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PreprintAll rights reservedbioRxiv

Sphingolipid-Driven Lipotoxicity Promotes Calcific Aortic Valve Disease Through ER-Stress-NF-κB-EndMT Signaling and Is Therapeutically Targetable Through Serine Palmitoyltransferase Inhibition

  • E. Rawish1
  • T. Rusack
  • P. R. Letsch
  • J. Inderhees
  • K. Haendler
  • C. Gragoll
  • J. C. Voran
  • M. Schneider
  • K. Kurz
  • M. R. Hosen
  • M. Behrensen
  • S. Denker
17 more authors
  • A. Kuenstner
  • T. Sauer
  • J. Duque-Escobar
  • T. Schmidt
  • D. Frank
  • T. Stiermaier
  • W. Raasch
  • O. J. Mueller
  • T. Zeller
  • H. S. Busch
  • T. Gemoll
  • C. Knosalla
  • M. Spielmann
  • Z. Aherrharou
  • S. A. Summers
  • I. Eitel
  • C. Frerker
  1. 1University Hospital Schleswig-Holstein, Medical Clinic II, Luebeck, Germany; DZHK (German Centre for Cardiovascular Research), partner site North, Luebeck, Germ
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BibTeX
@misc{rawish2026sphingolipiddriven,
  title = {{Sphingolipid-Driven Lipotoxicity Promotes Calcific Aortic Valve Disease Through ER-Stress-NF-κB-EndMT Signaling and Is Therapeutically Targetable Through Serine Palmitoyltransferase Inhibition}},
  author = {E. Rawish and T. Rusack and P. R. Letsch and J. Inderhees and K. Haendler and C. Gragoll and J. C. Voran and M. Schneider and K. Kurz and M. R. Hosen and M. Behrensen and S. Denker and A. Kuenstner and T. Sauer and J. Duque-Escobar and T. Schmidt and D. Frank and T. Stiermaier and W. Raasch and O. J. Mueller and T. Zeller and H. S. Busch and T. Gemoll and C. Knosalla and M. Spielmann and Z. Aherrharou and S. A. Summers and I. Eitel and C. Frerker},
  howpublished = {bioRxiv},
  year = {2026},
  month = oct,
  doi = {10.64898/2026.10.07.757226},
  url = {https://www.biorxiv.org/content/10.64898/2026.10.07.757226v1},
}
RIS
TY  - UNPB
TI  - Sphingolipid-Driven Lipotoxicity Promotes Calcific Aortic Valve Disease Through ER-Stress-NF-κB-EndMT Signaling and Is Therapeutically Targetable Through Serine Palmitoyltransferase Inhibition
AU  - E. Rawish
AU  - T. Rusack
AU  - P. R. Letsch
AU  - J. Inderhees
AU  - K. Haendler
AU  - C. Gragoll
AU  - J. C. Voran
AU  - M. Schneider
AU  - K. Kurz
AU  - M. R. Hosen
AU  - M. Behrensen
AU  - S. Denker
AU  - A. Kuenstner
AU  - T. Sauer
AU  - J. Duque-Escobar
AU  - T. Schmidt
AU  - D. Frank
AU  - T. Stiermaier
AU  - W. Raasch
AU  - O. J. Mueller
AU  - T. Zeller
AU  - H. S. Busch
AU  - T. Gemoll
AU  - C. Knosalla
AU  - M. Spielmann
AU  - Z. Aherrharou
AU  - S. A. Summers
AU  - I. Eitel
AU  - C. Frerker
PY  - 2026
DA  - 2026/10/07
PB  - bioRxiv
DO  - 10.64898/2026.10.07.757226
UR  - https://www.biorxiv.org/content/10.64898/2026.10.07.757226v1
ER  -