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Peer-reviewedCC BY 4.0Nature Communications

Unifying non-Markovian Dynamics and Agent Heterogeneity in Scalable Stochastic Networks

Abstract

Stochastic processes underpin dynamics across biology, physics, epidemiology, and finance, yet accurately simulating them remains a major challenge. Classical approaches such as the Gillespie algorithm are exact for Markovian, time-independent systems, where propensities depend only on the current state and agents of a given type are statistically identical. While efficient, this framework misses a defining feature of many real systems: heterogeneity and memory at the level of individual agents. Cells may divide or differentiate on distinct intrinsic timescales, individuals may preferentially interact with specific partners, and inter-event-time distributions can deviate strongly from the exponential. We introduce MOSAIC (Modeling of Stochastic Agents with Individual Complexity), a general and scalable framework that embeds agent-specific properties directly into the dynamics. MOSAIC unifies heterogeneous rates, dynamic interaction preferences, and both Markovian and non-Markovian waiting-time distributions within a single stochastic formalism, while retaining Gillespie-like computational cost.

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BibTeX
@article{pelissier2026unifying,
  title = {{Unifying non-Markovian Dynamics and Agent Heterogeneity in Scalable Stochastic Networks}},
  author = {Aurelien Pelissier and Miroslav Phan and Didier Le Bail and Niko Beerenwinkel and Maria Rodriguez Martinez},
  journal = {Nature Communications},
  year = {2026},
  month = sep,
  doi = {10.1038/s41467-026-69817-y},
  eprint = {2609.31125},
  archivePrefix = {arXiv},
  url = {https://hal.science/hal-05763067v1},
  note = {CC BY 4.0},
}
RIS
TY  - JOUR
TI  - Unifying non-Markovian Dynamics and Agent Heterogeneity in Scalable Stochastic Networks
AU  - Aurelien Pelissier
AU  - Miroslav Phan
AU  - Didier Le Bail
AU  - Niko Beerenwinkel
AU  - Maria Rodriguez Martinez
PY  - 2026
DA  - 2026/09/24
JO  - Nature Communications
DO  - 10.1038/s41467-026-69817-y
UR  - https://hal.science/hal-05763067v1
AB  - Stochastic processes underpin dynamics across biology, physics, epidemiology, and finance, yet accurately simulating them remains a major challenge. Classical approaches such as the Gillespie algorithm are exact for Markovian, time-independent systems, where propensities depend only on the current state and agents of a given type are statistically identical. While efficient, this framework misses a defining feature of many real systems: heterogeneity and memory at the level of individual agents. Cells may divide or differentiate on distinct intrinsic timescales, individuals may preferentially interact with specific partners, and inter-event-time distributions can deviate strongly from the exponential. We introduce MOSAIC (Modeling of Stochastic Agents with Individual Complexity), a general and scalable framework that embeds agent-specific properties directly into the dynamics. MOSAIC unifies heterogeneous rates, dynamic interaction preferences, and both Markovian and non-Markovian waiting-time distributions within a single stochastic formalism, while retaining Gillespie-like computational cost.
SN  - 2041-1723
SN  - 2041-1723
ER  -