Prevalence of Factor V Leiden mutation in yemeni women with gestational diabetes mellitus and recurrent pregnancy loss: a case-control study.
- 1Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen.
- 2Department of Biochemistry and Molecular Biology, Faculty of Medicine and Health Sciences, Sana'a University, Sana'a, Yemen. [email protected].
Abstract
Background
Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders during pregnancy and has been associated with recurrent pregnancy loss (RPL) and other obstetric complications. The Factor V Leiden (FVL) is a common inherited thrombophilic mutation. However, data on the prevalence of the FVL mutation among Yemeni women with GDM and a history of RPL remain scarce. Therefore, this case-control study aimed to determine the prevalence of the FVL mutation and examine its association among Yemeni women with GDM and recurrent pregnancy loss compared with healthy pregnant controls.Methods
This case-control study included 200 Yemeni women with GDM and 200 healthy pregnant controls without a previous history of GDM. Ethical approval was obtained from the Research Ethics Committee of the Faculty of Medicine and Health Sciences, Sana'a University. The GDM group consisted of women with a history of adverse pregnancy outcomes, including spontaneous abortion and/or stillbirth. The FVL (G1691A) mutation was detected by real-time PCR using genomic DNA extracted from peripheral blood leukocytes (white blood cells). Statistical analyses were performed using SPSS version 22.Results
Allelic frequencies for FVL were 0.93 (G) and 0.07 (A) in the GDM group, compared to 0.98 (G) and 0.02 (A) in controls. The FVL mutation was more common among women with GDM and recurrent pregnancy loss. Clinical findings in the GDM group showed significantly higher PT, APTT, fasting blood glucose, blood pressure, HbA1c, and lipid profile values than healthy controls. Differences in FVL mutation incidence and clinical measures between the GDM and control groups were statistically significant.Conclusion
Our study found a higher prevalence of the Factor V Leiden (FVL) mutation among Yemeni women with gestational diabetes mellitus (GDM) and a history of recurrent pregnancy loss (RPL) than among healthy pregnant controls. The observed association suggests that the FVL mutation may contribute to the clinical profile of this group. However, further large-scale prospective studies with appropriate comparison groups are needed to validate these findings and to clarify whether FVL screening could have a meaningful role in the clinical management of pregnancies.
Related
- Pregnancy Complicated by Citrin Deficiency and Gestational Diabetes Mellitus: Perioperative Metabolic Management and Postoperative Analgesic Challenges Following Caesarean Delivery
- Preconceptional Risk Factors Associated With Gestational Diabetes Mellitus and Pregnancy Outcomes: A Case-Control Study
- Maternity versus non‐maternity healthcare settings for the diagnosis of gestational diabetes or diabetes in pregnancy
- Associations of pre-pregnancy BMI and gestational weight gain with large-for-gestational-age in women with gestational diabetes mellitus in Southwestern China.
- Underweight at age 20 and pre‐pregnancy and large‐for‐gestational‐age births in Japanese women with gestational diabetes mellitus: Hamamatsu GRACE Study 4
BibTeX
@article{matari2026prevalence,
title = {{Prevalence of Factor V Leiden mutation in yemeni women with gestational diabetes mellitus and recurrent pregnancy loss: a case-control study.}},
author = {Nabeela A Al Matari and Abdulkarim M Al-Obeidi and Ebtesam Al-Zabedi},
journal = {BMC medical genomics},
year = {2026},
month = jul,
doi = {10.1186/s12920-026-02429-z},
url = {https://europepmc.org/article/MED/42958338},
note = {CC BY},
}
RIS
TY - JOUR
TI - Prevalence of Factor V Leiden mutation in yemeni women with gestational diabetes mellitus and recurrent pregnancy loss: a case-control study.
AU - Nabeela A Al Matari
AU - Abdulkarim M Al-Obeidi
AU - Ebtesam Al-Zabedi
PY - 2026
DA - 2026/07/31
JO - BMC medical genomics
DO - 10.1186/s12920-026-02429-z
UR - https://europepmc.org/article/MED/42958338
AB - Background Gestational diabetes mellitus (GDM) is one of the most common metabolic disorders during pregnancy and has been associated with recurrent pregnancy loss (RPL) and other obstetric complications. The Factor V Leiden (FVL) is a common inherited thrombophilic mutation. However, data on the prevalence of the FVL mutation among Yemeni women with GDM and a history of RPL remain scarce. Therefore, this case-control study aimed to determine the prevalence of the FVL mutation and examine its association among Yemeni women with GDM and recurrent pregnancy loss compared with healthy pregnant controls.Methods This case-control study included 200 Yemeni women with GDM and 200 healthy pregnant controls without a previous history of GDM. Ethical approval was obtained from the Research Ethics Committee of the Faculty of Medicine and Health Sciences, Sana'a University. The GDM group consisted of women with a history of adverse pregnancy outcomes, including spontaneous abortion and/or stillbirth. The FVL (G1691A) mutation was detected by real-time PCR using genomic DNA extracted from peripheral blood leukocytes (white blood cells). Statistical analyses were performed using SPSS version 22.Results Allelic frequencies for FVL were 0.93 (G) and 0.07 (A) in the GDM group, compared to 0.98 (G) and 0.02 (A) in controls. The FVL mutation was more common among women with GDM and recurrent pregnancy loss. Clinical findings in the GDM group showed significantly higher PT, APTT, fasting blood glucose, blood pressure, HbA1c, and lipid profile values than healthy controls. Differences in FVL mutation incidence and clinical measures between the GDM and control groups were statistically significant.Conclusion Our study found a higher prevalence of the Factor V Leiden (FVL) mutation among Yemeni women with gestational diabetes mellitus (GDM) and a history of recurrent pregnancy loss (RPL) than among healthy pregnant controls. The observed association suggests that the FVL mutation may contribute to the clinical profile of this group. However, further large-scale prospective studies with appropriate comparison groups are needed to validate these findings and to clarify whether FVL screening could have a meaningful role in the clinical management of pregnancies.
SN - 1755-8794
ER -