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Peer-reviewedCC BY-NC-NDReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology

Undifferentiated pleomorphic sarcoma expressing human chorionic gonadotropin beta subunit.

  • Michał Piekarz1
  • Anna Szczerba2
  • Aleksandra Śliwa2
  • Wiktoria Urban2
  • Anna Jankowska2
  • Jakub Żurawski3
  • Jerzy Nazar4
4 affiliations
  1. 1Department of Orthopedics and Traumatology of Locomotor System, Hospital in Puszczykowo, Puszczykowo, Poland.
  2. 2Department of Cell Biology, Poznan University of Medical Sciences, Poznan, Poland.
  3. 3Department of Immunobiology, Poznan University of Medical Sciences, Poznan, Poland.
  4. 4Department of Orthopedics, Traumatology and Hand Surgery, The Medical University of Bialystok Clinical Hospital, Bialystok, Poland.
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Abstract

Undifferentiated pleomorphic sarcoma (UPS) is a high-grade, aggressive malignant tumour of fibrogenic origin, characterised by substantial cellular heterogeneity and poor prognosis. The lack of specific early clinical manifestations delays diagnosis and effective therapeutic intervention. In this study, we present a case of human chorionic gonadotropin beta subunit (hCGβ) expression in UPS. The presence of hCGβ was confirmed at both the mRNA and protein levels using quantitative polymerase chain reaction (qPCR), and immunohistochemistry, respectively. Transcripts encoding hCGβ were also detected in circulating tumour cells (CTCs) isolated from the patient's blood. These findings highlight hCGβ as a potential molecular marker associated with UPS biology and its tumour microenvironment. The identification of hCGβ-expressing CTCs through non-invasive liquid biopsy underscores the potential of this marker for real-time monitoring of tumour progression and for tailoring personalised therapeutic strategies. The results of the study support the growing concept that integrating molecular markers derived from the tumour microenvironment into diagnostic and therapeutic frameworks may significantly enhance precision oncology approaches for soft tissue sarcomas.

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Cite

BibTeXRIS
BibTeX
@article{piekarz2026undifferentiated,
  title = {{Undifferentiated pleomorphic sarcoma expressing human chorionic gonadotropin beta subunit.}},
  author = {Michał Piekarz and Anna Szczerba and Aleksandra Śliwa and Wiktoria Urban and Anna Jankowska and Jakub Żurawski and Jerzy Nazar},
  journal = {Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology},
  year = {2026},
  month = nov,
  doi = {10.5603/rpor.111761},
  url = {https://europepmc.org/article/MED/42997853},
  note = {CC BY-NC-ND},
}
RIS
TY  - JOUR
TI  - Undifferentiated pleomorphic sarcoma expressing human chorionic gonadotropin beta subunit.
AU  - Michał Piekarz
AU  - Anna Szczerba
AU  - Aleksandra Śliwa
AU  - Wiktoria Urban
AU  - Anna Jankowska
AU  - Jakub Żurawski
AU  - Jerzy Nazar
PY  - 2026
DA  - 2026/11/01
JO  - Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
DO  - 10.5603/rpor.111761
UR  - https://europepmc.org/article/MED/42997853
AB  - Undifferentiated pleomorphic sarcoma (UPS) is a high-grade, aggressive malignant tumour of fibrogenic origin, characterised by substantial cellular heterogeneity and poor prognosis. The lack of specific early clinical manifestations delays diagnosis and effective therapeutic intervention. In this study, we present a case of human chorionic gonadotropin beta subunit (hCGβ) expression in UPS. The presence of hCGβ was confirmed at both the mRNA and protein levels using quantitative polymerase chain reaction (qPCR), and immunohistochemistry, respectively. Transcripts encoding hCGβ were also detected in circulating tumour cells (CTCs) isolated from the patient's blood. These findings highlight hCGβ as a potential molecular marker associated with UPS biology and its tumour microenvironment. The identification of hCGβ-expressing CTCs through non-invasive liquid biopsy underscores the potential of this marker for real-time monitoring of tumour progression and for tailoring personalised therapeutic strategies. The results of the study support the growing concept that integrating molecular markers derived from the tumour microenvironment into diagnostic and therapeutic frameworks may significantly enhance precision oncology approaches for soft tissue sarcomas.
SN  - 1507-1367
SN  - 2083-4640
ER  -