Skip to content
DraconiticResearch
Search Sources API
194,226 studies31 sourcesUpdated 30 min ago
Peer-reviewedLicence not statedNature

Somatic mutations reveal the ontogeny of microglia in human ageing

  • Julia A. Belk1
  • Yaowen Zhang2
  • Emily E. Reilly2
  • Quanming Shi3,4
  • Daniel Dan Liu2,5
  • Nicole L. Womack-Gambrel5
  • Maarten van der Linde6,2
  • Lisa Ma2
  • Debasmita Paul2
  • Alejandro Medina Enciso2,7
  • Raja Sab Kalluru2
  • Jacob Weiss2
34 more authors
  • Rui Li4
  • Anna E. Eastman5
  • Chunfang Zhu2
  • Arnav Chakravarthy4
  • Syed Abbas Bukhari2
  • Dipabarna Bhattacharya2
  • S. Vijay Anand Raj5
  • Daniel J. Richard8
  • Simone Brioschi9,10
  • Matthew R. Chrostek2
  • Daniel C. Nachun2
  • Christopher Maximilian Arends2
  • Jayakrishnan Gopakumar2
  • Isak W. Tengesdal2
  • Ademar Bynum2
  • Shaneice Renee Mitchell2
  • Katalin D. Sandor2
  • Wenxi Zhang11,2
  • Badri Narayan Vardarajan12,13
  • Inma Cobos2
  • Donald E. Born2
  • Robert B. West2
  • Anne Brunet8
  • Marco Colonna10
  • Krishna Bharani2,14
  • Hannes S. Vogel2
  • Thomas Jude Montine2
  • Caitlin S. Latimer15
  • Irving L. Weissman2,5
  • Magdalena Matusiak2
  • Jody E. Hooper2
  • Christopher Dirk Keene15,16
  • Howard Y. Chang17,18,19
  • Siddhartha Jaiswal20,21
21 affiliations
  1. 1Department of Pathology, Stanford University, Stanford, CA, USA. [email protected]
  2. 2Department of Pathology, Stanford University, Stanford, CA, USA
  3. 3Amgen Research, South San Francisco, CA, USA
  4. 4Department of Dermatology, Stanford University, Stanford, CA, USA
  5. 5Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA
  6. 6Department of Pathology, Leiden University Medical Centre, Leiden, The Netherlands
  7. 7Sarafan ChEM-H, Stanford University, Stanford, CA, USA
  8. 8Department of Genetics, Stanford University, Stanford, CA, USA
  9. 9Center for Neuroimmunology and Glial Biology, Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX, USA
  10. 10Department of Pathology and Immunology, Washington University School of Medicine in Saint Louis, St Louis, MO, USA
  11. 11Department of Medicine, University of California San Francisco, San Francisco, CA, USA
  12. 12Department of Neurology, College of Physicians and Surgeons, Columbia University and the New York Presbyterian Hospital, New York, NY, USA
  13. 13Taub Institute for Research on Alzheimer's Disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA
  14. 14Department of Pathology, The Ohio State University Wexner Medical Center, Columbus, OH, USA
  15. 15Department of Laboratory Medicine and Pathology, University of Washington School of Medicine, Seattle, WA, USA
  16. 16Department of Pathology, University of California San Diego, La Jolla, CA, USA
  17. 17Amgen Research, South San Francisco, CA, USA. [email protected]
  18. 18Department of Dermatology, Stanford University, Stanford, CA, USA. [email protected]
  19. 19Department of Genetics, Stanford University, Stanford, CA, USA. [email protected]
  20. 20Department of Pathology, Stanford University, Stanford, CA, USA. [email protected]
  21. 21Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA, USA. [email protected]
Open at sourcePDFDOICite

