Intraosseous Angiolipoma of the Maxilla: First Reported Case With a Review of the Literature.
- 1Department of Oral and Maxillofacial Surgery, School of Dentistry Shahid Beheshti University of Medical Sciences Tehran Iran.
- 2Dental Research Center, Research Institute of Dental Sciences, School of Dentistry Shahid Beheshti University of Medical Sciences Tehran Iran.
- 3Department of Oral and Maxillofacial Pathology, School of Dentistry Shahid Beheshti University of Medical Sciences Tehran Iran.
Abstract
Angiolipomas are benign mesenchymal neoplasms composed of mature adipocytes and vascular channels, typically occurring in subcutaneous tissue. Intraosseous is extremely rare and has been described in only 22 cases in the previous studies, affecting mainly the mandible, calvarium, ribs, and long bones. To our knowledge, there has not been one reported case in the maxilla. We report the first case of intraosseous angiolipoma of the maxilla and review the literature to emphasize its diagnostic challenge and clinical significance. A 46-year-old male patient presented for routine dental checkup with no symptoms and an uneventful clinical examination. His past medical history was extraction of maxillary molars and surgical removal of radicular cysts from the same area five years ago. Panoramic radiograph showed well-defined unilocular radiolucency in the left posterior maxilla. Cone-beam computed tomography established cortical perforation of the buccal and palatal plates and sinus floor involvement. Based on imaging and history, a preliminary diagnosis of residual cyst was rendered. Enucleation and curettage with primary closure was performed to manage the lesion. During surgery, the mass was found to be adherent to the buccal fat pad and surrounding musculature. The excised specimen was 2.5 × 1.5 × 1.1 cm and yellowish in hue. Histopathology revealed mature adipose tissue scattered with several thin-walled vessels in a lobulated pattern covered with a fibrous capsule. There was evidence of muscle fibers, hemorrhage, and nerve bundles, however no malignancy or atypia was observed. The final diagnosis was intraosseous angiolipoma. The lesion was removed by surgery, and the postoperative course was uneventful. No recurrence was observed during 1-year follow-up. This article presents the first case of intraosseous angiolipoma of the maxilla, contributing to the known anatomic distribution of this tumor.
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BibTeX
@article{shafiei2026intraosseous,
title = {{Intraosseous Angiolipoma of the Maxilla: First Reported Case With a Review of the Literature.}},
author = {Shervin Shafiei and Armin Khaleghi and Hamidreza Arefifard and Nafise Shamloo},
journal = {Clinical case reports},
year = {2026},
month = nov,
doi = {10.1002/ccr3.73705},
url = {https://europepmc.org/article/MED/42996782},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Intraosseous Angiolipoma of the Maxilla: First Reported Case With a Review of the Literature.
AU - Shervin Shafiei
AU - Armin Khaleghi
AU - Hamidreza Arefifard
AU - Nafise Shamloo
PY - 2026
DA - 2026/11/05
JO - Clinical case reports
DO - 10.1002/ccr3.73705
UR - https://europepmc.org/article/MED/42996782
AB - Angiolipomas are benign mesenchymal neoplasms composed of mature adipocytes and vascular channels, typically occurring in subcutaneous tissue. Intraosseous is extremely rare and has been described in only 22 cases in the previous studies, affecting mainly the mandible, calvarium, ribs, and long bones. To our knowledge, there has not been one reported case in the maxilla. We report the first case of intraosseous angiolipoma of the maxilla and review the literature to emphasize its diagnostic challenge and clinical significance. A 46-year-old male patient presented for routine dental checkup with no symptoms and an uneventful clinical examination. His past medical history was extraction of maxillary molars and surgical removal of radicular cysts from the same area five years ago. Panoramic radiograph showed well-defined unilocular radiolucency in the left posterior maxilla. Cone-beam computed tomography established cortical perforation of the buccal and palatal plates and sinus floor involvement. Based on imaging and history, a preliminary diagnosis of residual cyst was rendered. Enucleation and curettage with primary closure was performed to manage the lesion. During surgery, the mass was found to be adherent to the buccal fat pad and surrounding musculature. The excised specimen was 2.5 × 1.5 × 1.1 cm and yellowish in hue. Histopathology revealed mature adipose tissue scattered with several thin-walled vessels in a lobulated pattern covered with a fibrous capsule. There was evidence of muscle fibers, hemorrhage, and nerve bundles, however no malignancy or atypia was observed. The final diagnosis was intraosseous angiolipoma. The lesion was removed by surgery, and the postoperative course was uneventful. No recurrence was observed during 1-year follow-up. This article presents the first case of intraosseous angiolipoma of the maxilla, contributing to the known anatomic distribution of this tumor.
SN - 2050-0904
ER -