Predictive value of CT perfusion imaging parameters and PI3K/Akt/mTOR signaling pathway related genes for EGFR gene mutations in lung adenocarcinoma patients
- 1Department of Radiology,Southern Branch of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao TongUniversity School of Medicine,Shanghai 201400,China
Abstract
Objective To explore the relationship between epidermal growth factor receptor(EGFR)gene mutations and histopathology in patients with lung adenocarcinoma(LUAD),as well as the predictive value of computed tomography(CT)perfusion imaging parameters and genes related to phosphatidylinositol 3 - kinase(PI3K)/serine/threonine protein kinase(Akt)/rapamycin target protein(mTOR)signaling pathways for EGFR gene mutations. Methods A total of 385 patients with LUAD admitted to the Southern Branch of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2022 to August 2025 were selected as study subjects. Next-generation sequencing(NGS)was performed,and they were divided into a positive group(227 cases)and a negative group(158 cases)based on the presence or absence of EGFR mutations. The clinical data,histopathological conditions,CT perfusion imaging parameters,and PI3K/Akt/mTOR signaling pathway related genes of two groups were compared,and the risk factors for EGFR gene mutations in LUAD patients were analyzed by multivariate logistic regression analysis.The predictive value of CT perfusion imaging parameters and PI3K/Akt/mTOR signaling pathway related genes for EGFR gene mutations in LUAD patients was analyzed by receiver operating characteristic(ROC)curves. Results The proportion of patients with age ≤65 years old,papillary type,PI3K catalytic subunit α(PIK3CA)positive,PI3K catalytic subunit β(PIK3CB)positive,and PI3K catalytic subunit γ(PIK3CG)positive in the positive group were 67.40%,51.10%,60.79%,38.33%,and 62.11%,respectively,which were higher than the negative group's 46.84%,37.34%,29.11%,28.48%,and 39.24%(P<0.05). The positive group had higher blood volume(BV)and longer time to peak(TTP)compared to the negative group(P<0.05). The results of multivariate logistic regression analysis showed that age ≤65 years,papillary type,PIK3CA positive,PIK3CG positive,high BV,and long TTP were independent predictors for EGFR gene mutations in LUAD patients(OR=2.408,2.776,2.465,1.966,2.492,7.561,P<0.05). The area under the curve(AUC)of PIK3CA,PIK3CG,BV,TTP,and combined examination for predicting EGFR gene mutations in LUAD patients were 0.658,0.650,0.653,0.658,and 0.828,respectively. The predicting sensitivities were 60.79%,69.16%,60.35%,62.56%,and 84.14%,respectively,and the specificities were 70.89%,60.76%,67.72% ,65.82% ,and 70.25% ,respectively,with the combined detection showing the highest AUC(P<0.05).Conclusion Age ≤65 years,papillary type,PIK3CA positive,PIK3CG positive,high BV,and long TTP are related factors for EGFR gene mutations in LUAD patients. The combined examination of PIK3CA,PIK3CG,BV,and TTP has the highest predictive value for EGFR gene mutations in LUAD patients.
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BibTeX
@article{miaomiao2026predictive,
title = {{Predictive value of CT perfusion imaging parameters and PI3K/Akt/mTOR signaling pathway related genes for EGFR gene mutations in lung adenocarcinoma patients}},
author = {TIAN Miaomiao and PAN Haibin and LI Xiaobing and GU Chunrong and YU Dongye},
journal = {Zhongguo linchuang yanjiu},
year = {2026},
month = oct,
doi = {10.13429/j.cnki.cjcr.2026.10.003},
url = {https://doi.org/10.13429/j.cnki.cjcr.2026.10.003},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Predictive value of CT perfusion imaging parameters and PI3K/Akt/mTOR signaling pathway related genes for EGFR gene mutations in lung adenocarcinoma patients
AU - TIAN Miaomiao
AU - PAN Haibin
AU - LI Xiaobing
AU - GU Chunrong
AU - YU Dongye
PY - 2026
DA - 2026/10/26
JO - Zhongguo linchuang yanjiu
DO - 10.13429/j.cnki.cjcr.2026.10.003
UR - https://doi.org/10.13429/j.cnki.cjcr.2026.10.003
AB - Objective To explore the relationship between epidermal growth factor receptor(EGFR)gene mutations and histopathology in patients with lung adenocarcinoma(LUAD),as well as the predictive value of computed tomography(CT)perfusion imaging parameters and genes related to phosphatidylinositol 3 - kinase(PI3K)/serine/threonine protein kinase(Akt)/rapamycin target protein(mTOR)signaling pathways for EGFR gene mutations. Methods A total of 385 patients with LUAD admitted to the Southern Branch of Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine from January 2022 to August 2025 were selected as study subjects. Next-generation sequencing(NGS)was performed,and they were divided into a positive group(227 cases)and a negative group(158 cases)based on the presence or absence of EGFR mutations. The clinical data,histopathological conditions,CT perfusion imaging parameters,and PI3K/Akt/mTOR signaling pathway related genes of two groups were compared,and the risk factors for EGFR gene mutations in LUAD patients were analyzed by multivariate logistic regression analysis.The predictive value of CT perfusion imaging parameters and PI3K/Akt/mTOR signaling pathway related genes for EGFR gene mutations in LUAD patients was analyzed by receiver operating characteristic(ROC)curves. Results The proportion of patients with age ≤65 years old,papillary type,PI3K catalytic subunit α(PIK3CA)positive,PI3K catalytic subunit β(PIK3CB)positive,and PI3K catalytic subunit γ(PIK3CG)positive in the positive group were 67.40%,51.10%,60.79%,38.33%,and 62.11%,respectively,which were higher than the negative group's 46.84%,37.34%,29.11%,28.48%,and 39.24%(P<0.05). The positive group had higher blood volume(BV)and longer time to peak(TTP)compared to the negative group(P<0.05). The results of multivariate logistic regression analysis showed that age ≤65 years,papillary type,PIK3CA positive,PIK3CG positive,high BV,and long TTP were independent predictors for EGFR gene mutations in LUAD patients(OR=2.408,2.776,2.465,1.966,2.492,7.561,P<0.05). The area under the curve(AUC)of PIK3CA,PIK3CG,BV,TTP,and combined examination for predicting EGFR gene mutations in LUAD patients were 0.658,0.650,0.653,0.658,and 0.828,respectively. The predicting sensitivities were 60.79%,69.16%,60.35%,62.56%,and 84.14%,respectively,and the specificities were 70.89%,60.76%,67.72% ,65.82% ,and 70.25% ,respectively,with the combined detection showing the highest AUC(P<0.05).Conclusion Age ≤65 years,papillary type,PIK3CA positive,PIK3CG positive,high BV,and long TTP are related factors for EGFR gene mutations in LUAD patients. The combined examination of PIK3CA,PIK3CG,BV,and TTP has the highest predictive value for EGFR gene mutations in LUAD patients.
SN - 1674-8182
ER -