Effects of High-Inorganic-Phosphorus Diet on Intestinal Mucosal Injury and Immune Alteration in Mice
- 1School of Life Sciences and Health , University of Health and Rehabilitation Sciences , Qingdao , 266113 , China
- 2School of Food Science and Engineering , Foshan University , Foshan , 528225 , China
Abstract
Background/Objectives: Excessive dietary inorganic phosphate (Pi) as a food additive poses potential health risks. Methods: This study investigated the impact of excessive dietary inorganic phosphate on intestinal and immune homeostasis in mice using gradient Pi exposure combined with an inflammatory model. Results: Pi overload induced atrophy in the thymus, spleen, and kidney; damaged the intestinal barrier; reduced the villus height-to-crypt-depth ratio; and decreased goblet cell numbers. Altered levels of serum sIgA and IgE, as well as intestinal IgA, IgG, IgE, and IgM, together with decreased IFN-α, indicated altered levels of immunoglobulins and cytokines under Pi treatment. Proteomic analysis revealed differential expression of key proteins, including CNTFR and Bcl2l1 in the JAK/STAT pathway and metabolic regulators CPT1α and IDH1, when comparing Pi-treated mice with the control group. Conclusions: These preliminary findings suggest that Pi may affect intestinal mucosal barrier function and systemic immune response through immune regulation and mitochondrial metabolic pathways, providing preliminary insight into the potential health implications of Pi overconsumption in humans.
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BibTeX
@article{sun2026effects,
title = {{Effects of High-Inorganic-Phosphorus Diet on Intestinal Mucosal Injury and Immune Alteration in Mice}},
author = {Zongchao Sun and Yuxin Zhao and Shiya Huang and Yunhan Luan and Yinuo Wang and R R Wang and Weiwei Wu and Danli Huang and Jiankang Liu and Yinghui Zhang},
journal = {Nutrients},
year = {2026},
month = may,
doi = {10.3390/nu18101590},
url = {https://doi.org/10.3390/nu18101590},
note = {CC BY},
}
RIS
TY - JOUR
TI - Effects of High-Inorganic-Phosphorus Diet on Intestinal Mucosal Injury and Immune Alteration in Mice
AU - Zongchao Sun
AU - Yuxin Zhao
AU - Shiya Huang
AU - Yunhan Luan
AU - Yinuo Wang
AU - R R Wang
AU - Weiwei Wu
AU - Danli Huang
AU - Jiankang Liu
AU - Yinghui Zhang
PY - 2026
DA - 2026/05/16
JO - Nutrients
DO - 10.3390/nu18101590
UR - https://doi.org/10.3390/nu18101590
AB - Background/Objectives: Excessive dietary inorganic phosphate (Pi) as a food additive poses potential health risks. Methods: This study investigated the impact of excessive dietary inorganic phosphate on intestinal and immune homeostasis in mice using gradient Pi exposure combined with an inflammatory model. Results: Pi overload induced atrophy in the thymus, spleen, and kidney; damaged the intestinal barrier; reduced the villus height-to-crypt-depth ratio; and decreased goblet cell numbers. Altered levels of serum sIgA and IgE, as well as intestinal IgA, IgG, IgE, and IgM, together with decreased IFN-α, indicated altered levels of immunoglobulins and cytokines under Pi treatment. Proteomic analysis revealed differential expression of key proteins, including CNTFR and Bcl2l1 in the JAK/STAT pathway and metabolic regulators CPT1α and IDH1, when comparing Pi-treated mice with the control group. Conclusions: These preliminary findings suggest that Pi may affect intestinal mucosal barrier function and systemic immune response through immune regulation and mitochondrial metabolic pathways, providing preliminary insight into the potential health implications of Pi overconsumption in humans.
SN - 2072-6643
ER -