Warm Autoimmune Hemolytic Anemia Associated with Pancreatic Adenocarcinoma Showing Ectopic Expression of Band…

Abstract

Autoimmune hemolytic anemia (AIHA) is rare in solid tumors and may represent a paraneoplastic phenomenon. We describe the case of a 73-year-old woman with unresectable pancreatic adenocarcinoma who developed steroid-refractory warm AIHA. Prednisolone partially improved her anemia but not her hemolysis. Chemotherapy with modified FOLFIRINOX followed by gemcitabine plus nab-paclitaxel improved both the tumor and anemia, enabling steroid tapering. Conversion surgery revealed the ectopic expression of band 3 in tumor cells. This case suggests that anti-band 3 antibodies may mediate paraneoplastic AIHA and emphasizes the importance of tumor control in steroid-refractory cases.

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BibTeX RIS

BibTeX

@article{goto2026warm,
  title = {{Warm Autoimmune Hemolytic Anemia Associated with Pancreatic Adenocarcinoma Showing Ectopic Expression of Band 3 Protein: A Case Report}},
  author = {Akari Goto and Makoto Yoshida and Ryosei Murai and Hiroto Horiguchi and Satoshi Iyama and Kazuma Ishikawa and Satoshi Takahashi and Kohichi Takada and Masayoshi Kobune},
  journal = {Internal Medicine},
  year = {2026},
  month = sep,
  doi = {10.2169/internalmedicine.6765-25},
  url = {https://www.jstage.jst.go.jp/article/internalmedicine/65/18/65_6765-25/_article},
  note = {CC BY-NC-ND},
}

RIS

TY  - JOUR
TI  - Warm Autoimmune Hemolytic Anemia Associated with Pancreatic Adenocarcinoma Showing Ectopic Expression of Band 3 Protein: A Case Report
AU  - Akari Goto
AU  - Makoto Yoshida
AU  - Ryosei Murai
AU  - Hiroto Horiguchi
AU  - Satoshi Iyama
AU  - Kazuma Ishikawa
AU  - Satoshi Takahashi
AU  - Kohichi Takada
AU  - Masayoshi Kobune
PY  - 2026
DA  - 2026/09/15
JO  - Internal Medicine
DO  - 10.2169/internalmedicine.6765-25
UR  - https://www.jstage.jst.go.jp/article/internalmedicine/65/18/65_6765-25/_article
AB  - Autoimmune hemolytic anemia (AIHA) is rare in solid tumors and may represent a paraneoplastic phenomenon. We describe the case of a 73-year-old woman with unresectable pancreatic adenocarcinoma who developed steroid-refractory warm AIHA. Prednisolone partially improved her anemia but not her hemolysis. Chemotherapy with modified FOLFIRINOX followed by gemcitabine plus nab-paclitaxel improved both the tumor and anemia, enabling steroid tapering. Conversion surgery revealed the ectopic expression of band 3 in tumor cells. This case suggests that anti-band 3 antibodies may mediate paraneoplastic AIHA and emphasizes the importance of tumor control in steroid-refractory cases.
SN  - 1349-7235
SN  - 0918-2918
ER  -

Abstract

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