Peer-reviewedCC BYJournal for ImmunoTherapy of Cancer
811 AR166, a novel tri-specific immunocytokine, overcomes anti-PD-1 resistance by delivering cis-acting IL-2v via dual PD-1 and LAG-3 targeting
7 affiliations
- 1Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea (the Republic of)
- 22Y-Biologics Inc., Daejeon, Republic of Korea
- 3Y-Biologics, Inc., Daejeon, Republic of Korea
- 45Medpacto, Inc., Seoul, Korea, Republic of Korea
- 5Y-Biologics Inc., Daejeon, Republic of Korea
- 63ABION Inc., Seoul, Gwanak-gu, Republic of Korea
- 7Samsung Medical Center, Seoul, Republic of Korea
Related
- CBX3 Deletion Overcomes Ferroptosis Resistance in Colorectal Cancer by Targeting IFNγ/SLC7A11/SLC3A2 Axis
- Targeting SLC1A5-mediated glutamine metabolism overcomes PARP inhibitor resistance in ovarian cancer.
- Fingolimod overcomes cisplatin resistance in esophageal squamous cell carcinoma by targeting NUP54 to disrupt homologous recombination repair.
- Targeting oxidative phosphorylation with lixumistat overcomes PARP inhibitor resistance in ovarian cancer
- Fc-Dependent Targeting of the GAS6-MERTK Axis With Monoclonal and Bispecific Antibodies Overcomes Drug Resistance Across EGFR Mutations in Exons 19, 20, and 21.
BibTeX
@article{park2026ar166,
title = {{811 AR166, a novel tri-specific immunocytokine, overcomes anti-PD-1 resistance by delivering cis-acting IL-2v via dual PD-1 and LAG-3 targeting}},
author = {Su-Hyung Park and Wooick Jang and Jinkeol Mok and Juhan Yoon and Jaehyeon Kim and Jaeho Song and Jae-Seok Lee and Saehyung Lee and Seon-Mi Yu and Jihye Yoon and Wanki Park and Jung Ho Yoon and Young Woo Park and Seo-Young Koo and Min-Young Park and Seoyun Yang and Hye Kyung Hong and Yong Beom Cho},
journal = {Journal for ImmunoTherapy of Cancer},
year = {2026},
month = nov,
doi = {10.1136/jitc-2026-sitc2026.0811},
url = {https://doi.org/10.1136/jitc-2026-sitc2026.0811},
note = {CC BY},
}
RIS
TY - JOUR
TI - 811 AR166, a novel tri-specific immunocytokine, overcomes anti-PD-1 resistance by delivering cis-acting IL-2v via dual PD-1 and LAG-3 targeting
AU - Su-Hyung Park
AU - Wooick Jang
AU - Jinkeol Mok
AU - Juhan Yoon
AU - Jaehyeon Kim
AU - Jaeho Song
AU - Jae-Seok Lee
AU - Saehyung Lee
AU - Seon-Mi Yu
AU - Jihye Yoon
AU - Wanki Park
AU - Jung Ho Yoon
AU - Young Woo Park
AU - Seo-Young Koo
AU - Min-Young Park
AU - Seoyun Yang
AU - Hye Kyung Hong
AU - Yong Beom Cho
PY - 2026
DA - 2026/11/07
JO - Journal for ImmunoTherapy of Cancer
DO - 10.1136/jitc-2026-sitc2026.0811
UR - https://doi.org/10.1136/jitc-2026-sitc2026.0811
SN - 2051-1426
ER -