Molecular Regulators for the Wnt/β-Catenin Signalling Pathway for Bone Remodelling in Periodontitis: A Scoping Review
4 affiliations
- 1Department of Craniofacial Diagnostics and Biosciences, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia
- 2Department of Restorative Dentistry, Faculty of Dentistry, Universiti Kebangsaan Malaysia, Kuala Lumpur 50300, Malaysia
- 3Centre for Diagnostics, Therapeutics, and Investigative Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia
- 4Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, Kuala Lumpur 56000, Malaysia
Abstract
Periodontitis is a chronic inflammatory disease that destroys the periodontal ligament, leading to alveolar bone loss and ultimately tooth loss. The Wnt/β-catenin signalling pathway is an important molecular signalling pathway that controls the expression of bone remodelling-related genes. Manipulating this pathway is a recurring theme in recent studies, suggesting a viable therapeutic target. A scoping review was conducted according to PRISMA guidelines to identify the latest molecular regulators used in manipulating the signalling pathway between 2007 and 2025 from databases such as Web of Science, Ovid Medline, and Scopus. Only primary articles relevant to the signalling pathway, periodontitis, and bone homeostasis were selected. A total of 22 articles were identified, using various molecules ranging from plant extracts such as field horsetail to pre-existing drugs. The molecules function by altering the activities of targets within the signalling pathway such as β-catenin and GSK-3β phosphorylation, ultimately increasing osteoblast differentiation for bone growth that was reduced in periodontitis cases. The Wnt/β-catenin signalling pathway is a favoured target for potential therapeutic interventions for periodontitis. However, most studies are limited to in vitro methods and requires further description on the relationships between periodontitis and the signalling pathway.
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BibTeX
@article{maeraj2026molecular,
title = {{Molecular Regulators for the Wnt/β-Catenin Signalling Pathway for Bone Remodelling in Periodontitis: A Scoping Review}},
author = {Hasif Amir Maeraj and Shivaroobini Rajoo and Shahida Mohd-Said and Nurrul Shaqinah Nasruddin and Izatus Shima Taib and Sok Kuan Wong and Putri Ayu Jayusman},
journal = {International Journal of Molecular Sciences},
year = {2026},
month = oct,
doi = {10.3390/ijms27209117},
url = {https://www.mdpi.com/1422-0067/27/20/9117},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Molecular Regulators for the Wnt/β-Catenin Signalling Pathway for Bone Remodelling in Periodontitis: A Scoping Review
AU - Hasif Amir Maeraj
AU - Shivaroobini Rajoo
AU - Shahida Mohd-Said
AU - Nurrul Shaqinah Nasruddin
AU - Izatus Shima Taib
AU - Sok Kuan Wong
AU - Putri Ayu Jayusman
PY - 2026
DA - 2026/10/01
JO - International Journal of Molecular Sciences
DO - 10.3390/ijms27209117
UR - https://www.mdpi.com/1422-0067/27/20/9117
AB - Periodontitis is a chronic inflammatory disease that destroys the periodontal ligament, leading to alveolar bone loss and ultimately tooth loss. The Wnt/β-catenin signalling pathway is an important molecular signalling pathway that controls the expression of bone remodelling-related genes. Manipulating this pathway is a recurring theme in recent studies, suggesting a viable therapeutic target. A scoping review was conducted according to PRISMA guidelines to identify the latest molecular regulators used in manipulating the signalling pathway between 2007 and 2025 from databases such as Web of Science, Ovid Medline, and Scopus. Only primary articles relevant to the signalling pathway, periodontitis, and bone homeostasis were selected. A total of 22 articles were identified, using various molecules ranging from plant extracts such as field horsetail to pre-existing drugs. The molecules function by altering the activities of targets within the signalling pathway such as β-catenin and GSK-3β phosphorylation, ultimately increasing osteoblast differentiation for bone growth that was reduced in periodontitis cases. The Wnt/β-catenin signalling pathway is a favoured target for potential therapeutic interventions for periodontitis. However, most studies are limited to in vitro methods and requires further description on the relationships between periodontitis and the signalling pathway.
SN - 1422-0067
ER -