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Peer-reviewedCC BY 4.0Frontiers in Parasitology

Evaluating the impact of homoeopathy in managing the morbidity associated with grade III and IV lower limb lymphoedema in adults with lymphatic filariasis

  • Panaparambil Azis Suhana1
  • Jain Vij Shruti1,2
  • Sujata Choudhury3,4
  • Jaya Gupta1
  • Vasudeva Guddattu5
  • Prakash Kumar Sahoo6
  • Charu Sehgal1
  • Preeti Bhandari3
  • Monalisha Das3
  • Prasad Varamballi7
  • Subhash Kaushik1
7 affiliations
  1. 1Central Council for Research in Homoeopathy, Ministry of Ayush, Government of India, New Delhi, India
  2. 2National Institute of Homoeopathy, Ministry of Ayush, Government of India, New Delhi, India
  3. 3Regional Research Institute for Homoeopathy, Puri, Odisha, India
  4. 4Drug Proving Unit (Homoeopathy), Bhubaneswar, Odisha, India
  5. 5Department of Applied Statistics and Data Science, Prasanna School of Public Health, Manipal Academy of Higher Education, Manipal, Karnataka, India
  6. 6ICMR-Regional Medical Research Centre, Bhubaneswar, Department of Health Research, Ministry of Health & Family Welfare, Government of India, Odisha, India
  7. 7Manipal Institute of Virology, Manipal Academy of Higher Education, Manipal, Karnataka, India
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Abstract

Introduction: Lymphatic filariasis is a major public health burden, particularly in endemic regions, with millions suffering from chronic lymphoedema and hydrocele. While mass drug administration aims to restrict transmission, effective morbidity management remains a significant challenge. Homoeopathy has reported potential in managing lymphoedema, yet evidence in cases of grade III and IV lymphoedema is limited.

Methods: This open-label, exploratory, interventional study, conducted at the Regional Research Institute for Homoeopathy, Puri, Odisha, India, aimed to evaluate the effects of individualized homoeopathic medicines in managing grade III/IV unilateral/bilateral lower-limb lymphoedema associated with lymphatic filariasis. Outcomes included changes in limb circumference (Australasian Lymphology Association standards), limb volume (Water Displacement Method), health-related quality of life (7D5L scale), dermatological changes (Dermatology Life Quality Index), acute adenolymphangitis episodes, skin health, and serological markers over one year. A total of 104 eligible participants were enrolled, and followed-up monthly for one year. 61 participants dropped out of the study, and 43 participants successfully completed all the follow-ups.

Results: Statistically significant improvements were observed in quality of life and dermatological indices (p-value < 0.0001), along with alleviation of limb volume. Decreased Og4C3 and TNF-α levels, resolution of entry lesions and ulcers, and reduction in occurrence of fungal infections were documented.

Discussion: The study demonstrated the potential benefits of homoeopathy in managing advanced filarial lymphoedema by improving quality of life. Further controlled studies with larger sample are warranted.

Clinical trial registration: https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MjY2NzE=&Enc=&userName=, identifier CTRI/2018/06/014591.

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Cite

BibTeXRIS
BibTeX
@article{suhana2026evaluating,
  title = {{Evaluating the impact of homoeopathy in managing the morbidity associated with grade III and IV lower limb lymphoedema in adults with lymphatic filariasis}},
  author = {Panaparambil Azis Suhana and Jain Vij Shruti and Sujata Choudhury and Jaya Gupta and Vasudeva Guddattu and Prakash Kumar Sahoo and Charu Sehgal and Preeti Bhandari and Monalisha Das and Prasad Varamballi and Subhash Kaushik},
  journal = {Frontiers in Parasitology},
  year = {2026},
  month = oct,
  doi = {10.3389/fpara.2026.1939673},
  url = {https://doi.org/10.3389/fpara.2026.1939673},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Evaluating the impact of homoeopathy in managing the morbidity associated with grade III and IV lower limb lymphoedema in adults with lymphatic filariasis
AU  - Panaparambil Azis Suhana
AU  - Jain Vij Shruti
AU  - Sujata Choudhury
AU  - Jaya Gupta
AU  - Vasudeva Guddattu
AU  - Prakash Kumar Sahoo
AU  - Charu Sehgal
AU  - Preeti Bhandari
AU  - Monalisha Das
AU  - Prasad Varamballi
AU  - Subhash Kaushik
PY  - 2026
DA  - 2026/10/22
JO  - Frontiers in Parasitology
DO  - 10.3389/fpara.2026.1939673
UR  - https://doi.org/10.3389/fpara.2026.1939673
AB  - Introduction: Lymphatic filariasis is a major public health burden, particularly in endemic regions, with millions suffering from chronic lymphoedema and hydrocele. While mass drug administration aims to restrict transmission, effective morbidity management remains a significant challenge. Homoeopathy has reported potential in managing lymphoedema, yet evidence in cases of grade III and IV lymphoedema is limited.  Methods: This open-label, exploratory, interventional study, conducted at the Regional Research Institute for Homoeopathy, Puri, Odisha, India, aimed to evaluate the effects of individualized homoeopathic medicines in managing grade III/IV unilateral/bilateral lower-limb lymphoedema associated with lymphatic filariasis. Outcomes included changes in limb circumference (Australasian Lymphology Association standards), limb volume (Water Displacement Method), health-related quality of life (7D5L scale), dermatological changes (Dermatology Life Quality Index), acute adenolymphangitis episodes, skin health, and serological markers over one year. A total of 104 eligible participants were enrolled, and followed-up monthly for one year. 61 participants dropped out of the study, and 43 participants successfully completed all the follow-ups.  Results: Statistically significant improvements were observed in quality of life and dermatological indices (p-value < 0.0001), along with alleviation of limb volume. Decreased Og4C3 and TNF-α levels, resolution of entry lesions and ulcers, and reduction in occurrence of fungal infections were documented.  Discussion: The study demonstrated the potential benefits of homoeopathy in managing advanced filarial lymphoedema by improving quality of life. Further controlled studies with larger sample are warranted.  Clinical trial registration: https://ctri.nic.in/Clinicaltrials/pmaindet2.php?EncHid=MjY2NzE=&Enc=&userName=, identifier CTRI/2018/06/014591.
SN  - 2813-2424
ER  -