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Peer-reviewedCC BY 4.0Supportive Care in Cancer

Global perspectives on MASCC clinical practice guidelines: awareness, implementation and insights to inform future updates

  • Ragda Abdalla-Aslan1,2
  • Paola Alberti3
  • Nicole Blijlevens4
  • Pierluigi Bonomo5
  • Joanne Bowen6
  • Julia S. Bruno7
  • Raymond J. Chan8
  • Yin Ting Cheung9
  • Andrew Davies10
  • Mellar Davis11
  • Sharon Elad12
  • Joel Epstein13,14
19 more authors
  • Darren Fernandes15
  • Jason L. Freedman16
  • Nicolas H. Hart8,17
  • Hirotoshi Iihara18,19
  • Michael Jefford20,21
  • Daniel Peter Johnstone22
  • Amber S. Kleckner23
  • Bogda Koczwara24,25
  • Grigorios Kotronoulas26
  • Emma Munro27
  • Barbara Murphy28
  • Midori Nakagaki29
  • Enrique Soto-Perez-de-Celis30
  • Stephen Sonis31,32
  • Nikolaos Tsoukalas33,34
  • Anna Ugalde35
  • Corina van den Hurk36,37
  • Hannah Rose Wardill38,39
  • Paolo Bossi40
40 affiliations
  1. 1Technion Israel Institute of Technology, Faculty of Medicine, Technion City, Haifa, 3200003 Israel
  2. 2Department of Oral and Maxillofacial Surgery, Rambam Health Care Campus, Haifa, Israel
  3. 3School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy
  4. 4Department of Hematology, Radboud University Medical Centre, Nijmegen, The Netherlands
  5. 5Radiation Oncology, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy
  6. 6School of Pharmacy and Biomedical Science, Adelaide University, Adelaide, Australia
  7. 7Instituto de Ensino E Pesquisa, Hospital Sírio-Libanês, São Paulo, Brazil
  8. 8Flinders LiveWell Cancer Research Centre, Caring Futures Institute, College of Health and Enablement, Flinders University, Adelaide, SA Australia
  9. 9School of Pharmacy, Faculty of Medicine, the Chinese University of Hong Kong, Shatin, Hong Kong SAR Hong Kong
  10. 10School of Medicine, Trinity College Dublin, Dublin, Ireland
  11. 11Palliative Medicine, Division of Oncology Supportive Care, Levine Cancer Institute, Charlotte, NC USA
  12. 12Oral Medicine, Eastman Institute for Oral Health, University of Rochester Medical Center, Rochester, NY USA
  13. 13Cedars Sinai National Medical Center Los Angeles, Los Angeles, CA USA
  14. 14Cancer Dentistry, Division of Otolaryngology and Head and Neck Surgery, City of Hope, Duarte, CA USA
  15. 15The Department of Gastroenterology, Nottingham Digestive Diseases Centre, Derby Road, Nottingham, NG7 2UH UK
  16. 16Division of Oncology, Children’s Hospital of Philadelphia, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA USA
  17. 17Human Performance Research Centre, INSIGHT Research Institute, University of Technology Sydney (UTS), Sydney, NSW Australia
  18. 18Department of Pharmacy, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194 Japan
  19. 19Cancer Center, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194 Japan
  20. 20Centre for Health Services Research in Cancer, Australian Cancer Survivorship Centre, and Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria Australia
  21. 21Sir Peter MacCallum Department of Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria Australia
  22. 22Adelaide University, Adelaide, Australia
  23. 23Department of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, MD 21201 USA
  24. 24Australian Research Centre for Cancer Survivorship, UNSW Medicine & Health, UNSW Sydney, in partnership with Cancer Council NSW, Sydney, Australia
  25. 25Flinders University, Adelaide, Australia
  26. 26School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, UK
  27. 27Haematology and Bone Marrow Transplant Cancer Care Services, Royal Brisbane and Women’s Hospital, Herston, Queensland Australia
  28. 28Vanderbilt University Medical Center, Nashville, TN USA
  29. 29Pharmacy Department, Royal Brisbane and Women’s Hospital, Herston, Queensland Australia
  30. 30Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, CO USA
  31. 31Divisions of Oral Medicine, Brigham and Women’s Hospital and Dana-Farber Cancer Institute, Boston, MA USA
  32. 32Biomodels. LLC and Primary Endpoint Solutions, LLC, Waltham, MA USA
  33. 33Oncology Department, Veterans Hospital (417 NIMTS), Athens, Greece
  34. 34Henry Dunant Hospital Center, Athens, Greece
  35. 35Institute for Health Transformation, Quality and Patient Safety, Deakin University, Geelong, Victoria Australia
  36. 36Catharina Hospital, Eindhoven, The Netherlands
  37. 37Santeon, Utrecht, The Netherlands
  38. 38School of Pharmacy and Biomedical Science, College of Health, Adelaide University, Adelaide, South Australia Australia
  39. 39Supportive Oncology Research Group, Precision Cancer Medicine Theme, South Australian Health and Medical Research Institute, Adelaide, South Australia Australia
  40. 40Department of Biomedical Sciences, Humanitas University, IRCCS Humanitas Research Hospital, Milan, Italy
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Abstract

Purpose: The Multinational Association of Supportive Care in Cancer (MASCC) is internationally recognized for developing evidence-based Clinical Practice Guidelines (CPGs) for managing cancer or treatment–related toxicities, but their uptake remains uncertain. This study aimed to evaluate global awareness, utilization, and perceptions of MASCC CPGs, to inform strategies to enhance future updates and promote their implementation.

