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Peer-reviewedCC BY-NC-NDFood Chemistry: X

Interaction-driven chorismate metabolic reprogramming underlies

  • Huabin Tu
  • Guanyu Zhou1
  • Fanggen Tan2
  • Fan Yang1
  • Liangqiang Chen1
  • Jianjun Lu2
  • Jianghua Li3
  • Yanfeng Liu4
  • Jian Chen5
5 affiliations
  1. 1Guizhou Key Laboratory of Microbial Resources Exploration in Fermentation Industry, Kweichow Moutai Group, Renhuai 564500, Guizhou, China; Guizhou Provincial Laboratory of Biomanufacturing, Kweichow Moutai Group, Renhuai 564500, Guizhou, China
  2. 2Guizhou Key Laboratory of Microbial Resources Exploration in Fermentation Industry, Kweichow Moutai Group, Renhuai 564500, Guizhou, China
  3. 3School of Biotechnology and Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, China
  4. 4School of Biotechnology and Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, China; Co-Corresponding author.
  5. 5School of Biotechnology and Key Laboratory of Industrial Biotechnology, Ministry of Education, Jiangnan University, 1800 Lihu Avenue, Wuxi 214122, Jiangsu Province, China; Corresponding author.
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Abstract

High-temperature Daqu (HTD), the essential solid-state fermentation starter for premium Moutai-flavor Baijiu , reaches a peak temperature of 60–65 °C driven by microbial metabolic heat; yet the detailed metabolic mechanism underlying the Bacillus – Pediococcus thermogenic synergy remains largely unresolved. This study integrated isothermal microcalorimetry, time-resolved transcriptomics, and untargeted metabolomics to decipher this cooperative thermogenesis under heat stress, with further validation in a simulated HTD-making system. A network of metabolic interaction and flux redirection was identified, in which heat-induced cell turnover releases cellular nitrogen into a shared pool, and Pediococcus contributes aromatic amino acid biosynthesis that supports respiratory heat output in Bacillus . Chorismate was identified as a central metabolic branch point, where flux is redirected toward tyrosine and menaquinone biosynthesis to sustain metabolic turnover, enhance electron transport efficiency, and alleviate oxidative damage. These findings provide a theoretical basis for precise and standardized industrial production of HTD.

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Cite

BibTeXRIS
BibTeX
@article{tu2026interactiondriven,
  title = {{Interaction-driven chorismate metabolic reprogramming underlies}},
  author = {Huabin Tu and Guanyu Zhou and Fanggen Tan and Fan Yang and Liangqiang Chen and Jianjun Lu and Jianghua Li and Yanfeng Liu and Jian Chen},
  journal = {Food Chemistry: X},
  year = {2026},
  month = oct,
  doi = {10.1016/j.fochx.2026.104599},
  url = {https://doi.org/10.1016/j.fochx.2026.104599},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Interaction-driven chorismate metabolic reprogramming underlies
AU  - Huabin Tu
AU  - Guanyu Zhou
AU  - Fanggen Tan
AU  - Fan Yang
AU  - Liangqiang Chen
AU  - Jianjun Lu
AU  - Jianghua Li
AU  - Yanfeng Liu
AU  - Jian Chen
PY  - 2026
DA  - 2026/10/16
JO  - Food Chemistry: X
DO  - 10.1016/j.fochx.2026.104599
UR  - https://doi.org/10.1016/j.fochx.2026.104599
AB  - High-temperature Daqu (HTD), the essential solid-state fermentation starter for premium Moutai-flavor Baijiu , reaches a peak temperature of 60–65 °C driven by microbial metabolic heat; yet the detailed metabolic mechanism underlying the Bacillus – Pediococcus thermogenic synergy remains largely unresolved. This study integrated isothermal microcalorimetry, time-resolved transcriptomics, and untargeted metabolomics to decipher this cooperative thermogenesis under heat stress, with further validation in a simulated HTD-making system. A network of metabolic interaction and flux redirection was identified, in which heat-induced cell turnover releases cellular nitrogen into a shared pool, and Pediococcus contributes aromatic amino acid biosynthesis that supports respiratory heat output in Bacillus . Chorismate was identified as a central metabolic branch point, where flux is redirected toward tyrosine and menaquinone biosynthesis to sustain metabolic turnover, enhance electron transport efficiency, and alleviate oxidative damage. These findings provide a theoretical basis for precise and standardized industrial production of HTD.
SN  - 2590-1575
ER  -