Endoplasmic reticulum and Golgi stress signaling-mediated regulation of protein secretion
Abstract
The eukaryotic secretory pathway (SP) is essential to ensure cellular functions and multicellular communication. The early SP is constituted mostly of the endoplasmic reticulum (ER), the ER–Golgi intermediate compartment (ERGIC), and the Golgi apparatus. These intracellular organelles achieve proper folding and modification of newly synthesized transmembrane and secretory proteins, en route to their final destination, e.g., plasma membrane, endosomes, lysosomes, and the extracellular space. They also integrate quality control systems to ensure export of productively folded proteins and to trigger dysfunctional proteins to degradation. The ER as the first SP compartment is subjected to a precise control of its own homeostasis through signaling of the unfolded protein response. In this review, we provide an overview of the early SP and its regulatory mechanisms, focusing on the ER and Golgi stress-dependent signaling. We contextualize this information within physiological and pathological processes, and discuss how ER and Golgi stress responses might coordinate their regulatory effects across the entire SP.
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BibTeX
@article{bakambamba2026endoplasmic,
title = {{Endoplasmic reticulum and Golgi stress signaling-mediated regulation of protein secretion}},
author = {Ketsia Bakambamba and Manon Nivet and Sophie Martin and Elodie Lafont and Eric Chevet and Tony Avril},
journal = {Cellular and Molecular Biology Letters},
year = {2026},
month = oct,
doi = {10.1186/s11658-026-00932-w},
url = {https://hal.science/hal-05621160v1},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Endoplasmic reticulum and Golgi stress signaling-mediated regulation of protein secretion
AU - Ketsia Bakambamba
AU - Manon Nivet
AU - Sophie Martin
AU - Elodie Lafont
AU - Eric Chevet
AU - Tony Avril
PY - 2026
DA - 2026/10/13
JO - Cellular and Molecular Biology Letters
DO - 10.1186/s11658-026-00932-w
UR - https://hal.science/hal-05621160v1
AB - The eukaryotic secretory pathway (SP) is essential to ensure cellular functions and multicellular communication. The early SP is constituted mostly of the endoplasmic reticulum (ER), the ER–Golgi intermediate compartment (ERGIC), and the Golgi apparatus. These intracellular organelles achieve proper folding and modification of newly synthesized transmembrane and secretory proteins, en route to their final destination, e.g., plasma membrane, endosomes, lysosomes, and the extracellular space. They also integrate quality control systems to ensure export of productively folded proteins and to trigger dysfunctional proteins to degradation. The ER as the first SP compartment is subjected to a precise control of its own homeostasis through signaling of the unfolded protein response. In this review, we provide an overview of the early SP and its regulatory mechanisms, focusing on the ER and Golgi stress-dependent signaling. We contextualize this information within physiological and pathological processes, and discuss how ER and Golgi stress responses might coordinate their regulatory effects across the entire SP.
SN - 1425-8153
SN - 1689-1392
ER -