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Peer-reviewedCC BY 4.0Nutrients

Nutraceuticals and Metabolic Health: Can Supplements Prevent Metabolic Syndrome? A Narrative Review

  • Andrew J. Krentz1
  • Oleksii Kozhevnikov2
  • Jennifer E. McCallum3
  • Lylah Drummond-Clarke3,4
  • Megan Fant5
  • Jing Han Ong3
  • Sital Harris6
  • Steven Walker3,7
7 affiliations
  1. 1School of Life Course & Population Sciences, King’s College London, Strand, London WC2R 2LS, UK
  2. 2MedibiotiX GmbH, Dr.-Reckeweg-Str. 2-4, 76532 Baden-Baden, Germany
  3. 3St Gilesmedical London & Berlin, Suite 616, The Shepherds Building, Charecroft Way, West Kensington, London W14 0EE, UK
  4. 4School of Life Sciences, University of Sussex, Brighton BN1 9RH, UK
  5. 5School of Life Sciences, University of Dundee, Carnelley Building, Dundee DD1 4HN, UK
  6. 6Life Science Academy, Eastbourne, East Sussex BN21 3FG, UK
  7. 7Medical School, University College London, 74 Huntley St, London WC1E 6DE, UK
Open at sourceDOICite

Abstract

Metabolic syndrome (MetS) encompasses a spectrum of disease pathologies that include dyslipidaemia, insulin resistance, hypertension, obesity, and inflammation. The rising prevalence of MetS and the associated morbidity and mortality represent a growing burden on global healthcare. MetS’s hallmarks are readily quantified and can be used to assess development and progression of the syndrome. Nutraceuticals, bioactive compounds derived from natural sources such as plants, fruits, cultures and grains, have a potential role in protection against cardiometabolic diseases. Relevant actions of nutraceuticals include their antioxidant, probiotic, anti-inflammatory, insulin-sensitising, lipid-modifying, anti-adiposity, and endothelial protective functions. This review explores the evidence for common nutrient deficiencies in metabolic syndrome alongside their role in preventing and modifying the complex elements that characterise this prevalent disease cluster.

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Cite

BibTeXRIS
BibTeX
@article{krentz2026nutraceuticals,
  title = {{Nutraceuticals and Metabolic Health: Can Supplements Prevent Metabolic Syndrome? A Narrative Review}},
  author = {Andrew J. Krentz and Oleksii Kozhevnikov and Jennifer E. McCallum and Lylah Drummond-Clarke and Megan Fant and Jing Han Ong and Sital Harris and Steven Walker},
  journal = {Nutrients},
  year = {2026},
  month = nov,
  doi = {10.3390/nu18213672},
  url = {https://www.mdpi.com/2072-6643/18/21/3672},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Nutraceuticals and Metabolic Health: Can Supplements Prevent Metabolic Syndrome? A Narrative Review
AU  - Andrew J. Krentz
AU  - Oleksii Kozhevnikov
AU  - Jennifer E. McCallum
AU  - Lylah Drummond-Clarke
AU  - Megan Fant
AU  - Jing Han Ong
AU  - Sital Harris
AU  - Steven Walker
PY  - 2026
DA  - 2026/11/05
JO  - Nutrients
DO  - 10.3390/nu18213672
UR  - https://www.mdpi.com/2072-6643/18/21/3672
AB  - Metabolic syndrome (MetS) encompasses a spectrum of disease pathologies that include dyslipidaemia, insulin resistance, hypertension, obesity, and inflammation. The rising prevalence of MetS and the associated morbidity and mortality represent a growing burden on global healthcare. MetS’s hallmarks are readily quantified and can be used to assess development and progression of the syndrome. Nutraceuticals, bioactive compounds derived from natural sources such as plants, fruits, cultures and grains, have a potential role in protection against cardiometabolic diseases. Relevant actions of nutraceuticals include their antioxidant, probiotic, anti-inflammatory, insulin-sensitising, lipid-modifying, anti-adiposity, and endothelial protective functions. This review explores the evidence for common nutrient deficiencies in metabolic syndrome alongside their role in preventing and modifying the complex elements that characterise this prevalent disease cluster.
SN  - 2072-6643
ER  -