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Peer-reviewedCC BYMedicine

Bibliometric analysis of key biomarkers in sepsis-induced coagulopathy (2006–2025)

  • Yidan Zhao1
  • Huaxing Yao2
  • Dong Lai3
  • Pingping Xiao4
  • Amei Li1
4 affiliations
  1. 1Department of Critical Care Medicine I, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian, China
  2. 2Department of Pharmacy, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian, China
  3. 3Department of Blood Transfusion, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian, China
  4. 4Department of Hematology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen, Fujian, China.
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Abstract

Sepsis-induced coagulopathy is life-threatening in critically ill patients. Thrombin-antithrombin complex and thrombomodulin are key biomarkers, but no 20-year bibliometric analysis exists. We searched PubMed and Web of Science Core Collection (2006–2025) and analyzed 577 articles using CiteSpace and VOSviewer. Publications peaked in 2016 to 2018 and then declined. Japan, the United States, and China were the most productive; the United States had the highest citations. Hotspots focused on sepsis-induced coagulopathy, endothelial injury, and intensive care unit anticoagulation. Thrombin-antithrombin complex/thrombomodulin research is globally established, led by the United States. Future work should enhance international collaboration and develop multi-biomarker models.

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Cite

BibTeXRIS
BibTeX
@article{zhao2026bibliometric,
  title = {{Bibliometric analysis of key biomarkers in sepsis-induced coagulopathy (2006–2025)}},
  author = {Yidan Zhao and Huaxing Yao and Dong Lai and Pingping Xiao and Amei Li},
  journal = {Medicine},
  year = {2026},
  month = oct,
  doi = {10.1097/md.0000000000051327},
  url = {https://europepmc.org/article/PMC/PMC13727207},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Bibliometric analysis of key biomarkers in sepsis-induced coagulopathy (2006–2025)
AU  - Yidan Zhao
AU  - Huaxing Yao
AU  - Dong Lai
AU  - Pingping Xiao
AU  - Amei Li
PY  - 2026
DA  - 2026/10/30
JO  - Medicine
DO  - 10.1097/md.0000000000051327
UR  - https://europepmc.org/article/PMC/PMC13727207
AB  - Sepsis-induced coagulopathy is life-threatening in critically ill patients. Thrombin-antithrombin complex and thrombomodulin are key biomarkers, but no 20-year bibliometric analysis exists. We searched PubMed and Web of Science Core Collection (2006–2025) and analyzed 577 articles using CiteSpace and VOSviewer. Publications peaked in 2016 to 2018 and then declined. Japan, the United States, and China were the most productive; the United States had the highest citations. Hotspots focused on sepsis-induced coagulopathy, endothelial injury, and intensive care unit anticoagulation. Thrombin-antithrombin complex/thrombomodulin research is globally established, led by the United States. Future work should enhance international collaboration and develop multi-biomarker models.
SN  - 0304-5412
SN  - 1536-5964
SN  - 0025-7974
ER  -