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Peer-reviewedCC BY-NC-NDOrganic letters

Rh-Catalyzed Cascade C-H Functionalization/Annulation of Ketimine Directed Arenes with Vinylcyclopropanes: Access to Bridged Azaheterocycles.

  • Swati Samantaray1
  • Sajal Roy1
  • Mahesh Samantaray2
  • Tharmalingam Punniyamurthy1
  1. 1Department of Chemistry, Indian Institute of Technology Guwahati, Guwahati-781039, India.
  2. 2Department of Translational Medicine, All India Institute of Medical Sciences, Bhopal-462020, India.
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Abstract

Rh-catalyzed cascade C-H functionalization/annulation of ketimine-directed arenes with vinylcyclopropanes has been accomplished to access N-bridged cyclic frameworks. The procedure can be extended to vinylaziridine, vinyloxirane, and vinyl ethylene carbonate to furnish spirotetrahydroisoquinoline and spiroindane scaffolds. The versatile reactivity of the vinyl strained rings, functional group tolerance, and photophysical/molecular docking studies of the representative examples are the important practical features.

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Cite

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BibTeX
@article{samantaray2026rhcatalyzed,
  title = {{Rh-Catalyzed Cascade C-H Functionalization/Annulation of Ketimine Directed Arenes with Vinylcyclopropanes: Access to Bridged Azaheterocycles.}},
  author = {Swati Samantaray and Sajal Roy and Mahesh Samantaray and Tharmalingam Punniyamurthy},
  journal = {Organic letters},
  year = {2026},
  month = oct,
  doi = {10.1021/acs.orglett.6c03868},
  url = {https://europepmc.org/article/MED/42917741},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Rh-Catalyzed Cascade C-H Functionalization/Annulation of Ketimine Directed Arenes with Vinylcyclopropanes: Access to Bridged Azaheterocycles.
AU  - Swati Samantaray
AU  - Sajal Roy
AU  - Mahesh Samantaray
AU  - Tharmalingam Punniyamurthy
PY  - 2026
DA  - 2026/10/01
JO  - Organic letters
DO  - 10.1021/acs.orglett.6c03868
UR  - https://europepmc.org/article/MED/42917741
AB  - Rh-catalyzed cascade C-H functionalization/annulation of ketimine-directed arenes with vinylcyclopropanes has been accomplished to access N-bridged cyclic frameworks. The procedure can be extended to vinylaziridine, vinyloxirane, and vinyl ethylene carbonate to furnish spirotetrahydroisoquinoline and spiroindane scaffolds. The versatile reactivity of the vinyl strained rings, functional group tolerance, and photophysical/molecular docking studies of the representative examples are the important practical features.
SN  - 1523-7060
SN  - 1523-7052
ER  -