Peer-reviewedCC BY-NC-NDCirculation Journal
Comparison of Atheroma Burden Changes Using Conventional vs. End-Diastolic Intravascular Ultrasound Segmentation ― Post Hoc Analysis of the PACMAN-AMI Study ―
Abstract
BACKGROUND: This study compared changes in percentage atheroma volume (PAV) using an end-diastolic (ED) intravascular ultrasound (IVUS) segmentation approach vs. the conventional 1-mm interval analysis in serial IVUS data from the PACMAN-AMI trial. METHODS AND RESULTS: , respectively [P=0.823]; PAV: 1.29% vs. 1.25%, respectively [P=0.911]). Biomarker correlations with TAV and PAV changes did not differ between approaches. CONCLUSIONS: ED- and 1-mm-based analyses demonstrated comparable treatment effects of alirocumab on plaque regression in PACMAN-AMI. These findings support the use of the less time-consuming 1-mm segmentation method in serial IVUS studies.
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BibTeX
@article{yap2026comparison,
title = {{Comparison of Atheroma Burden Changes Using Conventional vs. End-Diastolic Intravascular Ultrasound Segmentation ― Post Hoc Analysis of the PACMAN-AMI Study ―}},
author = {Nathan Angelo Lecaros Yap and Christos V. Bourantas and Sylvain Losdat and Nathaniel Yu Jian Ng and Jonas Häner and Ibrahim Halil Tanboga and Tatsuhiko Otsuka and Yasushi Ueki and Andreas Baumbach and Anthony Mathur and Ryota Kakizaki and Ernest Spitzer and Jouke Dijkstra and Thomas Engstrøm and David Spirk and Irene Lang and Konstantinos C. Koskinas and Lorenz Räber},
journal = {Circulation Journal},
year = {2026},
month = jul,
doi = {10.1253/circj.cj-25-0590},
url = {https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-25-0590/_article},
note = {CC BY-NC-ND},
}
RIS
TY - JOUR
TI - Comparison of Atheroma Burden Changes Using Conventional vs. End-Diastolic Intravascular Ultrasound Segmentation ― Post Hoc Analysis of the PACMAN-AMI Study ―
AU - Nathan Angelo Lecaros Yap
AU - Christos V. Bourantas
AU - Sylvain Losdat
AU - Nathaniel Yu Jian Ng
AU - Jonas Häner
AU - Ibrahim Halil Tanboga
AU - Tatsuhiko Otsuka
AU - Yasushi Ueki
AU - Andreas Baumbach
AU - Anthony Mathur
AU - Ryota Kakizaki
AU - Ernest Spitzer
AU - Jouke Dijkstra
AU - Thomas Engstrøm
AU - David Spirk
AU - Irene Lang
AU - Konstantinos C. Koskinas
AU - Lorenz Räber
PY - 2026
DA - 2026/07/24
JO - Circulation Journal
DO - 10.1253/circj.cj-25-0590
UR - https://www.jstage.jst.go.jp/article/circj/90/8/90_CJ-25-0590/_article
AB - BACKGROUND: This study compared changes in percentage atheroma volume (PAV) using an end-diastolic (ED) intravascular ultrasound (IVUS) segmentation approach vs. the conventional 1-mm interval analysis in serial IVUS data from the PACMAN-AMI trial. METHODS AND RESULTS: , respectively [P=0.823]; PAV: 1.29% vs. 1.25%, respectively [P=0.911]). Biomarker correlations with TAV and PAV changes did not differ between approaches. CONCLUSIONS: ED- and 1-mm-based analyses demonstrated comparable treatment effects of alirocumab on plaque regression in PACMAN-AMI. These findings support the use of the less time-consuming 1-mm segmentation method in serial IVUS studies.
SN - 1347-4820
SN - 1346-9843
ER -