Human biomarker navigator
17 affiliations
- 1Innovation Institute of Integrated Traditional Chinese and Western Medicine, Shandong First Medical University & Shandong Academy of Medical Sciences Jinan China
- 2Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China
- 3College of Pharmacy, Inner Mongolia Medical University Hohhot China
- 4Department of Urology Jiangsu Key Laboratory of Urological Disease Prevention and Treatment, The Second Affiliated Hospital of Nanjing Medical University, Nanjing Medical University Nanjing China
- 5School of Life Sciences, Yangtze University Jingzhou China
- 6School of Life Sciences and Medicine, Shandong University of Technology Zibo China
- 7Department of Diet and Nutritional Sciences Ibadat International University Islamabad Pakistan
- 8Department of Thoracic Surgery the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center, Nanjing Medical University Wuxi China
- 9College of Science, National University of Defense Technology Changsha China
- 10Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo and Biosensing, College of Biology, Hunan University Changsha China
- 11The Pq Laboratory of BiomeDx/Rx, Department of Biomedical Engineering Binghamton University Binghamton New York USA
- 12Department of Biology Science Faculty, Selcuk University Konya Turkey
- 13College of Chemistry and Molecular Sciences, Wuhan University Wuhan China
- 14National Institute of TCM Constitution and Preventive Medicine, Beijing University of Chinese Medicine Beijing China
- 15State Key Laboratory of Chinese Medicine Modernization, College of Pharmaceutical Sciences, Zhejiang University Hangzhou China
- 16School of Pharmaceutical Sciences, Zhejiang Chinese Medical University Hangzhou China
- 17Department of Laboratory Medicine Chongqing Center for Clinical Laboratory, Chongqing Academy of Medical Sciences, Chongqing General Hospital, School of Medicine, Chongqing University Chongqing China
Abstract
Biomarkers play a pivotal role in contemporary medical research, particularly in the early diagnosis of diseases and personalized treatment. Although previous studies have systematically reviewed markers across various disease domains, an integrated framework that connects major physiological systems, encompasses multiple organs, and spans a broad spectrum of diseases is still lacking. In the context of modern health challenges, marked by the high prevalence of chronic diseases and widespread comorbidities, establishing a panoramic biomarker navigation system is imperative. This review offers the initial comprehensive elucidation of the biomarker interaction networks across diverse systems, organs, and diseases, and delineates the operational framework for establishing a “biomarker navigation system”. The core contribution of this work is a transition from ‘knowledge enumeration’ to a more integrated, systems‐level approach. This provides new perspectives in systems biology for understanding the shared pathological foundations of comorbidities. Furthermore, it provides a theoretical basis for a reorientation in medicine, from a focus on ‘treating existing diseases’ to ‘preventive interventions’ and from ‘single‐disease management’ to a comprehensive, systems‐based approach. To facilitate the exploration and application of this system–organ–disease–biomarker network, we developed the “Human Biomarker Navigator” web platform (http://www.hbiomarker.com), which allows researchers and clinicians to efficiently retrieve the functional characteristics and clinical significance of diverse biomarkers across different disease contexts.
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BibTeX
@article{li2026human,
title = {{Human biomarker navigator}},
author = {Meng‐Yao Li and Qian Zhang and Zijie Wang and Zeping Gui and Jing Liu and Jingda Li and Maojun Jiang and Zukang Chang and Qingqing Han and Bendong Yang and Tariq Saeed and Jun Li and Jinghan Jia and Chenghu Song and Tong Shao and Tianhuan Peng and Xueying Zhang and Pingping Guo and Jun Luo and Gangao Yang and Yuan Wan and Gokhan Zengin and Quan Yuan and Lingru Li and Xiaohui Fan and Yang Luo and Lvyun Zhu and Yanfei Zheng and Wenjun Mao and Wenlong Sun},
journal = {iMeta},
year = {2026},
month = aug,
doi = {10.1002/imt2.70157},
url = {https://doi.org/10.1002/imt2.70157},
note = {CC BY 4.0},
}
RIS
TY - JOUR
TI - Human biomarker navigator
AU - Meng‐Yao Li
AU - Qian Zhang
AU - Zijie Wang
AU - Zeping Gui
AU - Jing Liu
AU - Jingda Li
AU - Maojun Jiang
AU - Zukang Chang
AU - Qingqing Han
AU - Bendong Yang
AU - Tariq Saeed
AU - Jun Li
AU - Jinghan Jia
AU - Chenghu Song
AU - Tong Shao
AU - Tianhuan Peng
AU - Xueying Zhang
AU - Pingping Guo
AU - Jun Luo
AU - Gangao Yang
AU - Yuan Wan
AU - Gokhan Zengin
AU - Quan Yuan
AU - Lingru Li
AU - Xiaohui Fan
AU - Yang Luo
AU - Lvyun Zhu
AU - Yanfei Zheng
AU - Wenjun Mao
AU - Wenlong Sun
PY - 2026
DA - 2026/08/20
JO - iMeta
DO - 10.1002/imt2.70157
UR - https://doi.org/10.1002/imt2.70157
AB - Biomarkers play a pivotal role in contemporary medical research, particularly in the early diagnosis of diseases and personalized treatment. Although previous studies have systematically reviewed markers across various disease domains, an integrated framework that connects major physiological systems, encompasses multiple organs, and spans a broad spectrum of diseases is still lacking. In the context of modern health challenges, marked by the high prevalence of chronic diseases and widespread comorbidities, establishing a panoramic biomarker navigation system is imperative. This review offers the initial comprehensive elucidation of the biomarker interaction networks across diverse systems, organs, and diseases, and delineates the operational framework for establishing a “biomarker navigation system”. The core contribution of this work is a transition from ‘knowledge enumeration’ to a more integrated, systems‐level approach. This provides new perspectives in systems biology for understanding the shared pathological foundations of comorbidities. Furthermore, it provides a theoretical basis for a reorientation in medicine, from a focus on ‘treating existing diseases’ to ‘preventive interventions’ and from ‘single‐disease management’ to a comprehensive, systems‐based approach. To facilitate the exploration and application of this system–organ–disease–biomarker network, we developed the “Human Biomarker Navigator” web platform (http://www.hbiomarker.com), which allows researchers and clinicians to efficiently retrieve the functional characteristics and clinical significance of diverse biomarkers across different disease contexts.
SN - 2770-5986
SN - 2770-596X
ER -