Methods: An international online survey was distributed via the MASCC platform between February and March 2025 to healthcare professionals specialized in supportive care in cancer. The survey included both closed- and open-ended questions addressing awareness, usage, perceived strengths and limitations, implementation challenges, and suggestions for improvement.

Results: A total of 423 responses were received, 264 (63%) from MASCC members. Participants represented all world regions, with 271 (65%) having 11–20 or more years of clinical experience. Overall, 302 (78%) reported routinely using MASCC CPGs in the management of cancer or treatment-related toxicities. Even among non-members, MASCC CPGs were cited as the most frequently used guidelines compared with other sources. The mucositis and antiemetics CPGs were the most recognized and applied. Key facilitators included the guidelines’ strong evidence and multidisciplinary development. Reported barriers included limited availability or high cost of recommended interventions. Respondents suggested improvements related to the timing of updates, dissemination strategies, and the inclusion of patient-facing guidelines.

Conclusions: MASCC CPGs are widely recognized and valued globally, yet implementation remains variable. Targeted efforts to address resource constraints and enhance dissemination may strengthen their global awareness and implementation.

Supplementary information: The online version contains supplementary material available at https://doi.org/10.1007/s00520-026-11388-1.

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Cite

BibTeXRIS
BibTeX
@article{abdallaaslan2026global,
  title = {{Global perspectives on MASCC clinical practice guidelines: awareness, implementation and insights to inform future updates}},
  author = {Ragda Abdalla-Aslan and Paola Alberti and Nicole Blijlevens and Pierluigi Bonomo and Joanne Bowen and Julia S. Bruno and Raymond J. Chan and Yin Ting Cheung and Andrew Davies and Mellar Davis and Sharon Elad and Joel Epstein and Darren Fernandes and Jason L. Freedman and Nicolas H. Hart and Hirotoshi Iihara and Michael Jefford and Daniel Peter Johnstone and Amber S. Kleckner and Bogda Koczwara and Grigorios Kotronoulas and Emma Munro and Barbara Murphy and Midori Nakagaki and Enrique Soto-Perez-de-Celis and Stephen Sonis and Nikolaos Tsoukalas and Anna Ugalde and Corina van den Hurk and Hannah Rose Wardill and Paolo Bossi},
  journal = {Supportive Care in Cancer},
  year = {2026},
  month = nov,
  doi = {10.1007/s00520-026-11388-1},
  url = {https://doi.org/10.1007/s00520-026-11388-1},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Global perspectives on MASCC clinical practice guidelines: awareness, implementation and insights to inform future updates
AU  - Ragda Abdalla-Aslan
AU  - Paola Alberti
AU  - Nicole Blijlevens
AU  - Pierluigi Bonomo
AU  - Joanne Bowen
AU  - Julia S. Bruno
AU  - Raymond J. Chan
AU  - Yin Ting Cheung
AU  - Andrew Davies
AU  - Mellar Davis
AU  - Sharon Elad
AU  - Joel Epstein
AU  - Darren Fernandes
AU  - Jason L. Freedman
AU  - Nicolas H. Hart
AU  - Hirotoshi Iihara
AU  - Michael Jefford
AU  - Daniel Peter Johnstone
AU  - Amber S. Kleckner
AU  - Bogda Koczwara
AU  - Grigorios Kotronoulas
AU  - Emma Munro
AU  - Barbara Murphy
AU  - Midori Nakagaki
AU  - Enrique Soto-Perez-de-Celis
AU  - Stephen Sonis
AU  - Nikolaos Tsoukalas
AU  - Anna Ugalde
AU  - Corina van den Hurk
AU  - Hannah Rose Wardill
AU  - Paolo Bossi
PY  - 2026
DA  - 2026/11/04
JO  - Supportive Care in Cancer
DO  - 10.1007/s00520-026-11388-1
UR  - https://doi.org/10.1007/s00520-026-11388-1
AB  - Purpose: The Multinational Association of Supportive Care in Cancer (MASCC) is internationally recognized for developing evidence-based Clinical Practice Guidelines (CPGs) for managing cancer or treatment–related toxicities, but their uptake remains uncertain. This study aimed to evaluate global awareness, utilization, and perceptions of MASCC CPGs, to inform strategies to enhance future updates and promote their implementation.  Methods: An international online survey was distributed via the MASCC platform between February and March 2025 to healthcare professionals specialized in supportive care in cancer. The survey included both closed- and open-ended questions addressing awareness, usage, perceived strengths and limitations, implementation challenges, and suggestions for improvement.  Results: A total of 423 responses were received, 264 (63%) from MASCC members. Participants represented all world regions, with 271 (65%) having 11–20 or more years of clinical experience. Overall, 302 (78%) reported routinely using MASCC CPGs in the management of cancer or treatment-related toxicities. Even among non-members, MASCC CPGs were cited as the most frequently used guidelines compared with other sources. The mucositis and antiemetics CPGs were the most recognized and applied. Key facilitators included the guidelines’ strong evidence and multidisciplinary development. Reported barriers included limited availability or high cost of recommended interventions. Respondents suggested improvements related to the timing of updates, dissemination strategies, and the inclusion of patient-facing guidelines.  Conclusions: MASCC CPGs are widely recognized and valued globally, yet implementation remains variable. Targeted efforts to address resource constraints and enhance dissemination may strengthen their global awareness and implementation.  Supplementary information: The online version contains supplementary material available at https://doi.org/10.1007/s00520-026-11388-1.
SN  - 0941-4355
SN  - 1433-7339
ER  -