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Peer-reviewedCC BYFrontiers in physiology

Resistance training volume for major depressive disorder: the MoveMind randomized controlled trial protocol.

  • Giovanni Henrique Quizzini1,2
  • Jessenia Marise Sales Campos1,2
  • Thaís Aparecida Medeiros Amorim1,2
  • Marcelo Augusto Alves Dos Santos1,2
  • André Felipe Oliveira da Cruz1
  • Mateus Sanches Jokura1
  • Matheus Augusto Martins Correia1
  • Julia Elis Baraldo1
  • Marina Trombetta-Lima3
  • Camila Nascimento4
  • Andrea Deslandes5
  • André Oliveira Werneck6
6 more authors
  • Brendon Stubbs7,8,9,10,11,12
  • Hashim Islam13
  • Alberto Jiménez-Maldonado14
  • Felipe Barreto Schuch5,15,16,17,18
  • Lucas Melo Neves19
  • Fabrício Eduardo Rossi1,2
19 affiliations
  1. 1Immunometabolism of Skeletal Muscle and Exercise Research Group and Strength Training and Exercise Research Group (GEDEF), Department of Physical Education, São Paulo State University (UNESP), School of Technology and Science (FCT), Presidente Prudente, Brazil.
  2. 2Graduate Program in Movement Science - Interunits, São Paulo State University (UNESP), Presidente Prudente, Brazil.
  3. 3Department of Pharmaceutical Technology and Biopharmacy, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, Netherlands.
  4. 4Department of Biochemistry, Federal University of São Paulo, São Paulo, São Paulo, Brazil.
  5. 5Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
  6. 6Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States.
  7. 7Clinical Division of Social Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
  8. 8Comprehensive Center for Clinical Neurosciences and Mental Health (C3NMH), Medical University of Vienna, Vienna, Austria.
  9. 9Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, United Kingdom.
  10. 10Division of Psychology and Mental Health, Manchester Academic Health Science Centre, Manchester, United Kingdom.
  11. 11University of Manchester, Manchester, United Kingdom.
  12. 12Department of Psychiatry and Neurosciences, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  13. 13School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC, Canada.
  14. 14Facultad de Deportes, Universidad Autónoma de Baja California, Ensenada, Mexico.
  15. 15Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, VIC, Australia.
  16. 16Institute for Physical Activity and Nutrition (IPAN), Deakin University, Geelong, VIC, Australia.
  17. 17Graduate Program of Movement and Rehabilitation Sciences, Universidade Federal de Santa Maria, Santa Maria, Brazil.
  18. 18Faculty of Health Sciences, Universidad Autónoma de Chile, Santiago, Chile.
  19. 19Graduate Program Human Development and Technologies, São Paulo State University (UNESP), Rio Claro, Brazil.
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Abstract

This randomized controlled trial aims to investigate the effects of resistance training (RT) volume (high vs. low) and non-exercise group on depressive symptoms, remission rates, adherence and the psychological and neurobiological mechanisms underlying these effects in patients with major depressive disorder (MDD). A total of 150 adults (18-59 years) diagnosed with MDD will be randomized into three groups: high-volume RT (HV, n=50; 4 sets of 10-12 repetition maximum [RM]), low-volume RT (LV, n=50; 2 sets of 10-12 RM), and a non-exercise control group (CG, n=50). Participants in the intervention groups will train three non-consecutive days per week for 8 weeks. The primary outcome, depressive symptoms, will be assessed by a psychiatrist using the Montgomery-Åsberg Depression Rating Scale. Secondary outcomes will include potential psychological mechanisms (perceived self-efficacy, affective responses to exercise, and well-being), assessed at baseline, post-intervention, and at the 3-month follow-up, and neurobiological mechanisms assessed by inflammatory and metabolic biomarkers related to MDD pathophysiology, including TNF-α, IL-6, IL-10, IL-1β, CRP, IGF-1, BDNF, insulin, glucose, and cortisol, measured before and after the intervention. Tertiary outcomes will include dietary intake and ultra-processed food consumption (24-hour dietary recall), body composition (DXA), muscular strength, and sleep quality. Intervention efficacy will be analyzed using intention-to-treat linear mixed-effects models. The findings may contribute to more effective, personalized, and sustainable RT prescriptions that improve adherence and complement conventional treatments for MDD.Clinical trials registration

https://ensaiosclinicos.gov.br/rg/, identifier RBR-9tn4ncp.

