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PreprintCC BY-NC-NDChemRxiv

Supramolecular Eutectogels Based on Mangiferin, a Glucose-Appended Natural Herbal Compound

  • Fumiko Nakagawa1
  • Sayuri L. Higashi1,2,3
  • Shin-ichiro Kawano4
  • Masato Ikeda1,3,4,5,6
6 affiliations
  1. 1United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, 1-1 Yanagido, Gifu, Japan, 501-1193
  2. 2Institute for Advanced Study, Gifu University, 1-1 Yanagido, Gifu, Japan, 501-1193
  3. 3Center for One Medicine Innovative Translational Research (COMIT), Institute for Advanced Study, Gifu University, 1-1 Yanagido, Gifu, Japan, 501-1193
  4. 4Department of Life Science and Chemistry, Graduate School of Natural Science and Technology, Gifu University, 1-1 Yanagido, Gifu, Japan, 501-1193
  5. 5Institute for Glyco-core Research (iGCORE), Gifu University, 1-1 Yanagido, Gifu, Japan, 501-1193
  6. 6Innovation Research Center for Quantum Medicine, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, Japan, 501-1193
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Abstract

Deep eutectic solvents (DESs) have attracted considerable attention as sustainable, next-generation solvents. In this study, we report the formation of supramolecular eutectogels using mangiferin (MF), a naturally occurring C -glucosyl xanthone. MF successfully induced gelation in typical DESs composed of choline chloride and various hydrogen-bond donors, including urea, ethylene glycol, and glycerol. The gelation behavior was dependent on the hydrogen-bond donor, with significant differences observed in the time required for gelation. Furthermore, microscopic observations and XRD measurements revealed that MF formed distinct self-assembled network structures depending on the DES composition. Rheological measurements revealed the viscoelastic properties of the eutectogels, which supported the formation of three-dimensional supramolecular networks. These findings highlight the potential of MF as a bio-based gelator for DES-based soft materials and provide valuable insights into the rational design of sustainable supramolecular eutectogels for future applications.

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Cite

BibTeXRIS
BibTeX
@misc{nakagawa2026supramolecular,
  title = {{Supramolecular Eutectogels Based on Mangiferin, a Glucose-Appended Natural Herbal Compound}},
  author = {Fumiko Nakagawa and Sayuri L. Higashi and Shin-ichiro Kawano and Masato Ikeda},
  howpublished = {ChemRxiv},
  year = {2026},
  month = oct,
  doi = {10.26434/chemrxiv.15010534/v1},
  url = {https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010534/v1},
  note = {CC BY-NC-ND},
}
RIS
TY  - UNPB
TI  - Supramolecular Eutectogels Based on Mangiferin, a Glucose-Appended Natural Herbal Compound
AU  - Fumiko Nakagawa
AU  - Sayuri L. Higashi
AU  - Shin-ichiro Kawano
AU  - Masato Ikeda
PY  - 2026
DA  - 2026/10/15
PB  - ChemRxiv
DO  - 10.26434/chemrxiv.15010534/v1
UR  - https://chemrxiv.org/doi/full/10.26434/chemrxiv.15010534/v1
AB  - Deep eutectic solvents (DESs) have attracted considerable attention as sustainable, next-generation solvents. In this study, we report the formation of supramolecular eutectogels using mangiferin (MF), a naturally occurring C -glucosyl xanthone. MF successfully induced gelation in typical DESs composed of choline chloride and various hydrogen-bond donors, including urea, ethylene glycol, and glycerol. The gelation behavior was dependent on the hydrogen-bond donor, with significant differences observed in the time required for gelation. Furthermore, microscopic observations and XRD measurements revealed that MF formed distinct self-assembled network structures depending on the DES composition. Rheological measurements revealed the viscoelastic properties of the eutectogels, which supported the formation of three-dimensional supramolecular networks. These findings highlight the potential of MF as a bio-based gelator for DES-based soft materials and provide valuable insights into the rational design of sustainable supramolecular eutectogels for future applications.
ER  -