Skip to content
DraconiticResearch
Search Sources API
186,125 studies31 sourcesUpdated 4 min ago
Peer-reviewedCC BY 4.0PLOS One

Low diet quality increases the genetic risk of high blood cholesterol levels in Asian Indian adults [CURES – 165]

  • Manahil M. Bineid1
  • Dhanasekaran Bodhini2
  • Kandaswamy Ramya3
  • Coimbatore Subramanian Shanthi Rani4
  • Rajendra Pradeepa5
  • Ranjit Mohan Anjana6
  • Venkatesan Radha7
  • Viswanathan Mohan
  • Karani Santhanakrishnan Vimaleswaran
7 affiliations
  1. 1Hugh Sinclair Unit of Human Nutrition, Department of Food and Nutritional Sciences, Institute for Cardiovascular and Metabolic Research (ICMR), University of Reading, Reading, United Kingdom
  2. 2Department of Food and Nutritional Sciences, College of Agriculture and Food Sciences, King Faisal University, Al-Ahsa, Saudi Arabia
  3. 3Department of Molecular Genetics, Madras Diabetes Research Foundation, Chennai, India
  4. 4Department of Clinical Epidemiology, Madras Diabetes Research Foundation, Chennai, India
  5. 5Department of Research Operations and Diabetes Complications, Madras Diabetes Research Foundation, Chennai, India
  6. 6Department of Diabetology, Madras Diabetes Research Foundation (ICMR- Collaborating Centre of Excellence) & Dr Mohan’s Diabetes Specialities Centre (IDF Centre of Excellence in Diabetes Care), Chennai, India
  7. 7The Institute for Food, Nutrition and Health (IFNH), University of Reading, Reading, United Kingdom
Open at sourcePDFDOICite

Abstract

Background: Asian Indians face an increased burden of cardiometabolic diseases, yet the interplay between genetic predisposition and diet quality in this population remains underexplored. This study aimed to examine their interaction on cardiometabolic traits in this population. Methods: We conducted a cross-sectional analysis of 1,020 adults (452 men, 568 women; aged 25–80 years) from the Chennai Urban Rural Epidemiology Study (CURES). A genetic risk score (GRS) of three variants: TCF7L2 rs7903146, FTO rs8050136, and FTO rs1588413 was constructed. Diet quality was evaluated using the Indian Diet Quality Score, based on the intake of eight food groups. Associations between the GRS and cardiometabolic traits, as well as the interactions between the GRS and diet quality score, were assessed. Results: A high GRS was significantly associated with higher fasting plasma glucose (p = 0.005) and glycated haemoglobin (p = 0.006). Significant interactions between the GRS and the diet quality score were observed on total cholesterol (Pinteraction = 0.003) and low-density lipoprotein cholesterol (Pinteraction = 0.005) concentrations, after correction for multiple testing. At the low diet quality score level, individuals with a high GRS had significantly higher total cholesterol and low-density lipoprotein cholesterol concentrations than those with a low GRS (p < 0.001, for all comparisons). Conclusion: This study provides novel evidence for the effect of gene–diet quality interactions on lipid outcomes in Asian Indians. Individuals with higher genetic risk may be more vulnerable to lipid abnormalities when adhering to a low-quality diet, emphasising the value of integrating genetic and dietary data into personalised nutrition strategies for lipid-related cardiometabolic risk prevention.

