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Peer-reviewedLicence not statedScience Translational Medicine

Deep learning–enabled discovery of antibiotics effective against Neisseria gonorrhoeae

  • Melis N. Anahtar1,2,3,4
  • Jacqueline A. Valeri2,3,4
  • Seyed Majed Modaresi2,3,4
  • Aarti Krishnan2,3,5,4
  • Nina M. Donghia4
  • Samantha G. Palace6
  • Erica J. Zheng2,7,4
  • Aakanksha Gulati4
  • Alicia C. Jorgenson4
  • Abidemi Junaid4
  • Parijat Bandyopadhyay2,3
  • Andreas Luttens2,3
13 more authors
  • Krishna Suresh8
  • Paige Edwards2,3
  • Felix J. Wong2,3,9
  • Yu Zhang2,3,4
  • Danilo Ritz10
  • Margaux Gaborieau11
  • Edmund Loh12,11
  • Massimiliano Gaetani13,14
  • Marie‐Stéphanie Aschtgen11
  • Amir Ata Saei11
  • Yonatan H. Grad6
  • Donald E. Ingber15,16,4
  • James J. Collins2,3,4
16 affiliations
  1. 1Departments of Pathology and Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
  2. 2Infectious Disease and Microbiome Program, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
  3. 3Institute for Medical Engineering and Science and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
  4. 4Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02215, USA
  5. 5Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA
  6. 6Department of Immunology and Infectious Diseases, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA
  7. 7Program in Chemical Biology, Harvard University, Cambridge, MA 02138, USA
  8. 8Harvard Medical School, Boston, MA 02115, USA
  9. 9Integrated Biosciences Inc., Redwood City, CA 94065, USA
  10. 10Proteomics Core Facility, Biozentrum, University of Basel, Basel CH-4056, Switzerland
  11. 11Department of Microbiology, Tumor, and Cell Biology, Karolinska Institute, 171 77 Stockholm, Sweden
  12. 12Clinical Microbiology, Karolinska University Hospital, 171 76 Stockholm, Sweden
  13. 13Chemical Proteomics Unit, Science for Life Laboratory (SciLifeLab), 171 77 Stockholm, Sweden
  14. 14Division of Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, 17 177 Stockholm, Sweden
  15. 15Harvard John A. Paulson School of Engineering and Applied Sciences, Cambridge, MA 02539, USA
  16. 16Vascular Biology Program and Department of Surgery, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA
Open at sourceDOICite

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Cite

BibTeXRIS
BibTeX
@article{anahtar2026deep,
  title = {{Deep learning–enabled discovery of antibiotics effective against Neisseria gonorrhoeae}},
  author = {Melis N. Anahtar and Jacqueline A. Valeri and Seyed Majed Modaresi and Aarti Krishnan and Nina M. Donghia and Samantha G. Palace and Erica J. Zheng and Aakanksha Gulati and Alicia C. Jorgenson and Abidemi Junaid and Parijat Bandyopadhyay and Andreas Luttens and Krishna Suresh and Paige Edwards and Felix J. Wong and Yu Zhang and Danilo Ritz and Margaux Gaborieau and Edmund Loh and Massimiliano Gaetani and Marie‐Stéphanie Aschtgen and Amir Ata Saei and Yonatan H. Grad and Donald E. Ingber and James J. Collins},
  journal = {Science Translational Medicine},
  year = {2026},
  month = jun,
  doi = {10.1126/scitranslmed.ads4699},
  url = {https://pmc.ncbi.nlm.nih.gov/articles/PMC13459759/},
}
RIS
TY  - JOUR
TI  - Deep learning–enabled discovery of antibiotics effective against Neisseria gonorrhoeae
AU  - Melis N. Anahtar
AU  - Jacqueline A. Valeri
AU  - Seyed Majed Modaresi
AU  - Aarti Krishnan
AU  - Nina M. Donghia
AU  - Samantha G. Palace
AU  - Erica J. Zheng
AU  - Aakanksha Gulati
AU  - Alicia C. Jorgenson
AU  - Abidemi Junaid
AU  - Parijat Bandyopadhyay
AU  - Andreas Luttens
AU  - Krishna Suresh
AU  - Paige Edwards
AU  - Felix J. Wong
AU  - Yu Zhang
AU  - Danilo Ritz
AU  - Margaux Gaborieau
AU  - Edmund Loh
AU  - Massimiliano Gaetani
AU  - Marie‐Stéphanie Aschtgen
AU  - Amir Ata Saei
AU  - Yonatan H. Grad
AU  - Donald E. Ingber
AU  - James J. Collins
PY  - 2026
DA  - 2026/06/17
JO  - Science Translational Medicine
DO  - 10.1126/scitranslmed.ads4699
UR  - https://pmc.ncbi.nlm.nih.gov/articles/PMC13459759/
SN  - 1946-6234
SN  - 1946-6242
ER  -