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Cite

BibTeXRIS
BibTeX
@article{quizzini2026resistance,
  title = {{Resistance training volume for major depressive disorder: the MoveMind randomized controlled trial protocol.}},
  author = {Giovanni Henrique Quizzini and Jessenia Marise Sales Campos and Thaís Aparecida Medeiros Amorim and Marcelo Augusto Alves Dos Santos and André Felipe Oliveira da Cruz and Mateus Sanches Jokura and Matheus Augusto Martins Correia and Julia Elis Baraldo and Marina Trombetta-Lima and Camila Nascimento and Andrea Deslandes and André Oliveira Werneck and Brendon Stubbs and Hashim Islam and Alberto Jiménez-Maldonado and Felipe Barreto Schuch and Lucas Melo Neves and Fabrício Eduardo Rossi},
  journal = {Frontiers in physiology},
  year = {2026},
  month = oct,
  doi = {10.3389/fphys.2026.1943543},
  url = {https://europepmc.org/article/MED/42952510},
  note = {CC BY},
}
RIS
TY  - JOUR
TI  - Resistance training volume for major depressive disorder: the MoveMind randomized controlled trial protocol.
AU  - Giovanni Henrique Quizzini
AU  - Jessenia Marise Sales Campos
AU  - Thaís Aparecida Medeiros Amorim
AU  - Marcelo Augusto Alves Dos Santos
AU  - André Felipe Oliveira da Cruz
AU  - Mateus Sanches Jokura
AU  - Matheus Augusto Martins Correia
AU  - Julia Elis Baraldo
AU  - Marina Trombetta-Lima
AU  - Camila Nascimento
AU  - Andrea Deslandes
AU  - André Oliveira Werneck
AU  - Brendon Stubbs
AU  - Hashim Islam
AU  - Alberto Jiménez-Maldonado
AU  - Felipe Barreto Schuch
AU  - Lucas Melo Neves
AU  - Fabrício Eduardo Rossi
PY  - 2026
DA  - 2026/10/14
JO  - Frontiers in physiology
DO  - 10.3389/fphys.2026.1943543
UR  - https://europepmc.org/article/MED/42952510
AB  - This randomized controlled trial aims to investigate the effects of resistance training (RT) volume (high vs. low) and non-exercise group on depressive symptoms, remission rates, adherence and the psychological and neurobiological mechanisms underlying these effects in patients with major depressive disorder (MDD). A total of 150 adults (18-59 years) diagnosed with MDD will be randomized into three groups: high-volume RT (HV, n=50; 4 sets of 10-12 repetition maximum [RM]), low-volume RT (LV, n=50; 2 sets of 10-12 RM), and a non-exercise control group (CG, n=50). Participants in the intervention groups will train three non-consecutive days per week for 8 weeks. The primary outcome, depressive symptoms, will be assessed by a psychiatrist using the Montgomery-Åsberg Depression Rating Scale. Secondary outcomes will include potential psychological mechanisms (perceived self-efficacy, affective responses to exercise, and well-being), assessed at baseline, post-intervention, and at the 3-month follow-up, and neurobiological mechanisms assessed by inflammatory and metabolic biomarkers related to MDD pathophysiology, including TNF-α, IL-6, IL-10, IL-1β, CRP, IGF-1, BDNF, insulin, glucose, and cortisol, measured before and after the intervention. Tertiary outcomes will include dietary intake and ultra-processed food consumption (24-hour dietary recall), body composition (DXA), muscular strength, and sleep quality. Intervention efficacy will be analyzed using intention-to-treat linear mixed-effects models. The findings may contribute to more effective, personalized, and sustainable RT prescriptions that improve adherence and complement conventional treatments for MDD.Clinical trials registration  https://ensaiosclinicos.gov.br/rg/, identifier RBR-9tn4ncp.
SN  - 1664-042X
ER  -