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PreprintCC BYbioRxiv

Neuron types and distribution of a Drosophila driver line collection

  • L. Mais1
  • C. Managan
  • B. Yarbrough
  • G. P. Hopkins
  • J. R. Salinas
  • S. A. Lauchie
  • P. Hirsch
  • C. Karg
  • S. Saalfeld
  • W. Korff
  • G. Ihrke
  • D. Kainmueller
1 more authors
  • G. W. Meissner
  1. 1Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC)
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Abstract

Cell type designations label uniquely-identifiable groups of related cells that typically function in similar ways. Cell types divide the Drosophila melanogaster central nervous system into functional units, but remain challenging to target and identify. Previously we generated a driver line and image resource for targeting many neuron types (Meissner et al., 2025). Here we improve on identifying the targeted neurons by automated searching against electron microscopy datasets and manual scoring of search results to add 6,368 annotations across 1,772 driver lines in the collection. These annotations provide a potential training resource for future search algorithms. We then estimate the number of cell types and thus the fraction of the central nervous system labeled by the collection as a whole.

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Cite

BibTeXRIS
BibTeX
@misc{mais2026neuron,
  title = {{Neuron types and distribution of a Drosophila driver line collection}},
  author = {L. Mais and C. Managan and B. Yarbrough and G. P. Hopkins and J. R. Salinas and S. A. Lauchie and P. Hirsch and C. Karg and S. Saalfeld and W. Korff and G. Ihrke and D. Kainmueller and G. W. Meissner},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.06.756975},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.06.756975v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - Neuron types and distribution of a Drosophila driver line collection
AU  - L. Mais
AU  - C. Managan
AU  - B. Yarbrough
AU  - G. P. Hopkins
AU  - J. R. Salinas
AU  - S. A. Lauchie
AU  - P. Hirsch
AU  - C. Karg
AU  - S. Saalfeld
AU  - W. Korff
AU  - G. Ihrke
AU  - D. Kainmueller
AU  - G. W. Meissner
PY  - 2026
DA  - 2026/10/06
PB  - bioRxiv
DO  - 10.64898/2026.10.06.756975
UR  - https://www.biorxiv.org/content/10.64898/2026.10.06.756975v1
AB  - Cell type designations label uniquely-identifiable groups of related cells that typically function in similar ways. Cell types divide the Drosophila melanogaster central nervous system into functional units, but remain challenging to target and identify. Previously we generated a driver line and image resource for targeting many neuron types (Meissner et al., 2025). Here we improve on identifying the targeted neurons by automated searching against electron microscopy datasets and manual scoring of search results to add 6,368 annotations across 1,772 driver lines in the collection. These annotations provide a potential training resource for future search algorithms. We then estimate the number of cell types and thus the fraction of the central nervous system labeled by the collection as a whole.
ER  -