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Peer-reviewedCC BYMedical Mycology Case Reports

Laryngeal cryptococcosis with clinical failure to fluconazole in a patient with common variable immunodeficiency: A treatment dilemma

  • Rija Binte Rehan Alvi1
  • Ross M. Mayerhoff2
  • Eloy E. Ordaya3
  1. 1Henry Ford Hospital, Division of Infectious Diseases, 2799 W Grand Blv, Detroit, MI, 48322, USA
  2. 2Henry Ford Hospital, Department of Otolaryngology, 2799 W Grand Blv, Detroit, MI, 48322, USA
  3. 3Henry Ford Hospital, Division of Infectious Diseases, 2799 W Grand Blv, Detroit, MI, 48322, USA; Corresponding author. 2799 W Grand Blvd, CFP-322, Detroit, MI, 48202, USA.
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Abstract

We describe the case of a 57-year-old female with chronic hoarseness and cough whose laryngeal exam revealed chronic laryngitis with exudates. She failed multiple courses of fluconazole for presumed laryngeal candidiasis. Pathology demonstrated laryngeal cryptococcosis, and sputum cultures grew Cryptococcus neoformans with an elevated fluconazole MIC. Immunological evaluation led to the diagnosis of common variable immunodeficiency. After complications with alternative antifungals, the patient responded favorably to isavuconazole and intravenous immunoglobulin replacement.

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Cite

BibTeXRIS
BibTeX
@article{alvi2026laryngeal,
  title = {{Laryngeal cryptococcosis with clinical failure to fluconazole in a patient with common variable immunodeficiency: A treatment dilemma}},
  author = {Rija Binte Rehan Alvi and Ross M. Mayerhoff and Eloy E. Ordaya},
  journal = {Medical Mycology Case Reports},
  year = {2026},
  month = oct,
  doi = {10.1016/j.mmcr.2026.100831},
  url = {https://doi.org/10.1016/j.mmcr.2026.100831},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Laryngeal cryptococcosis with clinical failure to fluconazole in a patient with common variable immunodeficiency: A treatment dilemma
AU  - Rija Binte Rehan Alvi
AU  - Ross M. Mayerhoff
AU  - Eloy E. Ordaya
PY  - 2026
DA  - 2026/10/31
JO  - Medical Mycology Case Reports
DO  - 10.1016/j.mmcr.2026.100831
UR  - https://doi.org/10.1016/j.mmcr.2026.100831
AB  - We describe the case of a 57-year-old female with chronic hoarseness and cough whose laryngeal exam revealed chronic laryngitis with exudates. She failed multiple courses of fluconazole for presumed laryngeal candidiasis. Pathology demonstrated laryngeal cryptococcosis, and sputum cultures grew Cryptococcus neoformans with an elevated fluconazole MIC. Immunological evaluation led to the diagnosis of common variable immunodeficiency. After complications with alternative antifungals, the patient responded favorably to isavuconazole and intravenous immunoglobulin replacement.
SN  - 2211-7539
ER  -