Personalised prediction of anomalous bone regeneration in multiple myeloma patients
- 1Queen Mary University of London
Abstract
Recent advances in immunotherapies have dramatically extended the lives of patients with multiple myeloma, resulting in a growing population of elderly patients suffering from damage to their vertebrae caused by this blood cancer. Clinicians typically intervene to fill in these lytic lesions in an attempt to reduce the risk of vertebral collapse and spinal cord injury, however observations of rapid bone regeneration post-cancer treatment suggest that surgery may not always be required. Here we develop a series of mechanistic computational models, optimised using cohorts of healthy volunteer and patient data, to show that vertebrae of recovering multiple myeloma patients rapidly strengthen in a manner not entirely explained by known bone remodelling mechanisms. Furthermore, using pathways informed by genomics data and patient-specific bone biomarkers, we demonstrate the potential for these models to provide personalised predictions of bone disease trajectory.
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BibTeX
@misc{gibson2026personalised,
title = {{Personalised prediction of anomalous bone regeneration in multiple myeloma patients}},
author = {F. Gibson and R. E. Andrews and M. A. Lawson and A. Chantry and J. Brown and C. Handforth and P. Thayaparan and M. Paggiosi and S. Molloy and J. Shelton and X. Li and E. Dall'Ara and S. W. Verbruggen},
howpublished = {bioRxiv},
year = {2026},
month = oct,
doi = {10.64898/2026.10.26.761863},
url = {https://www.biorxiv.org/content/10.64898/2026.10.26.761863v1},
note = {CC BY},
}
RIS
TY - UNPB
TI - Personalised prediction of anomalous bone regeneration in multiple myeloma patients
AU - F. Gibson
AU - R. E. Andrews
AU - M. A. Lawson
AU - A. Chantry
AU - J. Brown
AU - C. Handforth
AU - P. Thayaparan
AU - M. Paggiosi
AU - S. Molloy
AU - J. Shelton
AU - X. Li
AU - E. Dall'Ara
AU - S. W. Verbruggen
PY - 2026
DA - 2026/10/26
PB - bioRxiv
DO - 10.64898/2026.10.26.761863
UR - https://www.biorxiv.org/content/10.64898/2026.10.26.761863v1
AB - Recent advances in immunotherapies have dramatically extended the lives of patients with multiple myeloma, resulting in a growing population of elderly patients suffering from damage to their vertebrae caused by this blood cancer. Clinicians typically intervene to fill in these lytic lesions in an attempt to reduce the risk of vertebral collapse and spinal cord injury, however observations of rapid bone regeneration post-cancer treatment suggest that surgery may not always be required. Here we develop a series of mechanistic computational models, optimised using cohorts of healthy volunteer and patient data, to show that vertebrae of recovering multiple myeloma patients rapidly strengthen in a manner not entirely explained by known bone remodelling mechanisms. Furthermore, using pathways informed by genomics data and patient-specific bone biomarkers, we demonstrate the potential for these models to provide personalised predictions of bone disease trajectory.
ER -