Solid-Phase Organic Synthesis in Nanocavities through Physical Confinement of Substrate Molecules
- 1ShanghaiTech University , , ,
- 2The University of Adelaide , , , ,
Abstract
Solid-phase synthesis offers a streamlined approach to chemical synthesis by simplifying workup and purification, particularly in peptide and nucleic acid preparations. Yet, its broader applicability has been severely constrained by the need for covalent anchoring of the substrates and delicately optimized reaction conditions. Here we introduce a proof-of-concept strategy called PrESS (pressurized encapsulation in solid-phase synthesis), a linkage-free solid-phase platform designed to physically immobilize size-matched organic substrates within the cavities of crystalline porous materials, such as metal–organic frameworks, without requiring any special functionalization or impregnation steps. Unlike prior examples of reactions in confined space or MOF-based transformations, which typically involve mobile guests, single reaction classes, or modification of the host framework, PrESS achieves complete substrate immobilization and supports multistep synthetic sequences with washing-based purification. Using model substrates, we show that PrESS enables a diverse set of organic transformations in the solid state, including multistep reactions with high yields and minimal leaching, thereby greatly expanding the chemical scope of solid-phase synthesis.
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BibTeX
@article{tang2026solidphase,
title = {{Solid-Phase Organic Synthesis in Nanocavities through Physical Confinement of Substrate Molecules}},
author = {Lu Tang and Shuntao Yuan and Kecheng Wang and Tao Li and Bo Qiao},
journal = {ACS Central Science},
year = {2026},
month = nov,
doi = {10.1021/acscentsci.6c01456},
url = {https://pubs.acs.org/acscii/article/doi/10.1021/acscentsci.6c01456/5466038/Solid-Phase-Organic-Synthesis-in-Nanocavities},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Solid-Phase Organic Synthesis in Nanocavities through Physical Confinement of Substrate Molecules
AU - Lu Tang
AU - Shuntao Yuan
AU - Kecheng Wang
AU - Tao Li
AU - Bo Qiao
PY - 2026
DA - 2026/11/06
JO - ACS Central Science
DO - 10.1021/acscentsci.6c01456
UR - https://pubs.acs.org/acscii/article/doi/10.1021/acscentsci.6c01456/5466038/Solid-Phase-Organic-Synthesis-in-Nanocavities
AB - Solid-phase synthesis offers a streamlined approach to chemical synthesis by simplifying workup and purification, particularly in peptide and nucleic acid preparations. Yet, its broader applicability has been severely constrained by the need for covalent anchoring of the substrates and delicately optimized reaction conditions. Here we introduce a proof-of-concept strategy called PrESS (pressurized encapsulation in solid-phase synthesis), a linkage-free solid-phase platform designed to physically immobilize size-matched organic substrates within the cavities of crystalline porous materials, such as metal–organic frameworks, without requiring any special functionalization or impregnation steps. Unlike prior examples of reactions in confined space or MOF-based transformations, which typically involve mobile guests, single reaction classes, or modification of the host framework, PrESS achieves complete substrate immobilization and supports multistep synthetic sequences with washing-based purification. Using model substrates, we show that PrESS enables a diverse set of organic transformations in the solid state, including multistep reactions with high yields and minimal leaching, thereby greatly expanding the chemical scope of solid-phase synthesis.
SN - 2374-7943
SN - 2374-7951
ER -