Related

  1. Excessive cholesterol accumulation in microglia increases neuronal synaptic vulnerability to amyloid-beta
    S. Ding, N. Nazarenkov, J. Kim +3
    bioRxivPreprintCC BY-NDFull textNeurosciencebioRxiv
  2. Association of MALAT1 and TUG1 transcript levels and cardiometabolic diseases according to cholesterol saturated fat index
    Niloufar Rasaei, Mahsa Samadi, Farideh Shiraseb +8
    Scientific ReportsPeer-reviewedCC BY-NC-ND 4.0Full textGenetics & genomicsCrossref
  3. Interspecific introgression increases genetic diversity and reduces genetic load in red kites
    M. A. Chase, V. Peona, F. Lammers +24
    bioRxivPreprintCC BYFull textEvolutionary biologybioRxiv
  4. Genetic polymorphisms and hypertension in Indian populations: a systematic review and integrative bioinformatics approach
    Rooban Sivakumar, Prasath N, Lakshmi Vijukumar +3
    BMC Medical GenomicsPeer-reviewedCC BYFull textGenetics & genomicsDOAJ
  5. Colonisation history of a vector species of veterinary interest: phylogeography of Culicoides imicola (Diptera: Ceratopogonidae) in the Indian Ocean revealing low genetic structure
    Lorn Ribon-Chaudat, Karine Huber, David Bru +10
    ParasitePeer-reviewedCC BY 4.0Full textEcologyHAL

Cite

BibTeXRIS
BibTeX
@article{bineid2026diet,
  title = {{Low diet quality increases the genetic risk of high blood cholesterol levels in Asian Indian adults [CURES – 165]}},
  author = {Manahil M. Bineid and Dhanasekaran Bodhini and Kandaswamy Ramya and Coimbatore Subramanian Shanthi Rani and Rajendra Pradeepa and Ranjit Mohan Anjana and Venkatesan Radha and Viswanathan Mohan and Karani Santhanakrishnan Vimaleswaran},
  journal = {PLOS One},
  year = {2026},
  month = oct,
  doi = {10.1371/journal.pone.0357182},
  url = {https://doi.org/10.1371/journal.pone.0357182},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Low diet quality increases the genetic risk of high blood cholesterol levels in Asian Indian adults [CURES – 165]
AU  - Manahil M. Bineid
AU  - Dhanasekaran Bodhini
AU  - Kandaswamy Ramya
AU  - Coimbatore Subramanian Shanthi Rani
AU  - Rajendra Pradeepa
AU  - Ranjit Mohan Anjana
AU  - Venkatesan Radha
AU  - Viswanathan Mohan
AU  - Karani Santhanakrishnan Vimaleswaran
PY  - 2026
DA  - 2026/10/14
JO  - PLOS One
DO  - 10.1371/journal.pone.0357182
UR  - https://doi.org/10.1371/journal.pone.0357182
AB  - Background: Asian Indians face an increased burden of cardiometabolic diseases, yet the interplay between genetic predisposition and diet quality in this population remains underexplored. This study aimed to examine their interaction on cardiometabolic traits in this population. Methods: We conducted a cross-sectional analysis of 1,020 adults (452 men, 568 women; aged 25–80 years) from the Chennai Urban Rural Epidemiology Study (CURES). A genetic risk score (GRS) of three variants: TCF7L2 rs7903146, FTO rs8050136, and FTO rs1588413 was constructed. Diet quality was evaluated using the Indian Diet Quality Score, based on the intake of eight food groups. Associations between the GRS and cardiometabolic traits, as well as the interactions between the GRS and diet quality score, were assessed. Results: A high GRS was significantly associated with higher fasting plasma glucose (p = 0.005) and glycated haemoglobin (p = 0.006). Significant interactions between the GRS and the diet quality score were observed on total cholesterol (Pinteraction = 0.003) and low-density lipoprotein cholesterol (Pinteraction = 0.005) concentrations, after correction for multiple testing. At the low diet quality score level, individuals with a high GRS had significantly higher total cholesterol and low-density lipoprotein cholesterol concentrations than those with a low GRS (p < 0.001, for all comparisons). Conclusion: This study provides novel evidence for the effect of gene–diet quality interactions on lipid outcomes in Asian Indians. Individuals with higher genetic risk may be more vulnerable to lipid abnormalities when adhering to a low-quality diet, emphasising the value of integrating genetic and dietary data into personalised nutrition strategies for lipid-related cardiometabolic risk prevention.
SN  - 1932-6203
ER  -