Acquired Pure Red Cell Aplasia Secondary to Indolent Mature T-cell Lymphoid Malignancy

Abstract

Pure red cell aplasia (PRCA) is a rare hematologic disorder characterized by a marked decrease in reticulocytes and erythroid cells. For a long time up until today, PRCA has been clinically divided into idiopathic, thymoma-associated, and T-large granular lymphocytic leukemia (T-LGLL)-associated acquired PRCA (aPRCA). We herein report the case of a 90-year-old woman diagnosed with aPRCA secondary to an indolent mature T-cell malignancy atypical for T-LGLL. No apparent large granular lymphocytes were detected, tests for cytotoxic antigens, including granzyme B and perforin, were negative, and no STAT3 mutations were detected. Therefore, a careful evaluation of the underlying disease accompanied by aPRCA is required.

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BibTeX RIS

BibTeX

@article{motohashi2026acquired,
  title = {{Acquired Pure Red Cell Aplasia Secondary to Indolent Mature T-cell Lymphoid Malignancy}},
  author = {Saya Motohashi and Kenichi Ito and Kazuhiko Hirano and Naohiro Sekiguchi},
  journal = {Internal Medicine},
  year = {2026},
  month = sep,
  doi = {10.2169/internalmedicine.7852-26},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7852-26/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Acquired Pure Red Cell Aplasia Secondary to Indolent Mature T-cell Lymphoid Malignancy
AU  - Saya Motohashi
AU  - Kenichi Ito
AU  - Kazuhiko Hirano
AU  - Naohiro Sekiguchi
PY  - 2026
DA  - 2026/09/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.7852-26
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_7852-26/_article
AB  - Pure red cell aplasia (PRCA) is a rare hematologic disorder characterized by a marked decrease in reticulocytes and erythroid cells. For a long time up until today, PRCA has been clinically divided into idiopathic, thymoma-associated, and T-large granular lymphocytic leukemia (T-LGLL)-associated acquired PRCA (aPRCA). We herein report the case of a 90-year-old woman diagnosed with aPRCA secondary to an indolent mature T-cell malignancy atypical for T-LGLL. No apparent large granular lymphocytes were detected, tests for cytotoxic antigens, including granzyme B and perforin, were negative, and no STAT3 mutations were detected. Therefore, a careful evaluation of the underlying disease accompanied by aPRCA is required.
SN  - 1349-7235
SN  - 0918-2918
ER  -

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