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Peer-reviewedCC BYCommunications Biology

Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma

  • B. A. Helling
  • D. R. Sobreira
  • G. T. Hansen
  • N. J. Sakabe
  • K. Luo
  • C. Billstrand
  • B. Laxman
  • R. I. Nicolae
  • D. L. Nicolae
  • Y. A. Bochkov
  • J. E. Gern
  • M. A. Nobrega
2 more authors
  • S. R. White
  • C. Ober
Open at sourcePDFDOICite

Abstract

There is a life-long relationship between rhinovirus (RV) infection and the development and clinical manifestations of asthma. In this study we demonstrate that cultured primary bronchial epithelial cells from adults with asthma (n = 9) show different transcriptional and chromatin responses to RV infection compared to those without asthma (n = 9). Both the number and magnitude of transcriptional and chromatin responses to RV were muted in cells from asthma cases compared to controls. Pathway analysis of the transcriptionally responsive genes revealed enrichments of apoptotic pathways in controls but inflammatory pathways in asthma cases. Using promoter capture Hi-C we tethered regions of RV-responsive chromatin to RV-responsive genes and showed enrichment of these regions and genes at asthma GWAS loci. Taken together, our studies indicate a delayed or prolonged inflammatory state in cells from asthma cases and highlight genes that may contribute to genetic risk for asthma.

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Cite

BibTeXRIS
BibTeX
@article{helling2026altered,
  title = {{Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma}},
  author = {B. A. Helling and D. R. Sobreira and G. T. Hansen and N. J. Sakabe and K. Luo and C. Billstrand and B. Laxman and R. I. Nicolae and D. L. Nicolae and Y. A. Bochkov and J. E. Gern and M. A. Nobrega and S. R. White and C. Ober},
  journal = {Communications Biology},
  year = {2026},
  month = oct,
  doi = {10.1038/s42003-020-01411-4},
  url = {https://hal.science/hal-05787877v1},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Altered transcriptional and chromatin responses to rhinovirus in bronchial epithelial cells from adults with asthma
AU  - B. A. Helling
AU  - D. R. Sobreira
AU  - G. T. Hansen
AU  - N. J. Sakabe
AU  - K. Luo
AU  - C. Billstrand
AU  - B. Laxman
AU  - R. I. Nicolae
AU  - D. L. Nicolae
AU  - Y. A. Bochkov
AU  - J. E. Gern
AU  - M. A. Nobrega
AU  - S. R. White
AU  - C. Ober
PY  - 2026
DA  - 2026/10/09
JO  - Communications Biology
DO  - 10.1038/s42003-020-01411-4
UR  - https://hal.science/hal-05787877v1
AB  - There is a life-long relationship between rhinovirus (RV) infection and the development and clinical manifestations of asthma. In this study we demonstrate that cultured primary bronchial epithelial cells from adults with asthma (n = 9) show different transcriptional and chromatin responses to RV infection compared to those without asthma (n = 9). Both the number and magnitude of transcriptional and chromatin responses to RV were muted in cells from asthma cases compared to controls. Pathway analysis of the transcriptionally responsive genes revealed enrichments of apoptotic pathways in controls but inflammatory pathways in asthma cases. Using promoter capture Hi-C we tethered regions of RV-responsive chromatin to RV-responsive genes and showed enrichment of these regions and genes at asthma GWAS loci. Taken together, our studies indicate a delayed or prolonged inflammatory state in cells from asthma cases and highlight genes that may contribute to genetic risk for asthma.
SN  - 2399-3642
ER  -