Skip to content
DraconiticResearch
Search Sources API
181,713 studies31 sourcesUpdated 40 min ago
Peer-reviewedCC BY-NC-NDCell Reports

Elevated phagocytic capacity directs innate spinal cord repair

  • Dana Klatt Shaw1,2,3
  • Vishnu Muraleedharan Saraswathy4,1,2,3
  • Anthony R. McAdow4,1,2,3
  • Lili Zhou4,1,2,3
  • Dongkook Park5,1,2
  • Ridim Dadasaheb Mote4,1,2,3
  • Amulya Saini4,1,2
  • Ashley J. Douthitt6,1,2,3
  • Katerina Stepankova6
  • Brittney Unverzagt7
  • Cédric G. Geoffroy6
  • Aaron N. Johnson5
1 more authors
  • Mayssa H. Mokalled8
8 affiliations
  1. 1Center of Regenerative Medicine Washington University School of Medicine, St. Louis, MO, USA 6110
  2. 2Department of Developmental Biology Washington University School of Medicine, St. Louis, MO, USA 630
  3. 3Hope Center for Neurological Disorders Washington University School of Medicine, St. Louis, MO, USA 63110
  4. 4Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
  5. 5Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
  6. 6Department of Neuroscience and Experimental Therapeutics, College of Medicine, Texas A&M Health Science Center, Houston, TX 77030, USA
  7. 7Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA; Center for Stem Cells and Regenerative Medicine, University of Notre Dame, Notre Dame, IN 46556, USA
  8. 8Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110, USA; Hope Center for Neurological Disorders, Washington University School of Medicine, St. Louis, MO 63110, USA; Center of Regenerative Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: [email protected]
Open at sourceDOICite

Abstract

Immune cells elicit a continuum of transcriptional states after spinal cord injury (SCI). In mammals, inefficient debris clearance and chronic inflammation impede recovery and overshadow pro-regenerative immune functions. We found that zebrafish SCI elicits transient immune activation and efficient debris clearance. Transcriptomics and genetic ablation showed zebrafish macrophages are highly phagocytic and required for regeneration. Comparisons between zebrafish and mammalian macrophages identified transcription and immune response regulator (tcim) as an immune-enriched regenerative gene. Deletion of zebrafish tcim impairs phagocytosis and regeneration and activates a pro-inflammatory signature in leukocytes. Tcim expression in zebrafish and mouse macrophages establishes its conserved roles by promoting lipid metabolism and the reprogramming of myeloid precursors into activated phagocytes. This study underscores a requirement for elevated phagocytic capacity to achieve innate spinal cord repair and identifies a gene with conserved function in mammalian cells.

Related

  1. Dual-targeted nanoparticles enable the ex vivo generation of cytotoxic and phagocytic CAR effector cells
    J. Hong, J. Lim, M. Park +8
    bioRxivPreprintCC BY-NC-NDFull textOncologybioRxiv
  2. TSPO-PET binding in vivo reflects increased phagocytic microglia at post mortem in people with frontotemporal dementia.
    Davi S Vontobel, Kei Onn Lai, Mehtap Bacioglu +17
    Acta neuropathologicaPeer-reviewedCC BYFull textNeurologyEurope PMC
  3. ApoE lipidation state directs immunometabolic reprogramming of human microglia
    Tsion G. Shiferaw, Snigdha Sarkar, Katelyn M. Baker +12
    Alzheimer's & dementia : the journal of the Alzheimer's AssociationPeer-reviewedCC BY-NC-NDFull textGeneral medicineEurope PMC
  4. LncRNA Gas5 directs SUV39H2 to establish heterochromatin and maintain genome stability
    Juntao Liu, Jiani Yang, Wen Ye +6
    Protein & CellPeer-reviewedCC BY 4.0Full textOncologyPMC
  5. An Epstein-Barr virus-encoded snoRNA directs 2′-O-methylation of human rRNAs to control translation and the viral lytic switch
    Yarden Dan, Beáta E Jády, Yudit Halperin +8
    Cell ReportsPeer-reviewedCC BY-NC-ND 4.0Full text1 citedMicrobiologyInfectious diseaseHAL

Cite

BibTeXRIS
BibTeX
@article{shaw2026elevated,
  title = {{Elevated phagocytic capacity directs innate spinal cord repair}},
  author = {Dana Klatt Shaw and Vishnu Muraleedharan Saraswathy and Anthony R. McAdow and Lili Zhou and Dongkook Park and Ridim Dadasaheb Mote and Amulya Saini and Ashley J. Douthitt and Katerina Stepankova and Brittney Unverzagt and Cédric G. Geoffroy and Aaron N. Johnson and Mayssa H. Mokalled},
  journal = {Cell Reports},
  year = {2026},
  month = jun,
  doi = {10.1016/j.celrep.2026.117482},
  url = {https://doi.org/10.1016/j.celrep.2026.117482},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Elevated phagocytic capacity directs innate spinal cord repair
AU  - Dana Klatt Shaw
AU  - Vishnu Muraleedharan Saraswathy
AU  - Anthony R. McAdow
AU  - Lili Zhou
AU  - Dongkook Park
AU  - Ridim Dadasaheb Mote
AU  - Amulya Saini
AU  - Ashley J. Douthitt
AU  - Katerina Stepankova
AU  - Brittney Unverzagt
AU  - Cédric G. Geoffroy
AU  - Aaron N. Johnson
AU  - Mayssa H. Mokalled
PY  - 2026
DA  - 2026/06/01
JO  - Cell Reports
DO  - 10.1016/j.celrep.2026.117482
UR  - https://doi.org/10.1016/j.celrep.2026.117482
AB  - Immune cells elicit a continuum of transcriptional states after spinal cord injury (SCI). In mammals, inefficient debris clearance and chronic inflammation impede recovery and overshadow pro-regenerative immune functions. We found that zebrafish SCI elicits transient immune activation and efficient debris clearance. Transcriptomics and genetic ablation showed zebrafish macrophages are highly phagocytic and required for regeneration. Comparisons between zebrafish and mammalian macrophages identified transcription and immune response regulator (tcim) as an immune-enriched regenerative gene. Deletion of zebrafish tcim impairs phagocytosis and regeneration and activates a pro-inflammatory signature in leukocytes. Tcim expression in zebrafish and mouse macrophages establishes its conserved roles by promoting lipid metabolism and the reprogramming of myeloid precursors into activated phagocytes. This study underscores a requirement for elevated phagocytic capacity to achieve innate spinal cord repair and identifies a gene with conserved function in mammalian cells.
SN  - 2211-1247
SN  - 2639-1856
ER  -