BUB signaling in cancer and molecular insights into targeted therapies
Abstract
The Spindle Assembly Checkpoint (SAC) is vital for proper chromosome segregation during cell division and for maintaining genomic integrity; its disruption can cause aneuploidy and tumors. The BUB gene family ensures SAC fidelity by regulating kinetochore–microtubule attachments and mitotic progression. Dysregulation leads to chromosomal instability (CIN), contributing to cancer progression, heterogeneity, metastasis, and therapy resistance. Beyond mitosis, BUB proteins influence DNA repair, chromatin remodeling, transcription, and immune responses. They interact with cell cycle and genome stability pathways, impacting cancer prognosis and therapy response. Research is ongoing to validate BUB proteins as biomarkers and develop inhibitors, possibly combined with immunotherapies or DNA-damaging agents for resistant tumors. This review summarizes their functions, highlighting their potential in personalized cancer treatment.
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BibTeX
@article{baweja2026signaling,
title = {{BUB signaling in cancer and molecular insights into targeted therapies}},
author = {Bhavika Baweja and Chainsee Saini and Prerna Vats and Rashi Soni and Kritika Jangir and Prachi Patidar and Ashok Kumar and Rajeev Nema},
journal = {Communications Biology},
year = {2026},
month = oct,
doi = {10.1038/s42003-026-10976-5},
url = {https://www.nature.com/articles/s42003-026-10976-5},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - BUB signaling in cancer and molecular insights into targeted therapies
AU - Bhavika Baweja
AU - Chainsee Saini
AU - Prerna Vats
AU - Rashi Soni
AU - Kritika Jangir
AU - Prachi Patidar
AU - Ashok Kumar
AU - Rajeev Nema
PY - 2026
DA - 2026/10/16
JO - Communications Biology
DO - 10.1038/s42003-026-10976-5
UR - https://www.nature.com/articles/s42003-026-10976-5
AB - The Spindle Assembly Checkpoint (SAC) is vital for proper chromosome segregation during cell division and for maintaining genomic integrity; its disruption can cause aneuploidy and tumors. The BUB gene family ensures SAC fidelity by regulating kinetochore–microtubule attachments and mitotic progression. Dysregulation leads to chromosomal instability (CIN), contributing to cancer progression, heterogeneity, metastasis, and therapy resistance. Beyond mitosis, BUB proteins influence DNA repair, chromatin remodeling, transcription, and immune responses. They interact with cell cycle and genome stability pathways, impacting cancer prognosis and therapy response. Research is ongoing to validate BUB proteins as biomarkers and develop inhibitors, possibly combined with immunotherapies or DNA-damaging agents for resistant tumors. This review summarizes their functions, highlighting their potential in personalized cancer treatment.
SN - 2399-3642
ER -