Deaths Mentioning Both Pancreatic Cancer and Renal Failure in the United States, 1999–2024: Temporal Trends and Disparities
7 affiliations
- 1Academic Unit of Gastroenterology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield S5 7AU, UK
- 2Department of General Medicine, CMH Multan Institute of Medical Sciences, Multan 6000, Pakistan
- 3Department of General Medicine, Barasat Government Medical College and Hospital, Barasat 700124, India
- 4Department of Hospital Medicine, Yale New Haven Hospital, New Haven, CT 06510, USA
- 5Division of Gastroenterology, Hepatology & Motility, The University of Kansas School of Medicine, Kansas City, KS 66160, USA
- 6School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Kharagpur 721302, India
- 7School of Medicine, University of Nottingham, Nottingham NG7 2UH, UK
Abstract
Background: We examined temporal trends in deaths mentioning both pancreatic cancer and renal failure in the United States. Methods: We analyzed CDC WONDER multiple-cause-of-death data for adults aged ≥25 years from 1999 to 2024. Age-adjusted mortality rates (AAMRs) were assessed using Joinpoint regression. Secondary analyses quantified renal-failure co-recording among pancreatic-cancer-involving deaths, renal-failure subtypes, disparities, and comparisons with lung and bronchus, colorectal, and liver and intrahepatic bile duct cancers. Results: Overall, 31,497 deaths mentioned both conditions. The AAMR increased from 0.37 per 100,000 in 1999 to 0.82 in 2024, with the most rapid increase during 2018–2024 (annual percentage change, 10.77%; 95% CI, 7.18–18.22%). Renal failure was co-recorded in 2.98% of pancreatic-cancer-involving deaths. Corresponding proportions were 2.37% for lung and bronchus, 4.75% for colorectal, and 5.77% for liver and intrahepatic bile duct cancer; recent trends did not differ significantly from pancreatic cancer. Acute kidney failure was the most frequently recorded renal subtype (43.22%). In 2024, AAMRs were higher among males and highest among non-Hispanic Black individuals. Conclusions: Renal-failure co-recording with pancreatic cancer increased markedly after 2018 but was not unique to pancreatic cancer. Death-certificate data do not establish temporal sequence or causality; linked clinical data are needed to clarify potentially modifiable kidney-related pathways.
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BibTeX
@article{dhali2026deaths,
title = {{Deaths Mentioning Both Pancreatic Cancer and Renal Failure in the United States, 1999–2024: Temporal Trends and Disparities}},
author = {Arkadeep Dhali and Ali Shan Hafeez and Jyotirmoy Biswas and Ashish Sharma and Dushyant Singh Dahiya and Rick Maity and Saikat Mandal},
journal = {Epidemiologia},
year = {2026},
month = sep,
doi = {10.3390/epidemiologia7050124},
url = {https://doi.org/10.3390/epidemiologia7050124},
note = {CC BY},
}
RIS
TY - JOUR
TI - Deaths Mentioning Both Pancreatic Cancer and Renal Failure in the United States, 1999–2024: Temporal Trends and Disparities
AU - Arkadeep Dhali
AU - Ali Shan Hafeez
AU - Jyotirmoy Biswas
AU - Ashish Sharma
AU - Dushyant Singh Dahiya
AU - Rick Maity
AU - Saikat Mandal
PY - 2026
DA - 2026/09/01
JO - Epidemiologia
DO - 10.3390/epidemiologia7050124
UR - https://doi.org/10.3390/epidemiologia7050124
AB - Background: We examined temporal trends in deaths mentioning both pancreatic cancer and renal failure in the United States. Methods: We analyzed CDC WONDER multiple-cause-of-death data for adults aged ≥25 years from 1999 to 2024. Age-adjusted mortality rates (AAMRs) were assessed using Joinpoint regression. Secondary analyses quantified renal-failure co-recording among pancreatic-cancer-involving deaths, renal-failure subtypes, disparities, and comparisons with lung and bronchus, colorectal, and liver and intrahepatic bile duct cancers. Results: Overall, 31,497 deaths mentioned both conditions. The AAMR increased from 0.37 per 100,000 in 1999 to 0.82 in 2024, with the most rapid increase during 2018–2024 (annual percentage change, 10.77%; 95% CI, 7.18–18.22%). Renal failure was co-recorded in 2.98% of pancreatic-cancer-involving deaths. Corresponding proportions were 2.37% for lung and bronchus, 4.75% for colorectal, and 5.77% for liver and intrahepatic bile duct cancer; recent trends did not differ significantly from pancreatic cancer. Acute kidney failure was the most frequently recorded renal subtype (43.22%). In 2024, AAMRs were higher among males and highest among non-Hispanic Black individuals. Conclusions: Renal-failure co-recording with pancreatic cancer increased markedly after 2018 but was not unique to pancreatic cancer. Death-certificate data do not establish temporal sequence or causality; linked clinical data are needed to clarify potentially modifiable kidney-related pathways.
SN - 2673-3986
ER -