Related

  1. WITHDRAWN: Heterozygous germline MSH3 mutations, and probably MLH3 mutations, act as classical tumour suppressors, leading to excess somatic deletion mutations, signature ID4 and increased colorectal cancer risk
    I. Soriano, K. Sherwood, J. C. Ward +10
    medRxivPreprintCC BY-NC-NDFull textHuman geneticsmedRxiv
  2. Ovarian Somatic Cells: Cellular Heterogeneity and Functional Dynamics Across Health, Ageing, and Disease
    Paola Rebuzzini, Andrea Fantinato, Giulia Brazzale +5
    CellsPeer-reviewedCC BY 4.0Full textEpidemiology & public healthCrossrefEurope PMC
  3. Somatic DDX41 mutations confer neomorphic splicing activity in the pathogenesis of myelodysplastic neoplasms
    R. Venkataraman, N. Puccio, T.-Y. Hsueh +21
    bioRxivPreprintAll rights reservedFull textOncologybioRxiv
  4. Integrative benchmarking and automation of clonal reconstruction of somatic mutations in single-sample tumor genome analysis.
    Marina Masliakova, Steve Lefever, Jo Vandesompele
    BMC bioinformaticsPeer-reviewedCC BYFull textOncologyEurope PMCPMC
  5. Genomic foundation model-derived disruption profiling links somatic mutations to cancer biology and clinical outcomes
    A. Nayak, T.-R. Lee, V. Agarwal +1
    medRxivPreprintCC BY-NC-NDFull textHuman geneticsmedRxiv

Cite

BibTeXRIS
BibTeX
@article{belk2026somatic,
  title = {{Somatic mutations reveal the ontogeny of microglia in human ageing}},
  author = {Julia A. Belk and Yaowen Zhang and Emily E. Reilly and Quanming Shi and Daniel Dan Liu and Nicole L. Womack-Gambrel and Maarten van der Linde and Lisa Ma and Debasmita Paul and Alejandro Medina Enciso and Raja Sab Kalluru and Jacob Weiss and Rui Li and Anna E. Eastman and Chunfang Zhu and Arnav Chakravarthy and Syed Abbas Bukhari and Dipabarna Bhattacharya and S. Vijay Anand Raj and Daniel J. Richard and Simone Brioschi and Matthew R. Chrostek and Daniel C. Nachun and Christopher Maximilian Arends and Jayakrishnan Gopakumar and Isak W. Tengesdal and Ademar Bynum and Shaneice Renee Mitchell and Katalin D. Sandor and Wenxi Zhang and Badri Narayan Vardarajan and Inma Cobos and Donald E. Born and Robert B. West and Anne Brunet and Marco Colonna and Krishna Bharani and Hannes S. Vogel and Thomas Jude Montine and Caitlin S. Latimer and Irving L. Weissman and Magdalena Matusiak and Jody E. Hooper and Christopher Dirk Keene and Howard Y. Chang and Siddhartha Jaiswal},
  journal = {Nature},
  year = {2026},
  month = jul,
  doi = {10.1038/s41586-026-10939-0},
  url = {https://doi.org/10.64898/2026.05.19.726366},
}
RIS
TY  - JOUR
TI  - Somatic mutations reveal the ontogeny of microglia in human ageing
AU  - Julia A. Belk
AU  - Yaowen Zhang
AU  - Emily E. Reilly
AU  - Quanming Shi
AU  - Daniel Dan Liu
AU  - Nicole L. Womack-Gambrel
AU  - Maarten van der Linde
AU  - Lisa Ma
AU  - Debasmita Paul
AU  - Alejandro Medina Enciso
AU  - Raja Sab Kalluru
AU  - Jacob Weiss
AU  - Rui Li
AU  - Anna E. Eastman
AU  - Chunfang Zhu
AU  - Arnav Chakravarthy
AU  - Syed Abbas Bukhari
AU  - Dipabarna Bhattacharya
AU  - S. Vijay Anand Raj
AU  - Daniel J. Richard
AU  - Simone Brioschi
AU  - Matthew R. Chrostek
AU  - Daniel C. Nachun
AU  - Christopher Maximilian Arends
AU  - Jayakrishnan Gopakumar
AU  - Isak W. Tengesdal
AU  - Ademar Bynum
AU  - Shaneice Renee Mitchell
AU  - Katalin D. Sandor
AU  - Wenxi Zhang
AU  - Badri Narayan Vardarajan
AU  - Inma Cobos
AU  - Donald E. Born
AU  - Robert B. West
AU  - Anne Brunet
AU  - Marco Colonna
AU  - Krishna Bharani
AU  - Hannes S. Vogel
AU  - Thomas Jude Montine
AU  - Caitlin S. Latimer
AU  - Irving L. Weissman
AU  - Magdalena Matusiak
AU  - Jody E. Hooper
AU  - Christopher Dirk Keene
AU  - Howard Y. Chang
AU  - Siddhartha Jaiswal
PY  - 2026
DA  - 2026/07/30
JO  - Nature
DO  - 10.1038/s41586-026-10939-0
UR  - https://doi.org/10.64898/2026.05.19.726366
SN  - 0028-0836
SN  - 1476-4687
ER  -