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PreprintCC BYbioRxiv

A comprehensive map of the sequence basis of transcription initiation in humans

  • A. Y. He
  • C. Tian
  • A. Kundaje1
  1. 1Stanford University
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Abstract

Transcription initiation is a key marker of active enhancers and promoters. Here we describe an atlas of efficient and interpretable deep learning models trained on over 200 transcription initiation profiling experiments representing all major human organs and many cancer types. We show that our models accurately predict initiation patterns from local DNA sequence and decode their sequence determinants across diverse cellular contexts.

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Cite

BibTeXRIS
BibTeX
@misc{he2026comprehensive,
  title = {{A comprehensive map of the sequence basis of transcription initiation in humans}},
  author = {A. Y. He and C. Tian and A. Kundaje},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.29.762743},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.29.762743v1},
  note = {CC BY},
}
RIS
TY  - UNPB
TI  - A comprehensive map of the sequence basis of transcription initiation in humans
AU  - A. Y. He
AU  - C. Tian
AU  - A. Kundaje
PY  - 2026
DA  - 2026/10/29
PB  - bioRxiv
DO  - 10.64898/2026.10.29.762743
UR  - https://www.biorxiv.org/content/10.64898/2026.10.29.762743v1
AB  - Transcription initiation is a key marker of active enhancers and promoters. Here we describe an atlas of efficient and interpretable deep learning models trained on over 200 transcription initiation profiling experiments representing all major human organs and many cancer types. We show that our models accurately predict initiation patterns from local DNA sequence and decode their sequence determinants across diverse cellular contexts.
ER  -