A Novel Phenolic From the Heartwood of Cotinus coggygria Scop. With Potential Neuroprotective Effects: In Silico and In Vitro Studies.
- 1State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Institute of Pharmaceutical Research, Tianjin, P. R. China.
Abstract
Seven known phenolic compounds (2-8) along with one new phenolic compound (1) were isolated from the heartwood of Cotinus coggygria Scop. (Anacardiaceae). Among them, compounds 3-5 are reported from the genus Cotinus for the first time, while compounds 2 and 6-8 are reported from the family Anacardiaceae for the first time. The structure of the new compound was elucidated by detailed spectroscopic analysis, including HR-ESI-MS, 1D, and 2D NMR experiments. In vitro assays showed that compound 1 attenuated glutamate-induced oxidative injury in HT22 cells (EC₅₀ = 3.852 µM, MTS assay) and inhibited TNF-α-induced NF‑κB activation in 293T luciferase reporter cells. Molecular docking suggested that compound 1 may bind to IKKβ, consistent with the observed NF‑κB inhibition. Preliminary structure-activity relationship trend analysis indicated that compounds possessing a 6″-O-rhamnose-containing disaccharide moiety (6-8) showed stronger apparent protective activity than the 6″-O -galloyl derivatives (1-5) under the present assay conditions. These preliminary findings suggest that cotinusin A (1) may warrant further investigation for its potential against glutamate-induced oxidative neuronal injury. However, whether the observed NF‑κB inhibitory activity translates into anti-neuroinflammatory effects in relevant models remains to be determined, and further mechanistic and in vivo studies are needed to establish its therapeutic potential.
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BibTeX
@article{meng2026novel,
title = {{A Novel Phenolic From the Heartwood of Cotinus coggygria Scop. With Potential Neuroprotective Effects: In Silico and In Vitro Studies.}},
author = {Caiwen Meng and Yi He and Zijia Wang and Hongyun Bai and Ruyi Wang and Xiaoliang Wang and Chunlai Zhao and Meichen Li},
journal = {Chemistry \& biodiversity},
year = {2026},
month = nov,
doi = {10.1002/cbdv.71890},
url = {https://europepmc.org/article/MED/42967484},
note = {CC BY},
}
RIS
TY - JOUR
TI - A Novel Phenolic From the Heartwood of Cotinus coggygria Scop. With Potential Neuroprotective Effects: In Silico and In Vitro Studies.
AU - Caiwen Meng
AU - Yi He
AU - Zijia Wang
AU - Hongyun Bai
AU - Ruyi Wang
AU - Xiaoliang Wang
AU - Chunlai Zhao
AU - Meichen Li
PY - 2026
DA - 2026/11/01
JO - Chemistry & biodiversity
DO - 10.1002/cbdv.71890
UR - https://europepmc.org/article/MED/42967484
AB - Seven known phenolic compounds (2-8) along with one new phenolic compound (1) were isolated from the heartwood of Cotinus coggygria Scop. (Anacardiaceae). Among them, compounds 3-5 are reported from the genus Cotinus for the first time, while compounds 2 and 6-8 are reported from the family Anacardiaceae for the first time. The structure of the new compound was elucidated by detailed spectroscopic analysis, including HR-ESI-MS, 1D, and 2D NMR experiments. In vitro assays showed that compound 1 attenuated glutamate-induced oxidative injury in HT22 cells (EC₅₀ = 3.852 µM, MTS assay) and inhibited TNF-α-induced NF‑κB activation in 293T luciferase reporter cells. Molecular docking suggested that compound 1 may bind to IKKβ, consistent with the observed NF‑κB inhibition. Preliminary structure-activity relationship trend analysis indicated that compounds possessing a 6″-O-rhamnose-containing disaccharide moiety (6-8) showed stronger apparent protective activity than the 6″-O -galloyl derivatives (1-5) under the present assay conditions. These preliminary findings suggest that cotinusin A (1) may warrant further investigation for its potential against glutamate-induced oxidative neuronal injury. However, whether the observed NF‑κB inhibitory activity translates into anti-neuroinflammatory effects in relevant models remains to be determined, and further mechanistic and in vivo studies are needed to establish its therapeutic potential.
SN - 1612-1872
SN - 1612-1880
ER -