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Peer-reviewedCC BY-NCIranian journal of biotechnology

Filamin A Promotes Malignant Progression and Poor Prognosis in Glioma by Regulating EMT-Related Signaling Pathways.

  • Ye Yang1,2
  • Jiayuan Li1
  • Shunyao Zhang3
  • Jing Li2
  • Xuetao Han1
  • Liubing Hou1,4
  • Huandi Zhou1,4,5
  • Xiaoying Xue1,5
5 affiliations
  1. 1Department of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
  2. 2Department of Oncology, Shijiazhuang People's Hospital, Shijiazhuang, 050000, Hebei, China.
  3. 3Department of Neurosurgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
  4. 4Department of Central Laboratory, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, China.
  5. 5Hebei Key Laboratory of Etiology Tracing and Individualized Diagnosis and Treatment for Digestive System Carcinoma, The Second Hospital of Hebei Medical, University, Shijiazhuang, 050000, Hebei, China.
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Abstract

Background

Filamin A (FLNA), a scaffolding protein extensively expressed in various tumor cells, is involved in regulating multiple cellular functions.Objective

This study aimed to investigate the role of FLNA in the occurrence, development, and prognosis of glioma.Materials and methods

Firstly, data from public databases including The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and Gene Expression Omnibus (GEO) were utilized to analyze FLNA expression in glioma, evaluate the impact of differential FLNA expression on the prognosis of glioma patients, and validate the findings using tissue samples from our institution. Subsequently, cell experiments were conducted to confirm the effect of FLNA on the malignant phenotype of glioma cells. Finally, differential gene expression analysis and Gene Set Enrichment Analysis (GSEA) were performed to explore the association between FLNA and downstream signal transduction pathways.Results

In the TCGA, CGGA, and GEO databases, FLNA expression was significantly higher in tumor tissues than in normal tissues, with a notably higher expression in glioblastoma multiforme (GBM) compared to lower-grade glioma (LGG). Survival analysis revealed a negative correlation between FLNA expression and patient survival. Receiver Operating Characteristic (ROC) curve analysis indicated that FLNA could serve as a prognostic indicator for glioma. Univariate and multivariate analyses identified FLNA as a high-risk factor influencing prognosis. In clinical samples from our institution, FLNA expression was significantly elevated in glioma tissues relative to adjacent non-tumor tissues. In vitro experiments demonstrated that glioma cells with high FLNA expression exhibited enhanced proliferation, migration, and invasion capabilities. Gene enrichment analysis suggested a potential association between FLNA and the Epithelial-Mesenchymal Transition (EMT) process.Conclusion

FLNA is highly expressed in glioma and correlates with poor prognosis. It may enhance the proliferation, migration, and invasion of glioma cells through the EMT process, thereby emerging as a potential independent prognostic factor for glioma.

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Cite

BibTeXRIS
BibTeX
@article{yang2026filamin,
  title = {{Filamin A Promotes Malignant Progression and Poor Prognosis in Glioma by Regulating EMT-Related Signaling Pathways.}},
  author = {Ye Yang and Jiayuan Li and Shunyao Zhang and Jing Li and Xuetao Han and Liubing Hou and Huandi Zhou and Xiaoying Xue},
  journal = {Iranian journal of biotechnology},
  year = {2026},
  month = oct,
  doi = {10.30498/ijb.2026.572516.4360},
  url = {https://europepmc.org/article/MED/42928835},
  note = {CC BY-NC},
}
RIS
TY  - JOUR
TI  - Filamin A Promotes Malignant Progression and Poor Prognosis in Glioma by Regulating EMT-Related Signaling Pathways.
AU  - Ye Yang
AU  - Jiayuan Li
AU  - Shunyao Zhang
AU  - Jing Li
AU  - Xuetao Han
AU  - Liubing Hou
AU  - Huandi Zhou
AU  - Xiaoying Xue
PY  - 2026
DA  - 2026/10/01
JO  - Iranian journal of biotechnology
DO  - 10.30498/ijb.2026.572516.4360
UR  - https://europepmc.org/article/MED/42928835
AB  - Background  Filamin A (FLNA), a scaffolding protein extensively expressed in various tumor cells, is involved in regulating multiple cellular functions.Objective  This study aimed to investigate the role of FLNA in the occurrence, development, and prognosis of glioma.Materials and methods  Firstly, data from public databases including The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and Gene Expression Omnibus (GEO) were utilized to analyze FLNA expression in glioma, evaluate the impact of differential FLNA expression on the prognosis of glioma patients, and validate the findings using tissue samples from our institution. Subsequently, cell experiments were conducted to confirm the effect of FLNA on the malignant phenotype of glioma cells. Finally, differential gene expression analysis and Gene Set Enrichment Analysis (GSEA) were performed to explore the association between FLNA and downstream signal transduction pathways.Results  In the TCGA, CGGA, and GEO databases, FLNA expression was significantly higher in tumor tissues than in normal tissues, with a notably higher expression in glioblastoma multiforme (GBM) compared to lower-grade glioma (LGG). Survival analysis revealed a negative correlation between FLNA expression and patient survival. Receiver Operating Characteristic (ROC) curve analysis indicated that FLNA could serve as a prognostic indicator for glioma. Univariate and multivariate analyses identified FLNA as a high-risk factor influencing prognosis. In clinical samples from our institution, FLNA expression was significantly elevated in glioma tissues relative to adjacent non-tumor tissues. In vitro experiments demonstrated that glioma cells with high FLNA expression exhibited enhanced proliferation, migration, and invasion capabilities. Gene enrichment analysis suggested a potential association between FLNA and the Epithelial-Mesenchymal Transition (EMT) process.Conclusion  FLNA is highly expressed in glioma and correlates with poor prognosis. It may enhance the proliferation, migration, and invasion of glioma cells through the EMT process, thereby emerging as a potential independent prognostic factor for glioma.
SN  - 1728-3043
SN  - 2322-2921
ER  -