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Peer-reviewedCC BY-NC-NDBMC research notes

Investigating long non-coding RNA (lncRNA) HOTAIR expression changes in ischemic stroke patients.

  • Alia Saberi1
  • Niloufar Nabavi1
  • Amirreza Ghayeghran1
  • Zivar Salehi2
  • Yaser Moaddabi1
  • Mohammad Ebrahim Ghaffari3
  • Haniyeh Haghanipor4
  • Sara Khoshdooz5
  • Ali Bonyad4
5 affiliations
  1. 1Neuroscience Research Centre, Neurology Department, Poursina Hospital, Guilan University of Medical Sciences, Guilan, Iran.
  2. 2Department of Biology, Faculty of Sciences, University of Guilan, Rasht, Iran.
  3. 3Neuroscience Research Center, Trauma Institute, Guilan University of Medical Sciences, Rasht, Iran.
  4. 4Faculty of Medicine, Guilan University of Medical Science, Rasht, Iran.
  5. 5Faculty of Medicine, Guilan University of Medical Science, Rasht, Iran. [email protected].
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Abstract

Background

Ischemic stroke (IS), a leading global health problem, is caused by interrupted blood flow in the brain, often due to clotting or artery constriction. Long non-coding RNAs (lncRNAs), particularly HOX transcript antisense intergenic RNA (HOTAIR), are pivotal in stroke pathophysiology.Aim

This study focused on the expression levels of HOTAIR lncRNA in ischemic stroke patients.Methods and materials

This comparative cross-sectional study with 100 participants: 50 IS patients and 50 patients without IS serving as controls. The study gathered demographic data, disease specifics, and medication history. Blood samples were analyzed for HOTAIR lncRNA expression levels.Results

This study showed significantly higher expression levels of HOTAIR lncRNA among IS patients compared to the control group (5.73 ± 0.75 vs. 2.35 ± 0.29; P < 0.001), with an average increase of 3.19 units compared to the control group (P < 0.001) after adjusting the independent variables. Additionally, participants with hypertension had an average increase of 0.36 units in of HOTAIR lncRNA expression compared to the control group (P = 0.041).Conclusion

Our study found that HOTAIR lncRNA levels are significantly higher in IS patients and may be associated with a history of hypertension. diseases. This suggests that HOTAIR lncRNA could be a useful biomarker for stroke and related conditions.

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Cite

BibTeXRIS
BibTeX
@article{saberi2026investigating,
  title = {{Investigating long non-coding RNA (lncRNA) HOTAIR expression changes in ischemic stroke patients.}},
  author = {Alia Saberi and Niloufar Nabavi and Amirreza Ghayeghran and Zivar Salehi and Yaser Moaddabi and Mohammad Ebrahim Ghaffari and Haniyeh Haghanipor and Sara Khoshdooz and Ali Bonyad},
  journal = {BMC research notes},
  year = {2026},
  month = jul,
  doi = {10.1186/s13104-025-07487-7},
  url = {https://europepmc.org/article/MED/42902418},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Investigating long non-coding RNA (lncRNA) HOTAIR expression changes in ischemic stroke patients.
AU  - Alia Saberi
AU  - Niloufar Nabavi
AU  - Amirreza Ghayeghran
AU  - Zivar Salehi
AU  - Yaser Moaddabi
AU  - Mohammad Ebrahim Ghaffari
AU  - Haniyeh Haghanipor
AU  - Sara Khoshdooz
AU  - Ali Bonyad
PY  - 2026
DA  - 2026/07/01
JO  - BMC research notes
DO  - 10.1186/s13104-025-07487-7
UR  - https://europepmc.org/article/MED/42902418
AB  - Background  Ischemic stroke (IS), a leading global health problem, is caused by interrupted blood flow in the brain, often due to clotting or artery constriction. Long non-coding RNAs (lncRNAs), particularly HOX transcript antisense intergenic RNA (HOTAIR), are pivotal in stroke pathophysiology.Aim  This study focused on the expression levels of HOTAIR lncRNA in ischemic stroke patients.Methods and materials  This comparative cross-sectional study with 100 participants: 50 IS patients and 50 patients without IS serving as controls. The study gathered demographic data, disease specifics, and medication history. Blood samples were analyzed for HOTAIR lncRNA expression levels.Results  This study showed significantly higher expression levels of HOTAIR lncRNA among IS patients compared to the control group (5.73 ± 0.75 vs. 2.35 ± 0.29; P < 0.001), with an average increase of 3.19 units compared to the control group (P < 0.001) after adjusting the independent variables. Additionally, participants with hypertension had an average increase of 0.36 units in of HOTAIR lncRNA expression compared to the control group (P = 0.041).Conclusion  Our study found that HOTAIR lncRNA levels are significantly higher in IS patients and may be associated with a history of hypertension. diseases. This suggests that HOTAIR lncRNA could be a useful biomarker for stroke and related conditions.
SN  - 1756-0500
ER  -