Gene and microRNA Expression Profiling in Experimental Colitis and Human Ulcerative Colitis: Effects of STAT6 Knockout and Corylus avellana Treatment
4 affiliations
- 1Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 050095 Bucharest, Romania
- 2Department of Gastroenterology, Elias Emergency University Hospital, 011461 Bucharest, Romania
- 3“Aurel Ardelean” Institute of Life Sciences, Vasile Goldis Western University, 310414 Arad, Romania
- 4Research Institute of the University of Bucharest, 050663 Bucharest, Romania
Abstract
Inflammatory bowel diseases (IBDs) are chronic immune-mediated disorders of the gastrointestinal tract resulting from a complex interplay between genetic susceptibility and dysregulated immune responses. To improve the understanding of the molecular mechanisms’ underlying disease pathogenesis, mouse models with experimental colitis and patients with ulcerative colitis (UC) were investigated for the expression of genes and small non-coding RNAs involved in key pathogenic pathways. In experimental colitis, the potential modulatory effects of STAT6 knockout and Corylus avellana treatment were also evaluated. Our findings revealed significant transcriptional alterations in molecular markers associated with inflammation, epithelial barrier integrity, autophagy, and endoplasmic reticulum stress, highlighting their association with the development and persistence of chronic intestinal inflammation. Both STAT6 deletion and Corylus avellana extract treatment modulated several of these alterations, with STAT6 knockout showing a more pronounced effect on the molecular profile associated with experimental colitis. In addition, miRNA expression profiling revealed a panel of dysregulated miRNAs, while bioinformatic analysis identified potential miRNA-gene regulatory interactions, supporting their possible involvement in the post-transcriptional regulation of these biological processes. Overall, the combined analysis of gene and miRNA expression profiles highlights molecular alterations associated with experimental colitis and human UC and suggests potential regulatory interactions that require further experimental validation.
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BibTeX
@article{samoila2026gene,
title = {{Gene and microRNA Expression Profiling in Experimental Colitis and Human Ulcerative Colitis: Effects of STAT6 Knockout and Corylus avellana Treatment}},
author = {Iuliana Samoilă and Cristian George Țieranu and Anca Hermenean and Sorina Dinescu},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = oct,
doi = {10.3390/ijms27219411},
url = {https://www.mdpi.com/1422-0067/27/21/9411},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Gene and microRNA Expression Profiling in Experimental Colitis and Human Ulcerative Colitis: Effects of STAT6 Knockout and Corylus avellana Treatment
AU - Iuliana Samoilă
AU - Cristian George Țieranu
AU - Anca Hermenean
AU - Sorina Dinescu
PY - 2026
DA - 2026/10/22
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27219411
UR - https://www.mdpi.com/1422-0067/27/21/9411
AB - Inflammatory bowel diseases (IBDs) are chronic immune-mediated disorders of the gastrointestinal tract resulting from a complex interplay between genetic susceptibility and dysregulated immune responses. To improve the understanding of the molecular mechanisms’ underlying disease pathogenesis, mouse models with experimental colitis and patients with ulcerative colitis (UC) were investigated for the expression of genes and small non-coding RNAs involved in key pathogenic pathways. In experimental colitis, the potential modulatory effects of STAT6 knockout and Corylus avellana treatment were also evaluated. Our findings revealed significant transcriptional alterations in molecular markers associated with inflammation, epithelial barrier integrity, autophagy, and endoplasmic reticulum stress, highlighting their association with the development and persistence of chronic intestinal inflammation. Both STAT6 deletion and Corylus avellana extract treatment modulated several of these alterations, with STAT6 knockout showing a more pronounced effect on the molecular profile associated with experimental colitis. In addition, miRNA expression profiling revealed a panel of dysregulated miRNAs, while bioinformatic analysis identified potential miRNA-gene regulatory interactions, supporting their possible involvement in the post-transcriptional regulation of these biological processes. Overall, the combined analysis of gene and miRNA expression profiles highlights molecular alterations associated with experimental colitis and human UC and suggests potential regulatory interactions that require further experimental validation.
SN - 1422-0067
ER -