs based on quartiles.Results
Three studies were included. In the primary analysis without adjustment (n = 3), increased levels of BMP10 were significantly associated with recurrence of AF (pooled HR 1.53, 95% CI 1.13-2.07; P = 0.006), with moderate-to-high heterogeneity (I² = 69%). The association was attenuated and non-significant in the adjusted analysis of two studies with continuous BMP10 (HR 1.46, 95% CI 0.94-2.25; I² = 59%). However, after the inclusion of a third study with adjusted quartile-based HR, the statistical significance was re-demonstrated (HR 1.33, 95% CI 1.16-1.53; P < 0.001) with low heterogeneity (I² = 20%).Conclusion
Elevated BMP10 levels are correlated with higher risk of AF recurrence following catheter ablation. Although the results are consistent across analyses, they should be interpreted with caution due to the small number of studies and methodological heterogeneity. BMP10 needs to be confirmed as a clinically applicable biomarker by larger prospective studies.
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BibTeX
@article{mohsin2026bone,
title = {{Bone Morphogenetic Protein-10 as a Predictor of Atrial Fibrillation Recurrence After Catheter Ablation: A Systematic Review and Meta-Analysis.}},
author = {Naveed Mohsin and Martin Eugene Matsumura and Tariq Ahmad and Kaif Ul Sahar},
journal = {Journal of clinical medicine research},
year = {2026},
month = sep,
doi = {10.14740/jocmr6640},
url = {https://europepmc.org/article/MED/42872227},
note = {CC BY},
}
RIS
TY - JOUR
TI - Bone Morphogenetic Protein-10 as a Predictor of Atrial Fibrillation Recurrence After Catheter Ablation: A Systematic Review and Meta-Analysis.
AU - Naveed Mohsin
AU - Martin Eugene Matsumura
AU - Tariq Ahmad
AU - Kaif Ul Sahar
PY - 2026
DA - 2026/09/26
JO - Journal of clinical medicine research
DO - 10.14740/jocmr6640
UR - https://europepmc.org/article/MED/42872227
AB - Background Biomarkers of atrial cardiomyopathy may improve the prediction of recurrence of atrial fibrillation (AF) after catheter ablation. Bone morphogenetic protein-10 (BMP10) is an atrial-specific cardiomyocyte protein and a potential biomarker, but evidence is limited and not comprehensively synthesized.Methods We performed a systematic review and meta-analysis of prospective cohort studies to evaluate the association between circulating BMP10 concentrations with AF recurrence after catheter ablation. Pooled hazard ratios (HRs) with corresponding 95% confidence intervals (CIs) were computed using a random-effects model. The primary analysis used unadjusted HRs per continuous BMP10 levels from all included studies. Secondary analyses were conducted based on the adjusted HRs of studies with continuous BMP10 and all studies, including one study that reported adjusted HRs based on quartiles.Results Three studies were included. In the primary analysis without adjustment (n = 3), increased levels of BMP10 were significantly associated with recurrence of AF (pooled HR 1.53, 95% CI 1.13-2.07; P = 0.006), with moderate-to-high heterogeneity (I² = 69%). The association was attenuated and non-significant in the adjusted analysis of two studies with continuous BMP10 (HR 1.46, 95% CI 0.94-2.25; I² = 59%). However, after the inclusion of a third study with adjusted quartile-based HR, the statistical significance was re-demonstrated (HR 1.33, 95% CI 1.16-1.53; P < 0.001) with low heterogeneity (I² = 20%).Conclusion Elevated BMP10 levels are correlated with higher risk of AF recurrence following catheter ablation. Although the results are consistent across analyses, they should be interpreted with caution due to the small number of studies and methodological heterogeneity. BMP10 needs to be confirmed as a clinically applicable biomarker by larger prospective studies.
SN - 1918-3003
SN - 1918-3011
ER -