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Peer-reviewedCC BYNeuroscience and biobehavioral reviews

Updated models of adolescent substance-related interference and problems (A-SIP) and measurement via the Substance-related Interference and Problems Identification Test (SIP-IT)

  • Genevieve F. Dash1,2
  • Kristine Rømer Thomsen2
  • Elisa M. Trucco3
  • Emese Kroon4
  • Janna Cousijn4
  • Adam M. Leventhal5
  • Sarah W. Feldstein Ewing1
5 affiliations
  1. 1Department of Psychiatry, UConn School of Medicine, Farmington, CT, USA
  2. 2Department of Psychology and Behavioral Sciences, Center for Alcohol and Drug Research, Aarhus University, Aarhus C, Denmark
  3. 3Department of Psychology, Florida International University, Miami, FL, USA
  4. 4Department of Psychology, Education, and Child Studies, Erasmus University Rotterdam, Rotterdam, Netherlands
  5. 5Institute for Addiction Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
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Abstract

The inherent developmental distinctions in brain structure, connectivity, and function between adolescents and adults continue to gain recognition. However, these neurodevelopmental considerations have yet to translate into real-world, practical modifications to etiological models, diagnostic systems, and assessments used by clinicians and practitioners working with adolescents engaged in substance use. This review leverages over 15 years of human translational (integrated adolescent brain and clinical intervention) research to evaluate current models of addiction, substance use disorder criteria, and their developmental synchrony with the adolescent age group. Consonant with increasing calls for an age-appropriate conceptualization of substance-related problems, this review offers a novel and developmentally-tailored definition of substance-related problems, termed Adolescent Substance-related Interference and Problems (A-SIP), capturing ten developmentally-informed symptoms across three functional domains: occupational, social/peer, and family/guardian(s). We also provide the accompanying tool, measurement of Substance-related Interference and Problems Identification Test (SIP-IT), for on-the-ground practitioners to more accurately identify A-SIP in adolescents.

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Cite

BibTeXRIS
BibTeX
@article{dash2026updated,
  title = {{Updated models of adolescent substance-related interference and problems (A-SIP) and measurement via the Substance-related Interference and Problems Identification Test (SIP-IT)}},
  author = {Genevieve F. Dash and Kristine Rømer Thomsen and Elisa M. Trucco and Emese Kroon and Janna Cousijn and Adam M. Leventhal and Sarah W. Feldstein Ewing},
  journal = {Neuroscience and biobehavioral reviews},
  year = {2026},
  month = aug,
  doi = {10.1016/j.neubiorev.2026.106898},
  url = {https://doi.org/10.1016/j.neubiorev.2026.106898},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Updated models of adolescent substance-related interference and problems (A-SIP) and measurement via the Substance-related Interference and Problems Identification Test (SIP-IT)
AU  - Genevieve F. Dash
AU  - Kristine Rømer Thomsen
AU  - Elisa M. Trucco
AU  - Emese Kroon
AU  - Janna Cousijn
AU  - Adam M. Leventhal
AU  - Sarah W. Feldstein Ewing
PY  - 2026
DA  - 2026/08/11
JO  - Neuroscience and biobehavioral reviews
DO  - 10.1016/j.neubiorev.2026.106898
UR  - https://doi.org/10.1016/j.neubiorev.2026.106898
AB  - The inherent developmental distinctions in brain structure, connectivity, and function between adolescents and adults continue to gain recognition. However, these neurodevelopmental considerations have yet to translate into real-world, practical modifications to etiological models, diagnostic systems, and assessments used by clinicians and practitioners working with adolescents engaged in substance use. This review leverages over 15 years of human translational (integrated adolescent brain and clinical intervention) research to evaluate current models of addiction, substance use disorder criteria, and their developmental synchrony with the adolescent age group. Consonant with increasing calls for an age-appropriate conceptualization of substance-related problems, this review offers a novel and developmentally-tailored definition of substance-related problems, termed Adolescent Substance-related Interference and Problems (A-SIP), capturing ten developmentally-informed symptoms across three functional domains: occupational, social/peer, and family/guardian(s). We also provide the accompanying tool, measurement of Substance-related Interference and Problems Identification Test (SIP-IT), for on-the-ground practitioners to more accurately identify A-SIP in adolescents.
SN  - 0149-7634
SN  - 1873-7528
ER  -